Dr Gareth Healey

Research Highlights

1. Healey, G., Conlan, S. 2017 Therapeutic Development and the Evolution of Precision Medicine (Ed.), Nanoscience and Nanotechnology for Human Health 359 378

   https://cronfa.swan.ac.uk/Record/cronfa33096

   http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527338608.html
2. Howard, D., Garcia-Parra, J., Healey, G., Amakiri, C., Margarit, L., Francis, L., Gonzalez, D., Conlan, R., Conlan, S., Garcia Parra, J. 2016 Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment Interface Focus 6 6 20160054

   https://cronfa.swan.ac.uk/Record/cronfa33095 doi: 10.1098/rsfs.2016.0054
3. Vitorino Carvalho, A., Reinaud, P., Forde, N., Healey, G., Eozenou, C., Giraud-delville, C., Mansouri-Attia, N., Gall, L., Richard, C., Lonergan, P., Sheldon, I., Lea, R., Sandra, O., Healey, G., Sheldon, M. 2014 SOCS genes expression during physiological and perturbed implantation in bovine endometrium Reproduction

   https://cronfa.swan.ac.uk/Record/cronfa18919 doi: 10.1530/rep-14-0214
4. Vitorino Carvalho, A., Eozenou, C., Healey, G., Forde, N., Reinaud, P., Chebrout, M., Gall, L., Rodde, N., Padilla, A., Delville, C., Leveugle, M., Richard, C., Sheldon, I., Lonergan, P., Jolivet, G., Sandra, O., Healey, G., Sheldon, M. 2014 Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium Reproduction, Fertility and Development

   https://cronfa.swan.ac.uk/Record/cronfa18917 doi: 10.1071/rd14034
5. Healey, G., Zinnen, S., Lockridge, J., Richards, I., Evans, N., Walker, W. 2010 Identification of small interfering RNA targeting Signal Transducer and Activator of Transcription 6: characterisation and selection of candidates for pre-clinical development Journal of RNAi and Gene Silencing 6 2 401 410

   https://cronfa.swan.ac.uk/Record/cronfa18794
6. Healey, G. 2006 Vaccine production and development: The challenges of realising a future free from disease Microbiologist 7 1 28 30

   https://cronfa.swan.ac.uk/Record/cronfa19234
7. Hill, J., Eyles, J., Elvin, S., Healey, G., Lukaszewski, R., Titball, R., Healey, G. 2006 Administration of Antibody to the Lung Protects Mice against Pneumonic Plague Infection and Immunity 74 5 3068 3070

   https://cronfa.swan.ac.uk/Record/cronfa18788 doi: 10.1128/IAI.74.5.3068-3070.2006
8. Elvin, S., Healey, G., Westwood, A., Knight, S., Eyles, J., Williamson, E., Healey, G. 2006 Protection against Heterologous Burkholderia pseudomallei Strains by Dendritic Cell Immunization Infection and Immunity 74 3 1706 1711

   https://cronfa.swan.ac.uk/Record/cronfa18787 doi: 10.1128/IAI.74.3.1706-1711.2006
9. Westwood, A., Elvin, S., Healey, G., Williamson, E., Eyles, J. 2006 Immunological responses after immunisation of mice with microparticles containing antigen and single stranded RNA (polyuridylic acid) Vaccine 24 11 1736 1743

   https://cronfa.swan.ac.uk/Record/cronfa18786 doi: 10.1016/j.vaccine.2005.10.021
10. Healey, G. 2005 Investigation of dendritic cells as a vector for vaccine delivery

    https://cronfa.swan.ac.uk/Record/cronfa19235

    http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418466
11. Healey, G., Elvin, S., Morton, M., Williamson, E., Healey, G. 2005 Humoral and Cell-Mediated Adaptive Immune Responses Are Required for Protection against Burkholderia pseudomallei Challenge and Bacterial Clearance Postinfection Infection and Immunity 73 9 5945 5951

    https://cronfa.swan.ac.uk/Record/cronfa18785 doi: 10.1128/IAI.73.9.5945-5951.2005
12. Westwood, A., Healey, G., Williamson, E., Eyles, J. 2005 Activation of dendritic cells by microparticles containing Bacillus anthracis protective antigen Vaccine 23 29 3857 3863

