Professor Martin Sheldon

Professor in Reproductive Immunobiology, Biomedical Sciences

i.m.sheldon@swansea.ac.uk

Basic Welsh Speaker

Academic Office - 429
Fourth Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0001-7902-5558

ResearchGate

About

Professor Martin Sheldon qualified as a veterinary surgeon in 1984 and worked in clinical practice for 14 years. Whilst in practice, Professor Sheldon was awarded Diplomas for work on health and fertility.

Professor Sheldon moved to the Royal Veterinary College in London in 1998, where he taught veterinary reproduction and established his interests in infection and immunity. During that time he was also awarded his PhD from the University of Liverpool, supervised by Professor Hilary Dobson.

Professor Sheldon was awarded a BBSRC Research Development Fellowship in 2006 to explore the interactions amongst infections, immunity and reproduction. In 2008, Professor Sheldon was appointed to a Personal Chair in Reproductive Immunibiology at Swansea University Medical School.

Areas Of Expertise

Reproductive Biology
Host-Pathogen Interactions
Innate Immunity
Pore-forming Toxins
Tolerance to Pathogens

Career Highlights

Teaching Interests

Reproductive Biology

Host-Pathogen Interactions

Postgraduate Training

Research Award Highlights

Publications

Research Highlights

ORMSBY, T., Owens, S., Turner, M., Cronin, J., Bromfield, J., & Sheldon, M. (2023). Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria. Communications Biology, 6(1), 1-15.
https://doi.org/10.1038/s42003-023-04568-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62675
Ormsby, T., Owens, S., Clement, L., Mills, T., Cronin, J., Bromfield, J., & Sheldon, M. (2022). Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins. Frontiers in Immunology, 13(815775), 815775
https://doi.org/10.3389/fimmu.2022.815775, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59255
Horlock, A., Ormsby, T., Clift, M., Santos, J., Bromfield, J., & Sheldon, M. (2022). Cholesterol supports bovine granulosa cell inflammatory responses to lipopolysaccharide. Reproduction, 164(3), 109-123.
https://doi.org/10.1530/rep-22-0032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60680
Horlock, A., Ormsby, T., Owens, S., Horlock, A., Davies, D., Griffiths, W., Wang, Y., Cronin, J., Bromfield, J., & Sheldon, M. (2021). Oxysterols protect bovine endometrial cells against pore‐forming toxins from pathogenic bacteria. The FASEB Journal, 35(10), 1-21.
https://doi.org/10.1096/fj.202100036r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57632
Pospiech, M., Owens, S., Miller, D., Austin-Muttitt, K., Mullins, J., Cronin, J., Allemann, R., & Sheldon, M. (2021). Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol‐dependent cytolysins. The FASEB Journal, 35(6), 1-19.
https://doi.org/10.1096/fj.202100164r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56884
Horlock, A., Horlock, A., Ormsby, T., Clift, M., Santos, J., Bromfield, J., & Sheldon, M. (2021). Manipulating bovine granulosa cell energy metabolism limits inflammation. Reproduction, 161(5), 499-512.
https://doi.org/10.1530/rep-20-0554, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56383
Sheldon, I., Cronin, J., Bromfield, J., & Sheldon, M. (2019). Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle. Annual Review of Animal Biosciences, 7, 361-384.
https://doi.org/10.1146/annurev-animal-020518-115227, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45241
Dickson, M., Sheldon, M., & Bromfield, J. (2022). Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells. CABI Agriculture and Bioscience, 3(1), 1-15.
https://doi.org/10.1186/s43170-022-00133-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61648
Molinari, P., Dahl, G., Sheldon, M., & Bromfield, J. (2022). Effect of calving season on metritis incidence and bacterial content of the vagina in dairy cows. Theriogenology, 191, 67-76.
https://doi.org/10.1016/j.theriogenology.2022.08.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60851
Abdullaeva, M., Bromfield, J., & Sheldon, M. (2022). Expansion of information in scientific research papers. BioRxiv
https://doi.org/10.1101/2022.05.06.490896, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59996
