I studied both my BSc and MSc in Biomedical Science in University of Wales Institute, Cardiff, specialising in Forensic Toxicology and Medical Microbiology. Following this I was fortunate enough to be awarded a NISCHR Welsh Office of Research and Development PhD (2009), investigating the role of exercise in preventing the progression of Type 2 diabetes and associated cardiovascular effects e.g. atherosclerosis and cell polarisation effects. This allowed me the opportunity to carry out in vivo projects and develop a keen interest in the effects of inflammation on cell signalling pathways and their role in disease progression.

My time as a post-Doctoral researcher was spent in the Haemostasis Biomedical Research Unit, investigating the role of inflammation in haemostasis and how this varies in hypo- and hyper-coagulable states. Based in an Emergency Department in Morriston Hospital, I developed a keen interest in Emergency Medicine Research and was involved in a number of studies investigating the role of haemostasis in stroke, cardiac, sepsis and burns patients. I successfully led and completed a project investigating the changes in haemostasis in patients with lung cancer, quantifying changes to clot structure using a cutting edge haemorheological technique, developed here in Swansea University between Medical School and the College of Engineering.

Currently I am director of the Foundation Year for the BSc Applied Medical Sciences degree programme, aiming to widen access to Higher Education. In addition I am a lecturer and disability link tutor on the BSc Applied Medical Sciences, co-ordinating and contributing to several modules including laboratory skills, anatomy, physiology and pathophysiology.  

Publications

  1. Davies, N., Noble, S., Harrison, N., Morris, R., Evans, P., Davies, N. PO-25 - FATCAT: an observational cohort study investigating fractal dimension (df) as a biomarker of thrombogenicity in cancer associated thrombosis during chemotherapy for lung cancer Thrombosis Research 140 S185
  2. Davies, N., Healy, M., Fletcher, J., Croxall, J., Wallace, L. Assessment of practical skills in undergraduate medical science students
  3. Wallace, L., Davies, N., Fletcher, J., Healy, M., Croxall, J. Doctors for Wales: a prospective study of feeder stream course undergraduates
  4. Moir, H., Hughes, M., Potter, S., Sims, C., Butcher, L., Davies, N., Verheggen, K., Jones, K., Thomas, A., Webb, R., Davies, N. Exercise-induced immunosuppression: roles of reactive oxygen species and 5'-AMP-activated protein kinase dephosphorylation within immune cells Journal of Applied Physiology 108 5 1284 1292
  5. Davies, N., Watkeys, L., Butcher, L., Potter, S., Hughes, M., Moir, H., Morris, K., Thomas, A., Webb, R., Davies, N. The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells Free Radical Research 49 1 45 56

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Teaching

  • PM-002 The Human Cell

    This module aims to give students a broad overview of the structure and function of components of the human body, from cells and their organisation to the function of specialised cells in various organs. The role of the specialised cells will be explored using blood as an example. Students will also obtain an appreciation of the cancer cell proliferation and the various causes of leukaemias.

  • PM-003 Introduction to Molecular Biology

    This module will provide the learner with an introduction to molecular biology, classification of species and its applications in medical science. The concept of evolution and sexual reproduction and development will also be covered, and the processes of inheritance and genetic variation, particularly with regard to evolution and natural selection. This module will be supported by a practical session and essay with academic support on a topic relevant to the medical applications of molecular biology.

  • PM-138 Skills for Medical Sciences

    The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.

  • PM-138C Sgiliau ar gyfer Gwyddorau Meddygol

    Nod y modiwl hwn yw darparu¿r sgiliau sylfaenol sydd eu hangen ar fyfyrwyr ar gyfer ymchwil labordy ym maes y gwyddorau meddygol cymhwysol. Bydd y modiwl yn cynnwys gwaith damcaniaethol a chymhwysol: caiff y myfyriwr ei hyfforddi mewn dulliau sy¿n hanfodol ar gyfer caffael data a¿i ddadansoddi, ond bydd hefyd yn cymryd rhan weithredol yn y labordy, gan ddefnyddio¿n fras y technegau arbrofol perthnasol. Byddant hefyd yn datblygu sgiliau nad ydynt yn dechnegau arbrofol yn eu hunain, ond sydd er hynny, yn sylfaenol i¿r broses wyddonol, megis, mathemateg y labordy¿, cyrchu gwybodaeth, cyfeirnodi, moeseg ac iechyd a diogelwch.

  • PM-147 The Dose Makes the Poison: Intro to Toxicology and Dose Response

    We are surrounded by substances that may do our bodies harm ¿ poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module will provide you with an introduction to toxicology and how dose-response relationships relate to the physiological effects of toxic substances. You will explore how they produce cellular and chemical changes that cause tissues and organs to malfunction. You will learn how the structure and function of these tissues can be affected to varying degrees and begin to understand how tissue may repair itself and when the damage is permanent or fatal.

  • PM-226 Human and Medical Genetics

    The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.