    https://cronfa.swan.ac.uk/Record/cronfa18784 doi: 10.1016/j.vaccine.2004.11.079
13. Walker, W., Healey, G., Hopkin, J., Walker, W., Healey, G. 2009 RNA interference of STAT6 rapidly attenuates ongoing interleukin-13-mediated events in lung epithelial cells Immunology 127 256 266

    https://cronfa.swan.ac.uk/Record/cronfa10002 doi: 10.1111/j.1365-2567.2008.02951.x
14. Borges, Á., Healey, G., Sheldon, I., Sheldon, M. 2012 Explants of Intact Endometrium to Model Bovine Innate Immunity and Inflammation Ex Vivo American Journal of Reproductive Immunology 67 6 526 539

    https://cronfa.swan.ac.uk/Record/cronfa11549 doi: 10.1111/j.1600-0897.2012.01106.x
15. Turner, M., Healey, G., Sheldon, I., Healey, G., Sheldon, M., Turner, M. 2012 Immunity and Inflammation in the Uterus Reproduction in Domestic Animals 47 402 409

    https://cronfa.swan.ac.uk/Record/cronfa13924 doi: 10.1111/j.1439-0531.2012.02104.x
16. Healey, G., Evans, N., Hopkin, J., Davies, G., Walker, W. 2013 Evaluation of nasal epithelium sampling as a tool in the preclinical development of siRNA-based therapeutics for asthma Journal of Cellular and Molecular Medicine 17 3 356 364

    https://cronfa.swan.ac.uk/Record/cronfa17098 doi: 10.1111/jcmm.12014
17. Walker, W., Healey, G. 2014 Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6 PLoS ONE 9 2 e90338

    https://cronfa.swan.ac.uk/Record/cronfa17428 doi: 10.1371/journal.pone.0090338

    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338
18. Turner, M., Cronin, J., Healey, G., Sheldon, I., Sheldon, M. 2014 Epithelial and Stromal Cells of Bovine Endometrium Have Roles in Innate Immunity and Initiate Inflammatory Responses to Bacterial Lipopeptides In Vitro via Toll-Like Receptors TLR2, TLR1, and TLR6 Endocrinology 155 4 1453 1465

    https://cronfa.swan.ac.uk/Record/cronfa17657 doi: 10.1210/en.2013-1822

    http://press.endocrine.org/doi/pdf/10.1210/en.2013-1822
19. Amos, M., Healey, G., Goldstone, R., Mahan, S., Düvel, A., Schuberth, H., Sandra, O., Zieger, P., Dieuzy-Labaye, I., Smith, D., Sheldon, I., Sheldon, M. 2014 Differential Endometrial Cell Sensitivity to a Cholesterol-Dependent Cytolysin Links Trueperella pyogenes to Uterine Disease in Cattle1 Biology of Reproduction 90 3

    https://cronfa.swan.ac.uk/Record/cronfa17658 doi: 10.1095/biolreprod.113.115972
20. Sheldon, I., Cronin, J., Healey, G., Gabler, C., Heuwieser, W., Streyl, D., Bromfield, J., Miyamoto, A., Fergani, C., Dobson, H., Cronin, J., Healey, G., Sheldon, M. 2014 Innate immunity and inflammation of the bovine female reproductive tract in health and disease Reproduction 148 3 R41 R51

    https://cronfa.swan.ac.uk/Record/cronfa18387 doi: 10.1530/REP-14-0163
21. Saut, J., Healey, G., Borges, A., Sheldon, I., Healey, G., Sheldon, M. 2014 Ovarian steroids do not affect bovine endometrial cytokine or chemokine responses to Escherichia coli or LPS in vitro Reproduction 148 6 593 606

    https://cronfa.swan.ac.uk/Record/cronfa19256 doi: 10.1530/REP-14-0230
22. Healey, G., Collier, C., Griffin, S., Schuberth, H., Sandra, O., Smith, D., Mahan, S., Dieuzy-Labaye, I., Sheldon, M. 2016 Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis The Journal of Immunology 196 2 823 831

    https://cronfa.swan.ac.uk/Record/cronfa25016 doi: 10.4049/jimmunol.1501080
23. Healey, G., Conlan, S., Conlan, S. 2017 Nanoscience and Nanotechnology for Human Health (Ed.), Nanoscience and Nanotechnology for Human Health 359 374 Wiley