Molinari, P., Davidson, B., Laporta, J., Dahl, G., Sheldon, M., & Bromfield, J. (2023). Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows. Journal of Dairy Science, 106(2), 1464-1474.
https://doi.org/10.3168/jds.2022-22405, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63601
http://dx.doi.org/10.3168/jds.2022-22405
Dickson, M., Bishop, J., Hansen, T., Sheldon, M., & Bromfield, J. (2022). The endometrial transcriptomic response to pregnancy is altered in cows after uterine infection. PLOS ONE, 17(3), e0265062
https://doi.org/10.1371/journal.pone.0265062, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59755
Husnain, A., Arshad, U., Poindexter, M., Zimpel, R., Marinho, M., Perdomo, M., Fan, P., Jeong, K., Nelson, C., Sheldon, M., Bromfield, J., & Santos, J. (2023). Induced endometritis in early lactation compromises production and reproduction in dairy cows. Journal of Dairy Science, 106(6), 4198-4213.
https://doi.org/10.3168/jds.2022-22846, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63600
http://dx.doi.org/10.3168/jds.2022-22846
Britt, J., Cushman, R., Dechow, C., Dobson, H., Humblot, P., Hutjens, M., Jones, G., Mitloehner, F., Ruegg, P., Sheldon, M., & Stevenson, J. (2021). Review: Perspective on high-performing dairy cows and herds. Animal, 15(Supplement 1), 100298
https://doi.org/10.1016/j.animal.2021.100298, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57314
Chaney, H., Grose, L., Charpigny, G., Behura, S., Sheldon, M., Cronin, J., Lonergan, P., Spencer, T., & Mathew, D. (2021). Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†. Biology of Reproduction, 104(3), 669-683.
https://doi.org/10.1093/biolre/ioaa226, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55920
Piersanti, R., Block, J., Ma, Z., Jeong, K., Santos, J., Yu, F., Sheldon, M., & Bromfield, J. (2020). Uterine infusion of bacteria alters the transcriptome of bovine oocytes. FASEB BioAdvances, 2(8), 506-520.
https://doi.org/10.1096/fba.2020-00029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54685
Horlock, A., Horlock, A., Piersanti, R., Ramirez-Hernandez, R., Yu, F., Ma, Z., Jeong, K., Clift, M., Block, J., Santos, J., Bromfield, J., & Sheldon, M. (2020). Uterine infection alters the transcriptome of the bovine reproductive tract three months later. Reproduction, 160(1), 93-107.
https://doi.org/10.1530/rep-19-0564, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54263
Sheldon, M., Molinari, P., Ormsby, T., & Bromfield, J. (2020). Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria. Theriogenology, 150, 158-165.
https://doi.org/10.1016/j.theriogenology.2020.01.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53247
http://dx.doi.org/10.1016/j.theriogenology.2020.01.017
Turner, M., Owens, S., & Sheldon, M. (2020). Glutamine supports the protection of tissue cells against the damage caused by cholesterol-dependent cytolysins from pathogenic bacteria. PLOS ONE, 15(3), e0219275
https://doi.org/10.1371/journal.pone.0219275, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53816
Eozenou, C., Lesage-Padilla, A., Mauffré, V., Healey, G., Camous, S., Bolifraud, P., Giraud-Delville, C., Vaiman, D., Shimizu, T., Miyamoto, A., Sheldon, M., Constant, F., Pannetier, M., & Sandra, O. (2020). FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants. International Journal of Molecular Sciences, 21(4), 1478
https://doi.org/10.3390/ijms21041478, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53643
Sheldon, M. (2020). Diagnosing postpartum endometritis in dairy cattle. Veterinary Record, 186(3), 88-90.
https://doi.org/10.1136/vr.m222, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53351
Piersanti, R., Santos, J., Sheldon, M., & Bromfield, J. (2019). Lipopolysaccharide and tumor necrosis factor‐alpha alter gene expression of oocytes and cumulus cells during bovine in vitro maturation. Molecular Reproduction and Development, 86(12), 1909-1920.
https://doi.org/10.1002/mrd.23288, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52611
Raliou, M., Dembélé, D., Düvel, A., Bolifraud, P., Aubert, J., Mary-Huard, T., Rocha, D., Piumi, F., Mockly, S., Heppelmann, M., Dieuzy-Labaye, I., Zieger, P., G. E. Smith, D., Schuberth, H., Sheldon, I., Sandra, O., & Sheldon, M. (2019). Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium. PLOS ONE, 14(8), e0220244
