Associate Professor
Biomedical Sciences
Telephone: (01792) 295158
Email: JavaScript is required to view this email address.
Room: Academic Office - 428
Fourth Floor
Institute of Life Science 1
Singleton Campus

George is a steering member of the International Life Science Institute (ILSI) Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC) and co-chair of the quantitative and mode of action subgroups. The ILSI-HESI provides an international forum to advance the understanding of scientific issues related to human health, toxicology, risk assessment, and the environment.

George has been invited to give oral presentations and chair sessions at most of the major international Toxicology conferences in recent years. The IWGT was a particular highlight, and the resulting consensus statements have been published in a series of manuscripts that provide expert advice, these manuscripts have a history of influencing ICH, OECD and other regulatory policy revisions, and will thus be of international impact.

George has been lead academic on numerous international collaborations. These include US-FDA-NCTR, Health Canada, RIVM-Netherlands, AstraZeneca, Drugs for Neglected Disease Initiative (DNDi), Food Standards Agency, GlaxoSmithKline, Gentronix, Hoffman-La-Roche, Litron, and more. He also continues to co-lead the DNA damage group (in vitro Toxicology group) in the Institute of Life Science, as well as teaching on the Genetics Degree programme, and having a role as Director of Employability and Entrepreneurship for the Medical School.

George was awarded the prestigious UKEMS Young Scientist Award in 2012, in 2013 he became a Fellow of the Higher Education Academy, and in 2014 he became a British & European Registered Toxicologist and also won the very prestigious EEM(G)S Young Scientist Award.

In June 2017 George was voted in as President-Elect for the EEMGS society, and will become President in 2019. 

George has recently become a consultant, with clients including the pharmaceutical, food additive and chemical industries. A major aspect of many of these projects has been the derivation of point of departure metrics for use in human health risk assessments. Please contact him for further information on his services, which he runs through Swansea Innovations

Areas of Expertise

  • Genetic Toxicology
  • Mutation Testing
  • DNA Repair
  • Risk Assessment
  • Point of Departure
  • Dose Response Modelling


  1. Heflich, R., Johnson, G., Zeller, A., Marchetti, F., Douglas, G., Witt, K., Gollapudi, B., White, P. Mutation as a Toxicological Endpoint for Regulatory Decision‐Making Environmental and Molecular Mutagenesis
  2. Dertinger, S., Kraynak, A., Wheeldon, R., Bernacki, D., Bryce, S., Hall, N., Bemis, J., Galloway, S., Escobar, P., Johnson, G. Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy Environmental and Molecular Mutagenesis
  3. Kirkland, D., Levy, D., LeBaron, M., Aardema, M., Beevers, C., Bhalli, J., Douglas, G., Escobar, P., Farabaugh, C., Guerard, M., Johnson, G., Kulkarni, R., Le Curieux, F., Long, A., Lott, J., Lovell, D., Luijten, M., Marchetti, F., Nicolette, J., Pfuhler, S., Roberts, D., Stankowski, L., Thybaud, V., Weiner, S., Williams, A., Witt, K., Young, R. A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals Mutation Research/Genetic Toxicology and Environmental Mutagenesis 839 21 35
  4. Pottenger, L., Boysen, G., Brown, K., Cadet, J., Fuchs, R., Johnson, G., Swenberg, J., Johnson, G. Understanding the importance of low‐molecular weight (ethylene oxide‐ and propylene oxide‐induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions Environmental and Molecular Mutagenesis
  5. White, P., Zeller, A., Pfuhler, S., Johnson, G. Re: Gi et al. 2018, In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats, Archives of Toxicology 92:3207–3221 Archives of Toxicology
  6. Pottenger, L., Boysen, G., Brown, K., Cadet, J., Fuchs, R., Johnson, G., Swenberg, J., Johnson, G. Understanding the importance of low‐molecular weight (ethylene oxide‐ and propylene oxide‐induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions Environmental and Molecular Mutagenesis
  7. Wills, J., Johnson, G., Battaion, H., Slob, W., White, P. Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay Environmental and Molecular Mutagenesis
  8. Wills, J., Johnson, G., Doak, S., Soeteman-Hernández, L., Slob, W., White, P. Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations Mutagenesis 31 3 255 263
  9. Wills, J., Long, A., Johnson, G., Bemis, J., Dertinger, S., Slob, W., White, P. Empirical analysis of BMD metrics in genetic toxicology part II:in vivopotency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment Mutagenesis 31 3 265 275
  10. White, P., Johnson, G. Genetic Toxicology at the Crossroads – From Qualitative Hazard Evaluation to Quantitative Risk Assessment Mutagenesis 31
  11. White, P., Johnson, G. Genetic toxicology at the crossroads—from qualitative hazard evaluation to quantitative risk assessment Mutagenesis 31 3 233 237
  12. Johnson, G., Yamamoto, M., Suzuki, Y., Adachi, H., Kyoya, T., Takasawa, H., Horibata, K., Tsutsumi, E., Wada, K., Kikuzuki, R., Yoshida, I., Kimoto, T., Maeda, A., Narumi, K. Measuring Reproducibility of Dose Response Data for the Pig-a Assay using Covariate Benchmark Dose Analysis Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  13. Dearfield, K., Gollapudi, B., Bemis, J., Benz, R., Douglas, G., Elespuru, R., Johnson, G., Kirkland, D., LeBaron, M., Li, A., Marchetti, F., Pottenger, L., Rorije, E., Tanir, J., Thybaud, V., van Benthem, J., Yauk, C., Zeiger, E., Luijten, M. Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations Environmental and Molecular Mutagenesis
  14. Rees, B., Tate, M., Lynch, A., Thornton, C., Jenkins, G., Walmsley, R., Johnson, G. Development of an in vitro PIG-A gene mutation assay in human cells Mutagenesis 32 2 283 297
  15. Verma, J., Rees, B., Wilde, E., Thornton, C., Jenkins, G., Doak, S., Johnson, G. Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells Archives of Toxicology
  16. Guérard, M., Johnson, G., Dertinger, S., Duran-Pacheco, G., Funk, J., Zeller, A., Johnson, G. Dose–response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay Archives of Toxicology
  17. Klapacz, J., Pottenger, L., Engelward, B., Heinen, C., Johnson, G., Clewell, R., Carmichael, P., Adeleye, Y., Andersen, M. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents Mutation Research/Reviews in Mutation Research
  18. Tweats, D., Johnson, G., Scandale, I., Whitwell, J., Evans, D. Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity Mutagenesis 31 3 309 321
  19. Soeteman-Hernández, L., Fellows, M., Johnson, G., Slob, W. Correlation of in vivo versus in vitro benchmark doses (BMDs) derived from micronucleus test data: A proof of concept study Toxicological Sciences 148 2 355 367
  20. Avancini, D., Menzies, G., Morgan, C., Wills, J., Johnson, G., White, P., Lewis, P. MutAIT: an online genetic toxicology data portal and analysis tools Mutagenesis gev050

