Dr Ed Dudley
Associate Professor
Medicine
Telephone: (01792) 295378
Room: Academic Office - 121
First Floor
Institute of Life Science 1
Singleton Campus

Ed’s main research focus is in biomarker discovery utilising modern metabolomic and proteomic approaches. The research utilises a targeted hypothesis-driven approach with respect to his work on urinary modified nucleosides as prospective early diagnostic biomarkers of various cancers, whilst global unbiased biomarker discovery techniques have been applied to novel biomarker discovery in other diseases and disorders such as psychiatric conditions. Ed’s research sits across the “Devices” and the “‘Biomarkers and Genes’ Themes within the Medical School as the optimisation of mass spectrometric and allied techniques is also a main area of research. Ed is a lecturer for our Biochemistry Degree programme.

Collaborative research Ed undertakes currently involves the application of metabolomics and proteomics to a wide range of research areas, including novel antibiotics and antifungal agent discovery, understanding soil hydrophobicity, exploring fungal species interactions during wood decay and the development of novel theranostics.

Areas of Expertise
• Mass spectrometry
• Metabolomics / Proteomics
• Analytical Biochemistry

Publications

  1. & Distinct mechanisms by which two forms of miR-140 suppress the malignant properties of lung cancer cells. Oncotarget 9(92)
  2. & Multiplatform metabolome and proteome profiling identifies serum metabolite and protein signatures as prospective biomarkers for schizophrenia. Journal of Neural Transmission
  3. & Conidia of the insect pathogenic fungus, Metarhizium anisopliae, fail to adhere to mosquito larval cuticle. Royal Society Open Science 1(2), 140193-140193.
  4. & Phosphoproteomic Techniques and Applications. In Proteomics in Biomedicine and Pharmacology. -69).
  5. & Metarhizium anisopliae Pathogenesis of Mosquito Larvae: A Verdict of Accidental Death. PLoS ONE 8(12), e81686

See more...

Teaching

  • PM-000 Foundation Biological Chemistry

    The module will provide the student with a broad overview of biological chemistry in relation to molecules, their interactions and their roles within the human body. The module includes discussion of sugars, lipids, amino acids, DNA / RNA proteins and enzymes and provides the biological context of these molecules.The module is supported by 1 practical session, a calculations session and an essay submission with academic support.

  • PM-001 Metabolism and Homeostasis

    The module will provide the student with a broad overview of dietary requirements, digestion processes and associated anatomy, nutrient uptake and energetic metabolism processes within the human body. The catabolism of biomolecules for energy production will be covered and the role of the kidney in removal of by-products. The role of neuronal and hormonal systems in homeostatic control of the body will also be elaborated.

  • PM-008 Foundation Applied Medical Sciences Skills Development 2

    The module will provide the student with a diversity of laboratory and scientific skills in relation to the undertaking of undergraduate practical sessions in a safe manner and develop skills including molarity calculations, biological extractions, basic chromatography, an introduction into anatomical dissection and physiology.

  • PM-130 Biochemistry Skills Development

    This module is designed to develop the skills required for students of biochemistry and medical biochemistry. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint session cover generic skills such as internet searching for scientific sources, referencing and plagiarism

  • PM-131 Chemistry of Life

    The module provides a broad study of the interactions between chemical processes and biological systems. It addresses the chemical processes used by organisms to utilize chemicals for energy production, structural functions and as building blocks of macromolecules.

  • PM-230 Selected Medical Diagnostic Techniques

    This module looks at the design and operation of a wide range of instrumentation used to make measurements for diagnostic and monitoring purposes. The emphasis is on the underlying electrical, mechanical, chemical, optical and other engineering principles.

  • PM-245 Metabolic Regulation: Enzymes & Signal Transduction

    This module reviews the basic elements of enzyme kinetics, including their mechanism and inhibition. The control of enzyme function by allosteric mechanisms is considered together with an appreciation of the significance of sigmoid kinetics. An overview of coenzymes and (metal) co-factors in enzyme function is given together with a description of the role played by vitamins in co-enzyme production. The module concludes with an overview of enzymes from extremophiles and their applications.

  • PM-246 Biochemistry Skills Development II

    This module is designed to develop the skills required for students of biochemistry. Students meet with tutors and will be given a series of assignments designed to develop skills in key areas including essay writing, presentation and analysis of research papers.

  • PM-246C Datblygu Sgiliau Biocemeg II

    Nod y modiwl hwn yw datblygu'r sgiliau mae eu hangen ar fyfyrwyr biocemeg. Bydd myfyrwyr yn cwrdd â thiwtoriaid ac yn derbyn cyfres o aseiniadau at ddiben datblygu eu sgiliau mewn meysydd allweddol, gan gynnwys ysgrifennu traethodau, cyflwyno a dadansoddi papurau ymchwil.