https://doi.org/10.1371/journal.pone.0220244, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51324
Horlock, A., Piersanti, R., Horlock, A., Block, J., Santos, J., Sheldon, I., Bromfield, J., & Sheldon, M. (2019). Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease. Reproduction, 158(1), 35-46.
https://doi.org/10.1530/REP-19-0037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49878
Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, M., Paolino, D., Fresta, M., Sawhney, A., & Healey, G. (2019). Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract. Biomedical Microdevices, 21(2)
https://doi.org/10.1007/s10544-019-0385-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49813
Piersanti, R., Zimpel, R., Molinari, P., Dickson, M., Ma, Z., Jeong, K., Santos, J., Sheldon, I., Bromfield, J., & Sheldon, M. (2019). A model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes. Journal of Dairy Science, 102(3), 2686-2697.
https://doi.org/10.3168/jds.2018-15595, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48611
https://www.journalofdairyscience.org/article/S0022-0302(19)30089-X/fulltext
Carvalho, A., Eozenou, C., Richard, C., Forde, N., Healey, G., Giraud-Delville, C., Mansouri-Attia, N., Lonergan, P., Sheldon, I., Sandra, O., Healey, G., & Sheldon, M. (2019). Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy. Reproduction, Fertility and Development
https://doi.org/10.1071/RD18411, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49879
Sheldon, I. & Sheldon, M. (2019). The Metritis Complex in Cattle. Veterinary Reproduction and Obstetrics (pp. 408-433). Elsevier
https://doi.org/10.1016/B978-0-7020-7233-8.00023-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48256
https://www.sciencedirect.com/science/article/pii/B9780702072338000239?via%3Dihub
Griffin, S., Healey, G., Sheldon, I., & Sheldon, M. (2018). Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes†. Biology of Reproduction, 99(4), 749-760.
https://doi.org/10.1093/biolre/ioy099, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39610
Sheldon, M. (2018). Metabolic stress and endometritis in dairy cattle. Veterinary Record, 183(4), 124-125.
https://doi.org/10.1136/vr.k3186, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41142
https://veterinaryrecord.bmj.com/content/183/4/124
Britt, J., Cushman, R., Dechow, C., Dobson, H., Humblot, P., Hutjens, M., Jones, G., Ruegg, P., Sheldon, I., Stevenson, J., & Sheldon, M. (2018). Invited review: Learning from the future—A vision for dairy farms and cows in 2067. Journal of Dairy Science, 101(5), 3722-3741.
https://doi.org/10.3168/jds.2017-14025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39071
Sheldon, I., Cronin, J., Pospiech, M., Turner, M., & Sheldon, M. (2018). Mechanisms linking metabolic stress with innate immunity in the endometrium. Journal of Dairy Science, 101, 3655-3664.
https://doi.org/10.3168/jds.2017-13135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39072
Lesage-Padilla, A., Forde, N., Poirée, M., Healey, G., Giraud-Delville, C., Reinaud, P., Eozenou, C., Carvalho, A., Galio, L., Raliou, M., Oudin, J., Richard, C., Sheldon, I., Charpigny, G., Lonergan, P., Sandra, O., & Sheldon, M. (2017). Maternal metabolism affects endometrial expression of oxidative stress and FOXL2 genes in cattle. PLOS ONE, 12(12), e0189942
https://doi.org/10.1371/journal.pone.0189942, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37796
Griffin, S., Preta, G., Sheldon, I., & Sheldon, M. (2017). Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin. Scientific Reports, 7(1), 1-13.
https://doi.org/10.1038/s41598-017-17138-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37344
Sheldon, I., Sheldon, M., & Owens, S. (2017). Postpartum uterine infection and endometritis in dairy cattle. Animal Reproduction, 14(3), 622-629.
https://doi.org/10.21451/1984-3143-AR1006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35667
Carneiro, L., Bedford, C., Jacca, S., Rosamilia, A., Lima, V., Donofrio, G., Sheldon, I., Cronin, J., & Sheldon, M. (2017). Coordinated Role of Toll-Like Receptor-3 and Retinoic Acid-Inducible Gene-I in the Innate Response of Bovine Endometrial Cells to Virus. Frontiers in Immunology, 8
https://doi.org/10.3389/fimmu.2017.00996, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34992
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00996/full
