Dr Jonathan Mullins
Associate Professor
Biomedical Sciences
Telephone: (01792) 513569
Room: Academic Office - 135
First Floor
Institute of Life Science 1
Singleton Campus

Publications

  1. Chen, S., Austin-Muttitt, K., Zhang, L., Mullins, J., Lau, A. In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues Journal of Pharmacology and Experimental Therapeutics 371 1 75 86
  2. Gardner, J., Cushion, T., Niotakis, G., Olson, H., Grant, P., Scott, R., Stoodley, N., Cohen, J., Naidu, S., Attie-Bitach, T., Bonnières, M., Boutaud, L., Encha-Razavi, F., Palmer-Smith, S., Mugalaasi, H., Mullins, J., Pilz, D., Fry, A. Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation Brain Sciences 8 8 145
  3. Mair, W., Deng, W., Mullins, J., West, S., Wang, P., Besharat, N., Ellwood, S., Oliver, R., Lopez-Ruiz, F., Mullins, J. Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51 Frontiers in Microbiology 7
  4. McGirr, A., Lipina, T., Mun, H., Georgiou, J., Al-Amri, A., Ng, E., Zhai, D., Elliott, C., Cameron, R., Mullins, J., Liu, F., Baillie, G., Clapcote, S., Roder, J., Mullins, J. Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition Neuropsychopharmacology 41 4 1080 1092
  5. Chung, S., Bode, A., Cushion, T., Thomas, R., Hunt, C., Wood, S., Pickrell, W., Drew, C., Yamashita, S., Shiang, R., Leiz, S., Longhardt, A., Raile, V., Weschke, B., Puri, R., Verma, I., Harvey, R., Ratnasinghe, D., Parker, M., Rittey, C., Masri, A., Lingappa, L., Howell, O., Vanbellinghen, J., Mullins, J., Lynch, J., Rees, M., Mullins, J. GLRB is the third major gene of effect in hyperekplexia Human Molecular Genetics 22 5 927 940

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Teaching

  • PM-239F Doctor as Scholar and Scientist 1

    This module provides medical students with the foundation of scientific knowledge, which is required for the practice of medicine. Focusing on the principle of the Doctor as Scientist and Scholar (Tomorrow's Doctors, GMC 2009), this module enables students to develop their scientific knowledge within a clinical context.

  • PM-257 Neuroscience

    In order to help students understand the biological basis for behavioural neuroscience and neurological disorders, this module seeks to integrate the multidisciplinary sciences - for example, anatomy, physiology and biochemistry - that have combined to build the emerging field of neuroscience. The aim is to gain a mechanistic and holistic knowledge of the nervous system that builds from the molecular, cellular and developmental, to the systems level. In addition to exploring normal function, this module will introduce common disorders of the central and peripheral nervous systems in an integrated way. Students will be guided in exploring the scientific evidence around what is known and unknown and will be introduced to current research findings in the scientific literature.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-344C Prosiect Capfaen

    Nod y modiwl hwn yw rhoi cyfle i fyfyrwyr gael profiad dysgu capfaen drwy gymryd rhan yn eu prosiect eu hunain yn seiliedig ar gwestiwn ymchwil. Gan ddibynnu ar linyn cyflogadwyedd y myfyriwr yn y rhaglen, gall y prosiect fod yn seiliedig ar waith labordy, data neu addysg, ond bydd bob amser yn cynnwys cwestiwn ymchwil sy'n deillio o'r llenyddiaeth, ac sy'n canolbwyntio ar bwnc perthnasol i wyddor feddygol. Bydd yn gofyn cwestiwn ymchwil newydd ac yn cynnwys dadansoddiad beirniadol o ganfyddiadau ymchwil. Bydd myfyrwyr yn mireinio eu sgiliau cyfathrebu llafar ac ysgrifenedig i lefel raddedig, drwy lunio cyflwyniad rhagarweiniol ar gefndir y prosiect, ynghyd â thraethawd estynedig a chyflwyniad llafar ar ganfyddiadau eu hymchwil.

  • PM-345 Bioinformatics: From sequence to Function

    The ever increasing availability of genome sequences and protein structure data demands that molecular biologists are proficient at performing extensive data analyses to guide and support traditional laboratory-based research. This Module will provide the theoretical basis and practical training on computational tools currently used to assemble and interrogate genome sequences, infer gene and protein functions, and to examine protein structure data.

  • PM-349D Doctor as Scholar and Scientist 2

    This module further develops the student's scientific knowledge, building on the foundations laid in Year 1. Focusing on the principle of the Doctor as Scientist and Scholar (Tomorrow's Doctors, GMC 2009), this module enables students to enhance their scientific knowledge and understanding of its importance to clinical practice within a clinical context.

  • PM-358I Doctor as Scholar and Scientist 3

    This module enables medical students to integrate their scientific knowledge and clinical skills in order to apply it within the context of clinical practice, thus enhancing their ability to practice medicine. This module builds on the knowledge learned in the previous years, focusing on the notion of the Doctor as a Scientist and Scholar (Tomorrow's Doctors, GMC 2009).

  • PM-367C Doctor as Scholar and Scientist 4

    This module enables medical students to consolidate their scientific knowledge within the context of clinical practice, and prepares them for the Foundation Year training programme. This module builds on the knowledge learned in the previous years, focusing on the notion of the Doctor as Scientist and Scholar (Tomorrow's Doctors, GMC 2009).

Supervision

  • Using in silico methods to predict in vitro results at every scale from chemical mechanisms to primary screens (current)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • Development and application of a novel mass spectrometry ionisation source for biological chemistry (current)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Steven Kelly
  • Inhibiting IL-17 Production by Blocking Endogenous RORγt Agonists for the Treatment of Autoimmune Diseases (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof William Griffiths
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Yuqin Wang
  • Data mining patterns of receptor-drug interactions across vast biological and chemical space (current)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • Natural language processing (NLP) for clinical information extraction and healthcare research. (current)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Julian Halcox
  • Analysis of potential mRNA splice-affecting gene-variants identified in epilepsy families and cases (awarded 2019)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Mark Rees
    Other supervisor: Dr Seo-Kyung Chung
  • An In Silico Platform for the Drug Screening of Human CYP2D6 Variants (awarded 2019)

    Student name:
    PhD
    Other supervisor: Prof Paul Lewis
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins
  • Development of a comprehensive 3D structural database of human proteomic variation and pan-proteomic interaction with the most widely prescribed drugs. (awarded 2019)

    Student name:
    PhD
    Other supervisor: Dr Heledd Iago
    Other supervisor: Dr Jonathan Mullins