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  • PM-120 Skills for Geneticists I

    This module is designed to develop the skills required for students of genetics and medical genetics. Students will meet with tutors and be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint sessions will cover generic skills such as internet searching for scientific sources, referencing and plagiarism.

  • PM-200 Skills For Geneticists II

    This module will give assignments designed to build on essay writing and oral presentation skills introduced in level 1. It will also develop critical evaluation, analysis skills for the understanding of peer-reviewed research papers.

  • PM-226 Human and Medical Genetics

    The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project


  • PM-316 Genetic Toxicology

    The module provides an advanced understanding of the effects of carcinogenic agents on human health, and develops skills in investigating and assessing DNA damage caused by genotoxic compounds to improve the prevention and treatment of cancer and human disease.

  • PM-E01 Placement Year

    On successful completion of the industrial placement year, the student should: have gained first-hand experience of working in a commercial scientific research and development team, appreciate the differences between an academic and industrial working environment.


  • Analysis and Toxicological Assay Development Following the Assessment of Micronuclei Induction and Immune Response Pathways in Chemo-Sensitive and Chemo-Resistant Ovarian Cancer Models (current)

    Other supervisor: Dr James Cronin
    Other supervisor: Dr George Johnson
  • Multiplexed in vitro assay for genetic toxicology screening (current)

    Other supervisor: Prof Paul Rees
    Other supervisor: Dr James Cronin
    Other supervisor: Dr George Johnson
  • Investigating the genotoxicity of N-nitrosodimethylamine (NDMA) coupled with automated scoring of the micronucleus assay after using imaging flow cytometry. (current)

    Other supervisor: Dr James Cronin
    Other supervisor: Dr George Johnson
  • Application of Benchmark Dose analysis to in vitro genotoxicity data for compound risk characterisation (current)

    Other supervisor: Dr James Cronin
    Other supervisor: Dr George Johnson
  • Dtermining the efficacy of products for bacterial biofilm prevention and removal for the wet leisure industry (awarded 2019)

    Other supervisor: Dr George Johnson
    Other supervisor: Dr Geertje Van Keulen

Administrative Responsibilities

  • Enterprise & Innovation Committee Member - College of Medicine

    2013 - Present

  • Director of Employability and Entrepreneurship - College of Medicine

    2012 - Present

  • Learning & Teaching Committee Member - College of Medicine

    2011 - Present

  • Genetics & Biochemistry Board of Studies Member - College of Medicine

    2007 - Present

  • Chair - Student Staff Consultative Committee - College of Medicine

    2011 - 2013

  • Member - Collaborative Provision Committee

    2014 - Present

  • Member - HEAR Steering Team

    2013 - Present

  • Member - Entrepreneurial Learning City Region Steering Group

    2014 - Present

  • Member - University - Committee for Research & Innovation Strategy

    2016 - Present

External Responsibilities

Research Groups

  • Genetic Toxicology Quantitative Research

    This Swansea based group links to international groups including the ILSI-HESI GTTC quantitative group and the IWGT 2013 quantitative group, both of which Dr George Johnson takes a leading role on, and both of which show global impact through their membership and publications. The aim of the GTQR group is to use Genetic Toxicology data in a more quantitative manner for human health risk assessment, and the work to date has initiated this paradigm shift, with the group now building on this success.

  • In Vitro Toxicology (DNA Damage) Research

    The in vitro Toxicology (DNA Damage) Research group is led by Professor Gareth Jenkins, Dr Shareen Doak and Dr George Johnson and aims to develop in vitro approaches to assess the hazards and risks posed to our genome from exposure to both natural and man-made agents.