Gadsby, J., Tyson Nipper, A., Faircloth, H., D'Annibale-Tolhurst, M., Chang, J., Farin, P., Sheldon, I., Poole, D., & Sheldon, M. (2017). Toll-like receptor and related cytokine mRNA expression in bovine corpora lutea during the oestrous cycle and pregnancy. Reproduction in Domestic Animals, 52(3), 495-504.
https://doi.org/10.1111/rda.12940, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32732
Noleto, P., Saut, J., Sheldon, I., & Sheldon, M. (2017). Short communication: Glutamine modulates inflammatory responses to lipopolysaccharide in ex vivo bovine endometrium. Journal of Dairy Science, 100, 2207-2212.
https://doi.org/10.3168/jds.2016-12023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31648
Sheldon, I., Owens, S., Turner, M., & Sheldon, M. (2017). Innate immunity and the sensing of infection, damage and danger in the female genital tract. Journal of Reproductive Immunology, 119, 67-73.
https://doi.org/10.1016/j.jri.2016.07.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29373
Thornton, C., Cronin, J., Kanamarlapudi, V., & Sheldon, M. (2016). Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology, 9(4), 1125-1136.
https://doi.org/10.1038/mi.2015.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25017
http://www.nature.com/mi/journal/vaop/ncurrent/full/mi2015131a.html
Preta, G., Jankunec, M., Heinrich, F., Griffin, S., Sheldon, M., & Valincius, G. (2016). Tethered bilayer membranes as a complementary tool for functional and structural studies: The pyolysin case. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858(9), 2070-2080.
https://doi.org/10.1016/j.bbamem.2016.05.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28288
Sheldon, I. & Sheldon, M. (2016). Detection of Pathogens in Blood for Diagnosis of Sepsis and Beyond. EBioMedicine, 9, 13-14.
https://doi.org/10.1016/j.ebiom.2016.06.030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28995
Turner, M., Cronin, J., Noleto, P., Sheldon, I., & Sheldon, M. (2016). Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium. PLOS ONE, 11(3), e0151416
https://doi.org/10.1371/journal.pone.0151416, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26753
Carneiro, L., Cronin, J., & Sheldon, M. (2016). Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility. Reproductive Biology, 16(1), 1-7.
https://doi.org/10.1016/j.repbio.2015.12.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25302
Healey, G., Collier, C., Griffin, S., Schuberth, H., Sandra, O., Smith, D., Mahan, S., Dieuzy-Labaye, I., & Sheldon, M. (2016). Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. The Journal of Immunology, 196(2), 823-831.
https://doi.org/10.4049/jimmunol.1501080, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25016
Sheldon, I. & Sheldon, M. (2015). Genes and environmental factors that influence disease resistance to microbes in the female reproductive tract of dairy cattle. Reproduction, Fertility and Development, 27(1), 72
https://doi.org/10.1071/RD14305, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19691
MacKintosh, S., Serino, L., Iddon, P., Brown, R., Conlan, R., Wright, C., Maffeis, T., Raxworthy, M., Sheldon, I., Wright, C., Conlan, S., Maffeis, T., & Sheldon, M. (2015). A three-dimensional model of primary bovine endometrium using an electrospun scaffold. Biofabrication, 7(2), 025010
https://doi.org/10.1088/1758-5090/7/2/025010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21884
http://iopscience.iop.org/1758-5090/7/2/025010/
Bromfield, J., Santos, J., Block, J., Williams, R., Sheldon, I., & Sheldon, M. (2015). PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow. Journal of Animal Science, 93(5), 2021-2033.
https://doi.org/10.2527/jas.2014-8496, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20697
Sheldon, I. & Sheldon, M. (2015). Milk somatic cell counts and pregnancy rates in dairy cattle. Veterinary Record, 176(16), 409-410.
https://doi.org/10.1136/vr.h1950, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20775
Preta, G., Cronin, J., Sheldon, I., & Sheldon, M. (2015). Dynasore - not just a dynamin inhibitor. Cell Communication and Signaling, 13(1)
https://doi.org/10.1186/s12964-015-0102-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20642
http://www.biosignaling.com/content/pdf/s12964-015-0102-1.pdf