    https://cronfa.swan.ac.uk/Record/cronfa31652

    http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527338608.html
24. Lesage-Padilla, A., Forde, N., Poirée, M., Healey, G., Giraud-Delville, C., Reinaud, P., Eozenou, C., Carvalho, A., Galio, L., Raliou, M., Oudin, J., Richard, C., Sheldon, I., Charpigny, G., Lonergan, P., Sandra, O., Sheldon, M. 2017 Maternal metabolism affects endometrial expression of oxidative stress and FOXL2 genes in cattle PLOS ONE 12 12 e0189942

    https://cronfa.swan.ac.uk/Record/cronfa37796 doi: 10.1371/journal.pone.0189942
25. Griffin, S., Healey, G., Sheldon, I., Sheldon, M. 2018 Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes† Biology of Reproduction 99 4 749 760

    https://cronfa.swan.ac.uk/Record/cronfa39610 doi: 10.1093/biolre/ioy099
26. Healey, G., Frostell, A., Fagge, T., Gonzalez, D., Conlan, R., Conlan, S. 2019 A RAGE-Targeted Antibody-Drug Conjugate: Surface Plasmon Resonance as a Platform for Accelerating Effective ADC Design and Development Antibodies 8 1 7

    https://cronfa.swan.ac.uk/Record/cronfa48095 doi: 10.3390/antib8010007
27. Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, I., Paolino, D., Fresta, M., Conlan, R., Healey, G., Conlan, S., Sheldon, M. 2019 Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract Biomedical Microdevices 21 2

    https://cronfa.swan.ac.uk/Record/cronfa49813 doi: 10.1007/s10544-019-0385-x
28. Carvalho, A., Eozenou, C., Richard, C., Forde, N., Healey, G., Giraud-Delville, C., Mansouri-Attia, N., Lonergan, P., Sheldon, I., Sandra, O., Healey, G., Sheldon, M. 2019 Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy Reproduction, Fertility and Development

    https://cronfa.swan.ac.uk/Record/cronfa49879 doi: 10.1071/RD18411
29. Healey, G., Pan Castillo, B., Garcia Parra, J., Davies, J., Roberts, S., Jones, E., Dhar, K., Nandanan, S., Tofazzal, N., Piggott, L., Clarkson, R., Seaton, G., Frostell, A., Fagge, T., McKee, C., Margarit, L., Conlan, S., Gonzalez, D. 2019 Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer Journal for ImmunoTherapy of Cancer 7 1

    https://cronfa.swan.ac.uk/Record/cronfa52619 doi: 10.1186/s40425-019-0765-z
30. Eozenou, C., Lesage-Padilla, A., Mauffré, V., Healey, G., Camous, S., Bolifraud, P., Giraud-Delville, C., Vaiman, D., Shimizu, T., Miyamoto, A., Sheldon, M., Constant, F., Pannetier, M., Sandra, O. 2020 FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants International Journal of Molecular Sciences 21 4 1478

    https://cronfa.swan.ac.uk/Record/cronfa53643 doi: 10.3390/ijms21041478

All Research

• PM-304 Biomolecular Research Project

  *

• PM-344 Capstone Project

  The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

• PMNM04 Nanomedicines and Therapeutics

  The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

• PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

  This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

• Celtic Advanced Life Science Innovation Network (CALIN) 2016 - 2023

  , €19M

• Medical Research Council - Confidence in Concept 2020

  , £149K

• Senior Lecturer, Swansea University Medical School

  2019 - Present

• Project Manager – Celtic Advanced Life Science Innovation Networ, Swansea University Medical School

  2016 - Present

• Senior Research Officer – Reproductive Biology and Gynaecologica, Swansea University Medical School

  2014 - Present

• BBSRC Postdoctoral Research Scientist – Centre for Reproductive , Swansea University Medical School

  2011 - Present

• Senior Scientist – Allerna Therapeutics Ltd. , Swansea University Medical School

  2008 - Present

• Research Associate – Experimental Medicine Unit , Swansea University Medical School

  2007 - Present

• Research Scientist , Defence Science and Technology Laboratory (Dstl)

  2001 - Present