I received my BSc in Medical Pharmacology in 2012 and my PhD in Cardiovscular Biology in 2016 from Cardiff University School of Medicine. My doctoral research focused on the characterisation of adipocyte-derived extracellular vesicles (EVs) which are submicron blebs of fat cells. I utlised adipocyte cell lines to compare the production of adipocyte EVs compared to their cell of origin under physiological and pathophysiological conditions. I continued this research into my post-doctoral position at Cardiff Metropolitan University where I focused on the potential functions of adipocyte-derived extracellular vesicles in cardiovascular disease. I isolated primary leukocytes and primary endothelial cells to study the potential inflammatory actions of adipocyte EVs derived from obese adipocytes . I also undertook work to evidence the existence of adipocyte-derived EVs in the human circulation.

Teaching

  • PM-003 Introduction to Molecular Biology

    This module will provide the learner with an introduction to molecular biology, classification of species and its applications in medical science. The concept of evolution and sexual reproduction and development will also be covered, and the processes of inheritance and genetic variation, particularly with regard to evolution and natural selection. This module will be supported by a practical session and essay with academic support on a topic relevant to the medical applications of molecular biology.

  • PM-007 Foundation Applied Medical Sciences Skills Development 1

    The module will provide the student with a diversity of study, laboratory and scientific skills in relation to the undertaking of undergraduate practical sessions in a safe manner. This will involve the development of skills including basic biologically relevant mathematics, appropriate data handling, working safely and key laboratory skills. Students will also be provided with an introduction to laboratory methods such as accurate pipetting and standard curve construction. In addition, students will receive lectures on developing study skills in literature searching, referencing & plagiarism and communication of information.

  • PM-138 Skills for Medical Sciences

    The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.

  • PM-140 Anatomy

    This module will help to discover the anatomy of the human body in a systems based approach (cardiovascular, gastrointestinal, musculo-skeletal, respiratory and nervous systems). Anatomy is a fundamental science and supports many areas of biology and medicine. As such, the topics chosen for this module are those most useful to other areas of biological science, with clinical significance. This module will be delivered through lectures and practical classes with demonstrators leading practical and self-studying activities. Support materials and laboratory space for self-directed learning, including prosections, plastic anatomical models, bones and skeletons, and computer based anatomical models will be available.

  • PM-147 The Dose Makes the Poison: Intro to Toxicology and Dose Response

    We are surrounded by substances that may do our bodies harm ¿ poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module will provide you with an introduction to toxicology and how dose-response relationships relate to the physiological effects of toxic substances. You will explore how they produce cellular and chemical changes that cause tissues and organs to malfunction. You will learn how the structure and function of these tissues can be affected to varying degrees and begin to understand how tissue may repair itself and when the damage is permanent or fatal.

  • PM-250 Infectious Disease and Parasitology

    The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

  • PM-259 Contemporary themes and techniques in medical sciences

    This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the zika virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases. The module will also involve a one-day "conference", during which students will present data while experiencing a research conference atmosphere.

  • PM-340 Being a Medical Scientist

    Much of a scientist¿s career is spent writing and speaking about science. The aim of this module is to give students a higher level experience of what being a lead researcher is like, away from the lab bench. Drawing on core knowledge from other modules, students will refine their oral and written communication and learn what leadership skills are needed to succeed in modern science. They will also be challenged to consider ethical aspects of research, including new technologies and the use of animal and human subjects. The module will be highly interactive, taught using informal lectures interspersed with students working in groups. Assessments will include an ethics application, a group Journal Club presentation on a published, peer-reviewed research article, and a mock grant proposal.

  • PM-342 Advances in Pharmacology

    Pharmacology is the science of how drugs act on the body and how the body acts on drugs. Pharmacology investigates the chemical and physical properties of drugs, how those properties confer actions on living tissues and how those actions affect health and disease. The beneficial, therapeutic effects of drugs will be discussed, but also some negative consequences of drug administration, such as toxicity, addiction and microbial drug-resistance.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.