All Research

Journal Articles

Yasim Farook, M., Croxford, Z., Morgan, S., Horlock, A., Holt, A., Rees, A., Jenkins, B., TSE, C., Stanton, E., Davies, D., Thornton, C., Jones, N., Sheldon, M., Vincent, E., & Cronin, J. (2024). Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer. Molecular Metabolism, 81
https://doi.org/10.1016/j.molmet.2024.101900, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65663
Husnain, A., Arshad, U., Poindexter, M., Zimpel, R., Marinho, M., Perdomo, M., Fan, P., Jeong, K., Nelson, C., Sheldon, M., Bromfield, J., & Santos, J. (2023). Induced endometritis in early lactation compromises production and reproduction in dairy cows. Journal of Dairy Science, 106(6), 4198-4213.
https://doi.org/10.3168/jds.2022-22846, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63600
http://dx.doi.org/10.3168/jds.2022-22846
ORMSBY, T., Owens, S., Turner, M., Cronin, J., Bromfield, J., & Sheldon, M. (2023). Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria. Communications Biology, 6(1), 1-15.
https://doi.org/10.1038/s42003-023-04568-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62675
Molinari, P., Davidson, B., Laporta, J., Dahl, G., Sheldon, M., & Bromfield, J. (2023). Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows. Journal of Dairy Science, 106(2), 1464-1474.
https://doi.org/10.3168/jds.2022-22405, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63601
http://dx.doi.org/10.3168/jds.2022-22405
Dickson, M., Sheldon, M., & Bromfield, J. (2022). Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells. CABI Agriculture and Bioscience, 3(1), 1-15.
https://doi.org/10.1186/s43170-022-00133-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61648
Molinari, P., Dahl, G., Sheldon, M., & Bromfield, J. (2022). Effect of calving season on metritis incidence and bacterial content of the vagina in dairy cows. Theriogenology, 191, 67-76.
https://doi.org/10.1016/j.theriogenology.2022.08.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60851
Horlock, A., Ormsby, T., Clift, M., Santos, J., Bromfield, J., & Sheldon, M. (2022). Cholesterol supports bovine granulosa cell inflammatory responses to lipopolysaccharide. Reproduction, 164(3), 109-123.
https://doi.org/10.1530/rep-22-0032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60680
Abdullaeva, M., Bromfield, J., & Sheldon, M. (2022). Expansion of information in scientific research papers. BioRxiv
https://doi.org/10.1101/2022.05.06.490896, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59996
Dickson, M., Bishop, J., Hansen, T., Sheldon, M., & Bromfield, J. (2022). The endometrial transcriptomic response to pregnancy is altered in cows after uterine infection. PLOS ONE, 17(3), e0265062
https://doi.org/10.1371/journal.pone.0265062, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59755
Ormsby, T., Owens, S., Clement, L., Mills, T., Cronin, J., Bromfield, J., & Sheldon, M. (2022). Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins. Frontiers in Immunology, 13(815775), 815775
https://doi.org/10.3389/fimmu.2022.815775, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59255
Horlock, A., Ormsby, T., Owens, S., Horlock, A., Davies, D., Griffiths, W., Wang, Y., Cronin, J., Bromfield, J., & Sheldon, M. (2021). Oxysterols protect bovine endometrial cells against pore‐forming toxins from pathogenic bacteria. The FASEB Journal, 35(10), 1-21.
https://doi.org/10.1096/fj.202100036r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57632
Britt, J., Cushman, R., Dechow, C., Dobson, H., Humblot, P., Hutjens, M., Jones, G., Mitloehner, F., Ruegg, P., Sheldon, M., & Stevenson, J. (2021). Review: Perspective on high-performing dairy cows and herds. Animal, 15(Supplement 1), 100298
https://doi.org/10.1016/j.animal.2021.100298, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57314
Pospiech, M., Owens, S., Miller, D., Austin-Muttitt, K., Mullins, J., Cronin, J., Allemann, R., & Sheldon, M. (2021). Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol‐dependent cytolysins. The FASEB Journal, 35(6), 1-19.
https://doi.org/10.1096/fj.202100164r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56884
