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I received my BSc in Medical Pharmacology in 2012 and my PhD in Cardiovscular Biology in 2016 from Cardiff University School of Medicine. My doctoral research focused on the characterisation of adipocyte-derived extracellular vesicles (EVs) which are submicron blebs of fat cells. I utlised adipocyte cell lines to compare the production of adipocyte EVs compared to their cell of origin under physiological and pathophysiological conditions. I continued this research into my post-doctoral position at Cardiff Metropolitan University where I focused on the potential functions of adipocyte-derived extracellular vesicles in cardiovascular disease. I isolated primary leukocytes and primary endothelial cells to study the potential inflammatory actions of adipocyte EVs derived from obese adipocytes . I also undertook work to evidence the existence of adipocyte-derived EVs in the human circulation.

Teaching

  • PM-001 Metabolism and Homeostasis

    The module will provide the student with a broad overview of dietary requirements, digestion processes and associated anatomy, nutrient uptake and energetic metabolism processes within the human body. The catabolism of biomolecules for energy production will be covered and the role of the kidney in removal of by-products. The role of neuronal and hormonal systems in homeostatic control of the body will also be elaborated.

  • PM-007 Foundation Applied Medical Sciences Skills Development 1

    The module will provide the student with a diversity of study, laboratory and scientific skills in relation to the undertaking of undergraduate practical sessions in a safe manner. This will involve the development of skills including basic biologically relevant mathematics, appropriate data handling, working safely and key laboratory skills. Students will also be provided with an introduction to laboratory methods such as accurate pipetting and standard curve construction. In addition, students will receive lectures on developing study skills in literature searching, referencing & plagiarism and communication of information.

  • PM-138 Skills for Medical Sciences

    The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.

  • PM-138C Sgiliau ar gyfer Gwyddorau Meddygol

    Nod y modiwl hwn yw darparu¿r sgiliau sylfaenol sydd eu hangen ar fyfyrwyr ar gyfer ymchwil labordy ym maes y gwyddorau meddygol cymhwysol. Bydd y modiwl yn cynnwys gwaith damcaniaethol a chymhwysol: caiff y myfyriwr ei hyfforddi mewn dulliau sy¿n hanfodol ar gyfer caffael data a¿i ddadansoddi, ond bydd hefyd yn cymryd rhan weithredol yn y labordy, gan ddefnyddio¿n fras y technegau arbrofol perthnasol. Byddant hefyd yn datblygu sgiliau nad ydynt yn dechnegau arbrofol yn eu hunain, ond sydd er hynny, yn sylfaenol i¿r broses wyddonol, megis, mathemateg y labordy¿, cyrchu gwybodaeth, cyfeirnodi, moeseg ac iechyd a diogelwch.

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.

  • PM-150 Introductory Biochemistry

    The module provides a broad study of the interactions between chemical processes and biological systems. It addresses the chemical processes used by organisms to utilize chemicals for energy production, structural functions and as building blocks of macromolecules.

  • PM-250 Infectious Disease and Parasitology

    The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

  • PM-250C Clefydau Heintus a Pharasitoleg

    Bydd y cwrs yn adeiladu ar sylfeini microbioleg ac yn cyflwyno pynciau newydd ym meysydd bacterioleg, mycoleg a pharasitoleg. Mae Imiwnoleg Lefel 5 (PM-249) yn rhagofyniad. Mae'r cwrs yn ymdrin ag egwyddorion sylfaenol clefydau heintus, gan gynnwys agweddau clinigol, triniaeth/atal, ac ymagweddau arbrofol at astudio organebau heintus a pharasitig. Bydd y cwrs hefyd yn ymdrin â phynciau gan gynnwys achosion o glefydau, parasitiaid buddiol, clefydau trofannol a pharasitiaid sy'n effeithio ar ymddygiad.

  • PM-254C Meddygon, Cleifion a Nodau Meddygaeth

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  • PM-256 Communicating Medical Sciences

    An important aspect of the role of scientists concerns the communication of complex scientific ideas and research to non-specialist audiences. This module will explore methods of science communication including public events and campaigns and through digital and social media. There will be a focus on visual communication techniques (such as digital storytelling and infographics) to facilitate engagement and presentation of information for different audiences. Students will be required to create a poster, write an abstract, and write and deliver a podcast (digital audio file).

  • PM-266 The Cardiovascular System

    Leading on from the first year Human Physiology Module (PM-139), the Cardiovascular Module will introduce and define the fundamental cellular mechanisms that regulate the physiology of healthy cardiovascular function. The Module will describe the processes that allow regular heartbeat and blood vessel function and how perturbations in the systems covered may lead to pathophysiological conditions. There will be an emphasis on experimental approaches used to study the cardiovascular mechanisms described.

  • PM-338 Teaching Science In Schools

    This module is for students with an interest in entering teaching, and involves placements in local schools The student will engage both in observation and in various teaching activities. The module will be assessed through various methods including a written report and the teachers report.

  • PM-340 Being a Medical Scientist

    Much of a scientist¿s career is spent writing and speaking about science. The aim of this module is to give students a higher level experience of what being a lead researcher is like, away from the lab bench. Drawing on core knowledge from other modules, students will refine their oral and written communication and learn what leadership skills are needed to succeed in modern science. They will also be challenged to consider ethical aspects of research, including new technologies and the use of animal and human subjects. The module will be highly interactive, taught using informal lectures interspersed with students working in groups. Assessments will include an ethics application, a group Journal Club presentation on a published, peer-reviewed research article, and a mock grant proposal.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-352 Reproductive Biology and Medicine

    This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility and menopause.

  • PM-354 Cancer Pharmacology

    Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.