  • PM-248 Amino acids, lipids and steroids

    The module reviews the pathways of fatty acid degradation (beta-oxidation) before describing the biochemistry of the multi-functional proteins that catalyse the formation of fatty acids. The mechanisms of fatty acid elongation and desaturation are covered along with the synthesis of triacylglycerols and glycerophospholipids with consideration being being given to the control of these pathways. The synthesis of cholesterol via the mevalonate pathway is described along with the various metabolic control points and an understanding of dietary lipid transport. The further metabolism of cholesterol to bile salts, steroid hormones and vitamin D is outlined with consideration given to the stereochemistry of these compounds. The module provides a sound basis for understanding the metabolism of amino acids, lipids and steroids. The pathways of amino acid synthesis and degradation in humans are described along with an introduction to the urea cycle.

  • PM-253 Techniques in Molecular Biology

    The module will provide a sound theoretical and practical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.

  • PM-253C Technegau Bioleg Foleciwlaidd

    Bydd y modiwl yn darparu sylfaen ddamcaniaethol ac ymarferol gref ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoir pwyslais penodol ar dechnoleg ailgyfuno DNA, dilyniannu cenhedlaeth nesaf, transgriptomeg, proteomeg a sbectrometreg màs.

  • PM-304 Biomolecular Research Project

    *

  • PM-330 Nucleic acids: components, metabolism and modification

    The module provides an understanding of the metabolism of nucleic acids and the biological relevance of their natural modification. The use of modified nucleic acid products clinically is also covered.

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-357 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PM-357C Technegau Labordy Biofeddygol

    Bydd y modiwl yn darparu damcaniaeth ymarferol a manwl o¿r cymwysiadau ac offer sydd ar gael i fyfyrwyr MSci yn y labordai ymchwil biofeddygol sydd wedi'u lleoli yn yr Ysgol Feddygaeth. Bydd y modiwl yn darparu canllawiau a rhesymeg ar gyfer cynlluniau arbrofol, a dadansoddiad data ac ystadegau.

  • PMGM12 Omics Techniques and their Application to Genomic Medicine

    This module explores the state of the art genomics techniques used for DNA sequencing (e.g. targeted approaches, whole exome and whole genome sequencing) and RNA sequencing. This module will include introductory bioinformatics approaches required for the analysis of genomic data, which will provide a solid foundation for the Bioinformatics module. The module will also cover the use of array based methodologies and RNA sequencing in estimating levels of protein expression, micro RNAs and gene manipulation technologies. A comprehensive introduction to metabolomics and proteomics, which are important for the functional interpretation of genomic data and discovery of disease biomarkers will also be included.

  • PMLM01 Separation science and sample handling

    This module will enable students to understand the basic and advanced concepts of separation science, how it is integrated with several forms of compound detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to compound chemical characteristics and method application.

  • PMLM05 LC/MS Applications IV: Medical and life sciences

    Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.

Supervision

  • Disrupting the diagnostic paradigm for gestational diabetes using blood-based Raman spectroscopy. (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
  • A study into plant essential oils, their antibacterial effects and their potential synergy when combined with antibiotics (current)

    Student name:
    MSc
    Other supervisor: Dr Paula Row
  • no changes required to the thesis title (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
  • Metabolite profiling of a robust strain of cyanobacterium for industrial biotechnology (current)

    Student name:
    PhD
    Other supervisor: Dr Carole Llewellyn
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Joel Loveridge
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
  • 'Whose wood is it anyway? Interspecific interactions between saprotrophic Agaricomycetes and the impact on wood decomposition' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Dan Eastwood
  • 'Unbiased and targeted metabolomic approaches to biomarker discovery for pancreatic cancer' (awarded 2018)

    Student name:
    MSc
    Other supervisor: Dr Claire Morgan
  • 'The Development and Optimisation of Analytical Techniques to Analyse Ceramide in an Attempt to Determine its Potential Physiological Role in Apoptotic Processes.' (awarded 2017)

    Student name:
    MSc
    Other supervisor: Dr Nigel Francis

External Responsibilities

  • Editorial Board Member, Journal of Molecular Psychiatry

    2014 - Present

  • Editorial Board Member, Journal of Integrated Omics

    2014 - Present

  • Member, NERC Peer Review College

    2014 - Present

Administrative Responsibilities

  • Member - College of Medicine Research Committee

    2012 - Present

  • Member - College of Medicine Undergraduate Teaching Board

    2007 - Present

  • Chair - College of Medicine Special Circumstances Committee

    2014 - Present