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Dr Nicholas Jones

Lecturer, Biomedical Sciences

Telephone number

+44 (0) 1792 513509

Email address

Research Links

Available For Postgraduate Supervision

About

Nick was awarded a PhD from Swansea University Medical School in 2017 investigating the role of metabolism in governing the human adaptive immune response. Nick has strong interests in the role of metabolism within the immune system, translating towards diseases such as cancer. Specifically, Nick aims to understand the role of dietary fuels and their impact on T-cell fitness and function in healthy and disease settings. The overall goal is translating the research towards a clinical setting to improve the efficacy of multiple immunotherapy strategies.

Areas Of Expertise

  • Immunometabolism
  • Cancer immunotherapy
  • Human immunology
  • Oncometabolism
  • T-cells

Career Highlights

Teaching Interests

Nick lectures on the Genetics and Biochemistry BSc and MSci degree programmes. Specifically, Nicks’ teaching focuses on research informed teaching contributing to modules such as Human Immunopathology, Genetics of Cancer, Biomedical Techniques and Science Communication (module coordinator). In addition, Nick takes pride in training BSc and MSci students during their final year research projects. Multiple former students within the lab have contributed as authors on scientific publications and gone on to pursue PhDs both internally and externally.

Research

Upon activation, human T-cells adopt an anabolic metabolism to fuel biosynthetic and energetic requirements. This metabolic rewiring supports blastogenesis and the production of other immune-based mediators such as cytokines to drive the adaptive immune response. Nicks’ research focuses on the metabolic plasticity of human T-cells that includes how T-cells adapt to nutrient restriction or manipulation using pharmacological approaches. Nick has a core interest in pushing away from traditional in vitro approaches, moving research towards ex vivo and in vivo approaches in order to gain a more accurate representation into the metabolic requirements of human T-cells. Currently, Nick is working on multiple approaches of understanding and optimizing immunotherapeutic strategies.

Collaborations

Nick has an active clinical collaboration with the haematology department at Swansea Bay University Health Board. 

Nick’s academic collaborations extend throughout the UK and worldwide including Ireland and the USA.