Horlock, A., Horlock, A., Ormsby, T., Clift, M., Santos, J., Bromfield, J., & Sheldon, M. (2021). Manipulating bovine granulosa cell energy metabolism limits inflammation. Reproduction, 161(5), 499-512.
https://doi.org/10.1530/rep-20-0554, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56383
Chaney, H., Grose, L., Charpigny, G., Behura, S., Sheldon, M., Cronin, J., Lonergan, P., Spencer, T., & Mathew, D. (2021). Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†. Biology of Reproduction, 104(3), 669-683.
https://doi.org/10.1093/biolre/ioaa226, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55920
Dickson, M., Piersanti, R., Ramirez-Hernandez, R., Oliveira, E., Bishop, J., Hansen, T., Ma, Z., Jeong, K., Santos, J., Sheldon, M., Block, J., & Bromfield, J. (2020). Experimentally Induced Endometritis Impairs the Developmental Capacity of Bovine Oocytes†. Biology of Reproduction, 103(3), 508-520.
https://doi.org/10.1093/biolre/ioaa069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54269
http://dx.doi.org/10.1093/biolre/ioaa069
Piersanti, R., Block, J., Ma, Z., Jeong, K., Santos, J., Yu, F., Sheldon, M., & Bromfield, J. (2020). Uterine infusion of bacteria alters the transcriptome of bovine oocytes. FASEB BioAdvances, 2(8), 506-520.
https://doi.org/10.1096/fba.2020-00029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54685
Horlock, A., Horlock, A., Piersanti, R., Ramirez-Hernandez, R., Yu, F., Ma, Z., Jeong, K., Clift, M., Block, J., Santos, J., Bromfield, J., & Sheldon, M. (2020). Uterine infection alters the transcriptome of the bovine reproductive tract three months later. Reproduction, 160(1), 93-107.
https://doi.org/10.1530/rep-19-0564, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54263
Sheldon, M., Molinari, P., Ormsby, T., & Bromfield, J. (2020). Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria. Theriogenology, 150, 158-165.
https://doi.org/10.1016/j.theriogenology.2020.01.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53247
http://dx.doi.org/10.1016/j.theriogenology.2020.01.017
Turner, M., Owens, S., & Sheldon, M. (2020). Glutamine supports the protection of tissue cells against the damage caused by cholesterol-dependent cytolysins from pathogenic bacteria. PLOS ONE, 15(3), e0219275
https://doi.org/10.1371/journal.pone.0219275, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53816
Eozenou, C., Lesage-Padilla, A., Mauffré, V., Healey, G., Camous, S., Bolifraud, P., Giraud-Delville, C., Vaiman, D., Shimizu, T., Miyamoto, A., Sheldon, M., Constant, F., Pannetier, M., & Sandra, O. (2020). FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants. International Journal of Molecular Sciences, 21(4), 1478
https://doi.org/10.3390/ijms21041478, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53643
Sheldon, M. (2020). Diagnosing postpartum endometritis in dairy cattle. Veterinary Record, 186(3), 88-90.
https://doi.org/10.1136/vr.m222, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53351
Piersanti, R., Santos, J., Sheldon, M., & Bromfield, J. (2019). Lipopolysaccharide and tumor necrosis factor‐alpha alter gene expression of oocytes and cumulus cells during bovine in vitro maturation. Molecular Reproduction and Development, 86(12), 1909-1920.
https://doi.org/10.1002/mrd.23288, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52611
Raliou, M., Dembélé, D., Düvel, A., Bolifraud, P., Aubert, J., Mary-Huard, T., Rocha, D., Piumi, F., Mockly, S., Heppelmann, M., Dieuzy-Labaye, I., Zieger, P., G. E. Smith, D., Schuberth, H., Sheldon, I., Sandra, O., & Sheldon, M. (2019). Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium. PLOS ONE, 14(8), e0220244
https://doi.org/10.1371/journal.pone.0220244, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51324
Horlock, A., Piersanti, R., Horlock, A., Block, J., Santos, J., Sheldon, I., Bromfield, J., & Sheldon, M. (2019). Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease. Reproduction, 158(1), 35-46.
https://doi.org/10.1530/REP-19-0037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49878
