Fundamental Genetics and Evolution
The module will provide a foundation in genetics and evolution. Concepts such as DNA discovery, structure and replication, gene transcription and translation, mechanisms of gene transmission, genome organisation, epigenetic modifications and mutations will be covered with an appreciation of how how these mechanisms have an impact on human disease and antibiotic resistance.
The latter part of the module will start with the work of Plato, Cuvier, Lamarck, Wallace and Darwin and how they (and others) influenced the development of an evolutionary theory framework. Using this knowledge the module will then look at the processes involved in speciation and how they can be applied at both the gene and whole organismal level.
Population genomics is the study of genetic variation within populations and involves the examination of changes in the frequency of gene and alleles across space and time. Concepts such as natural selection, genetic drift, gene pool, genetic diversity, migration and environmental diversity all contribute to create genetic diversity within sub populations. Students will be taught these key concepts along with the real life sub populations examples where genotype variation has led to the diversity in genetics. Such as, the prevalence of disease in the specific populations, the evolution of genetically distinct populations and the genomics behind genetic diversity in sport. This module will take you across the world in multidisciplinary topics and show how genomics is weaved throughout, to create the strengths, weakness, and purely, what makes us who we are.
Doctors, patients & the goals of medicine
The educational intention of the module is to allow the student to consider the contemporary practice of Medicine
within the United Kingdom. This will include understanding the professional regulation, financial constraints and
societal and personal challenges, within which medicine and other healthcare activities are practiced.
Meddygon, Cleifion a Nodau Meddygaeth
Bwriad addysgol y modiwl yw caniatáu i'r myfyriwr ystyried arfer cyfoes Meddygaeth yn y Deyrnas Unedig. Bydd hyn yn cynnwys deall y rheoleiddiad proffesiynol, cyfyngiadau ariannol a'r heriau cymdeithasol a phersonol, y mae meddygaeth a gweithgareddau gofal iechyd eraill yn cael eu hymarfer ynddynt.
Pharmacogenomics: Genes on Drugs
Pharmacogenomics is the study of how a person¿s genomic information can affect their response to drugs and therapeautics, predicting if a patient will response badly, too much or too little to a chosen therapy. This is the underlying principle of `personalised medicine¿, ensuring the right patient, gets the right drug, at the right time.
Within this module, students will look at the principles of pharmacogenomics, namely the variation in genomics sequences from patients to patients which can alter the pharmacokinetics and pharmacodynamics of therapeutics. In this module,
students will learn about the role of pharmacogenomics in chemotherapy, gastrointestinal drugs, cardiovascular drugs, respiratory drugs, neurological drugs and drugs used in treatment of infectious disease.
Genetics of Cancer
This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.
Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.
Advanced Research Project B
The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference.
The advanced research project is divided between 2 modules, PM-400 and PM-402. PM-402 comprises the final written dissertation.
Ethical, Legal and Societal Issues (ELSI) in Applied Genomics
This module will provide students with an understanding of the legal, regulatory & governance frameworks associated with medical genomics and the use of genomic data. It will equip students to explore and evaluate the main ethical, legal and social issues (ELSI) involved in: genomic testing and the wider implications for the patient and their families; precision medicine; and the use of genomic data for population research.
This module covers the molecular mechanisms that underlie cancer development, growth and metastasis, and the differences between different cancers. It will explore the different molecular and cellular actions of anti-cancer treatments, the genomic factors affecting response and resistance to treatment, and the research approaches to anti-cancer drug design and development. Broad situations which confer a high cancer risk to a person and/or to other members of the same family will be discussed in the context of how genomic information may be integrated into cancer screening programmes. This module will prepare the students to interrogate the cancer data sets from the 100,000 Genomes Project as well as to interrogate cancer genomic datasets in general.
Genomics of Common and Rare Inherited Disease
This module will provide an introduction to the clinical presentation and manifestations of rare inherited and common diseases, and considers the patient and family perspective with respect to the role and impact of genomics. It reviews traditional and current strategies and techniques used to identify genes responsible for both common multifactorial and rare inherited diseases.
The module is for students to build on their previous knowledge, skills and experience by undertaking a laboratory based or suitable non-laboratory based project on a specific subject related to genomics.