  • PM-254 Doctors, patients & the goals of medicine

    TBC

  • PM-259 Contemporary themes and techniques in medical sciences

    This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the zika virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases. The module will also involve a one-day "conference", during which students will present data while experiencing a research conference atmosphere.

  • PM-259C Themâu a thechnegau cyfoes yn y gwyddorau meddygol

    Nod y modiwl hwn yw rhoi trosolwg i fyfyrwyr o'r themâu presennol a'r rhai sy'n datblygu yn y gwyddorau meddygol, o safbwynt clinigol a'r labordy. Bydd yn ymdrin â phynciau sy'n denu sylw sylweddol yn y cyfryngau, megis y firws Zika a dulliau trawsblannu amgen yn ogystal â thechnegau labordy newydd. Yn ogystal, ategir y modiwl gan ddau ddosbarth ymarferol - disgwylir i fyfyrwyr ymgymryd â phrosiectau bach ar sail dadansoddi samplau cleifion, a sut caiff y rhain eu cyflwyno fel astudiaethau ymchwil. Bydd y modiwl hefyd yn cynnwys 'cynhadledd' undydd pan fydd myfyrwyr yn cyflwyno data ac yn cael profiad o awyrgylch cynhadledd ymchwil.

  • PM-265 Population Health Management, Solutions and Strategies

    Population Health Management (PHM) is concerned with the organisation and management of healthcare delivery systems in a manner that makes it more clinically effective, more cost effective, and safer. This module examines established Population Health Management approaches and the strategies required to create a balance between the often competing interests of clinicians, funding bodies, managers and patients.

  • PM-267 Genes on Drugs: Pharmacogenomics

    Genes affect how the body reacts to drugs as well as how they are absorbed, metabolized and eliminated. You will learn how variation in genes encoding proteins involved in these processes affect how drugs work ¿ or don¿t ¿ therapeutically. By understanding these factors, you will gain insight into the emerging field of personalized medicine and learn how individualized drug design and selection can improve therapeutic efficacy, safety and sustainability.

  • PM-269 Population Health & The Art of Research 1

    This module introduces students to the philosophical underpinnings, and practical applications of population health research. It has been designed to enable students to develop a real-world understanding of a range of epidemiological and qualitative research methodologies used to investigate population health problems, and an appreciation of the importance of ethics when conducting population health research in practice.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-344C Prosiect Capfaen

    Nod y modiwl hwn yw rhoi cyfle i fyfyrwyr gael profiad dysgu capfaen drwy gymryd rhan yn eu prosiect eu hunain yn seiliedig ar gwestiwn ymchwil. Gan ddibynnu ar linyn cyflogadwyedd y myfyriwr yn y rhaglen, gall y prosiect fod yn seiliedig ar waith labordy, data neu addysg, ond bydd bob amser yn cynnwys cwestiwn ymchwil sy'n deillio o'r llenyddiaeth, ac sy'n canolbwyntio ar bwnc perthnasol i wyddor feddygol. Bydd yn gofyn cwestiwn ymchwil newydd ac yn cynnwys dadansoddiad beirniadol o ganfyddiadau ymchwil. Bydd myfyrwyr yn mireinio eu sgiliau cyfathrebu llafar ac ysgrifenedig i lefel raddedig, drwy lunio cyflwyniad rhagarweiniol ar gefndir y prosiect, ynghyd â thraethawd estynedig a chyflwyniad llafar ar ganfyddiadau eu hymchwil.

  • PM-353 From Bench to Beside: an Introduction to Clinical Trials

    Clinical trials are conducted to determine whether medical interventions, like treatment strategies or devices, are safe and effective in humans. This is an expanding and highly competitive field of research, yet employers find it challenging to recruit people with the appropriate skills and knowledge. Taught by leading researchers currently involved in these studies, in this module, you will gain an introduction to trial research methodology. Using real, published studies, you will be introduced to study design, conduct, analysis and critical appraisal. You will learn about early to late phase trials as well as simple versus complex design. You will also learn to recognise whether certain treatments are more or less effective in particular groups of people and learn about the responsible reporting of study outcomes

  • PMGM18 Critical Literature Review

    This module will allow students to carry out a critical and in-depth evaluation of previous research based on a specific subject related to genomics

  • PMGM21 Pharmacogenomics & Stratified Healthcare

    Pharmacogenomics and stratified health care ensure that healthcare professionals offer the 'right treatment, for the right person, at the right time¿ is a fast-developing area. `Personalised medicine¿ is the buzzword of the moment, with advances in pharmacogenomic testing enabling more effective, targeted therapies to patients in the field of asthma, analgesia, oncology and beyond. Continued understanding of the genomic basis of drug response will reduce drug-related adverse effects, save costs, and ensure a better therapeutic outcome. This module will provide a comprehensive overview of the analytical strategies and techniques used in pharmacogenomics and explore some of the challenges and limitations in this field. The module will also provide an overview of the different type of pharmacogenomic biomarkers currently in use or emerging and the current feasibility of delivering `personalised medicine¿ in the clinic.