Pisano, S., Giustiniani, M., Francis, L., Gonzalez, D., Margarit, L., Sheldon, M., Paolino, D., Fresta, M., Sawhney, A., & Healey, G. (2019). Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract. Biomedical Microdevices, 21(2)
https://doi.org/10.1007/s10544-019-0385-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49813
Piersanti, R., Zimpel, R., Molinari, P., Dickson, M., Ma, Z., Jeong, K., Santos, J., Sheldon, I., Bromfield, J., & Sheldon, M. (2019). A model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes. Journal of Dairy Science, 102(3), 2686-2697.
https://doi.org/10.3168/jds.2018-15595, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48611
https://www.journalofdairyscience.org/article/S0022-0302(19)30089-X/fulltext
Carvalho, A., Eozenou, C., Richard, C., Forde, N., Healey, G., Giraud-Delville, C., Mansouri-Attia, N., Lonergan, P., Sheldon, I., Sandra, O., Healey, G., & Sheldon, M. (2019). Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy. Reproduction, Fertility and Development
https://doi.org/10.1071/RD18411, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49879
Sheldon, I., Cronin, J., Bromfield, J., & Sheldon, M. (2019). Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle. Annual Review of Animal Biosciences, 7, 361-384.
https://doi.org/10.1146/annurev-animal-020518-115227, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45241
Griffin, S., Healey, G., Sheldon, I., & Sheldon, M. (2018). Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes†. Biology of Reproduction, 99(4), 749-760.
https://doi.org/10.1093/biolre/ioy099, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39610
Sheldon, M. (2018). Metabolic stress and endometritis in dairy cattle. Veterinary Record, 183(4), 124-125.
https://doi.org/10.1136/vr.k3186, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41142
https://veterinaryrecord.bmj.com/content/183/4/124
Britt, J., Cushman, R., Dechow, C., Dobson, H., Humblot, P., Hutjens, M., Jones, G., Ruegg, P., Sheldon, I., Stevenson, J., & Sheldon, M. (2018). Invited review: Learning from the future—A vision for dairy farms and cows in 2067. Journal of Dairy Science, 101(5), 3722-3741.
https://doi.org/10.3168/jds.2017-14025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39071
Sheldon, I., Cronin, J., Pospiech, M., Turner, M., & Sheldon, M. (2018). Mechanisms linking metabolic stress with innate immunity in the endometrium. Journal of Dairy Science, 101, 3655-3664.
https://doi.org/10.3168/jds.2017-13135, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39072
Lesage-Padilla, A., Forde, N., Poirée, M., Healey, G., Giraud-Delville, C., Reinaud, P., Eozenou, C., Carvalho, A., Galio, L., Raliou, M., Oudin, J., Richard, C., Sheldon, I., Charpigny, G., Lonergan, P., Sandra, O., & Sheldon, M. (2017). Maternal metabolism affects endometrial expression of oxidative stress and FOXL2 genes in cattle. PLOS ONE, 12(12), e0189942
https://doi.org/10.1371/journal.pone.0189942, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37796
Griffin, S., Preta, G., Sheldon, I., & Sheldon, M. (2017). Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin. Scientific Reports, 7(1), 1-13.
https://doi.org/10.1038/s41598-017-17138-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37344
Sheldon, I., Sheldon, M., & Owens, S. (2017). Postpartum uterine infection and endometritis in dairy cattle. Animal Reproduction, 14(3), 622-629.
https://doi.org/10.21451/1984-3143-AR1006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35667
Carneiro, L., Bedford, C., Jacca, S., Rosamilia, A., Lima, V., Donofrio, G., Sheldon, I., Cronin, J., & Sheldon, M. (2017). Coordinated Role of Toll-Like Receptor-3 and Retinoic Acid-Inducible Gene-I in the Innate Response of Bovine Endometrial Cells to Virus. Frontiers in Immunology, 8
https://doi.org/10.3389/fimmu.2017.00996, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34992
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00996/full
Gadsby, J., Tyson Nipper, A., Faircloth, H., D'Annibale-Tolhurst, M., Chang, J., Farin, P., Sheldon, I., Poole, D., & Sheldon, M. (2017). Toll-like receptor and related cytokine mRNA expression in bovine corpora lutea during the oestrous cycle and pregnancy. Reproduction in Domestic Animals, 52(3), 495-504.
https://doi.org/10.1111/rda.12940, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32732
Noleto, P., Saut, J., Sheldon, I., & Sheldon, M. (2017). Short communication: Glutamine modulates inflammatory responses to lipopolysaccharide in ex vivo bovine endometrium. Journal of Dairy Science, 100, 2207-2212.
https://doi.org/10.3168/jds.2016-12023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31648
Sheldon, I., Owens, S., Turner, M., & Sheldon, M. (2017). Innate immunity and the sensing of infection, damage and danger in the female genital tract. Journal of Reproductive Immunology, 119, 67-73.
https://doi.org/10.1016/j.jri.2016.07.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29373
Thornton, C., Cronin, J., Kanamarlapudi, V., & Sheldon, M. (2016). Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology, 9(4), 1125-1136.
https://doi.org/10.1038/mi.2015.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25017
http://www.nature.com/mi/journal/vaop/ncurrent/full/mi2015131a.html
Preta, G., Jankunec, M., Heinrich, F., Griffin, S., Sheldon, M., & Valincius, G. (2016). Tethered bilayer membranes as a complementary tool for functional and structural studies: The pyolysin case. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858(9), 2070-2080.
https://doi.org/10.1016/j.bbamem.2016.05.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28288
Sheldon, I. & Sheldon, M. (2016). Detection of Pathogens in Blood for Diagnosis of Sepsis and Beyond. EBioMedicine, 9, 13-14.
https://doi.org/10.1016/j.ebiom.2016.06.030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa28995
Turner, M., Cronin, J., Noleto, P., Sheldon, I., & Sheldon, M. (2016). Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium. PLOS ONE, 11(3), e0151416
https://doi.org/10.1371/journal.pone.0151416, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26753
Carneiro, L., Cronin, J., & Sheldon, M. (2016). Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility. Reproductive Biology, 16(1), 1-7.
https://doi.org/10.1016/j.repbio.2015.12.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25302
Healey, G., Collier, C., Griffin, S., Schuberth, H., Sandra, O., Smith, D., Mahan, S., Dieuzy-Labaye, I., & Sheldon, M. (2016). Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. The Journal of Immunology, 196(2), 823-831.
https://doi.org/10.4049/jimmunol.1501080, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25016
Sheldon, I. & Sheldon, M. (2015). Genes and environmental factors that influence disease resistance to microbes in the female reproductive tract of dairy cattle. Reproduction, Fertility and Development, 27(1), 72
https://doi.org/10.1071/RD14305, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19691
MacKintosh, S., Serino, L., Iddon, P., Brown, R., Conlan, R., Wright, C., Maffeis, T., Raxworthy, M., Sheldon, I., Wright, C., Conlan, S., Maffeis, T., & Sheldon, M. (2015). A three-dimensional model of primary bovine endometrium using an electrospun scaffold. Biofabrication, 7(2), 025010
https://doi.org/10.1088/1758-5090/7/2/025010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21884
http://iopscience.iop.org/1758-5090/7/2/025010/
Bromfield, J., Santos, J., Block, J., Williams, R., Sheldon, I., & Sheldon, M. (2015). PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow. Journal of Animal Science, 93(5), 2021-2033.
https://doi.org/10.2527/jas.2014-8496, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20697
Sheldon, I. & Sheldon, M. (2015). Milk somatic cell counts and pregnancy rates in dairy cattle. Veterinary Record, 176(16), 409-410.
https://doi.org/10.1136/vr.h1950, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20775
Preta, G., Cronin, J., Sheldon, I., & Sheldon, M. (2015). Dynasore - not just a dynamin inhibitor. Cell Communication and Signaling, 13(1)
https://doi.org/10.1186/s12964-015-0102-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20642
http://www.biosignaling.com/content/pdf/s12964-015-0102-1.pdf
Preta, G., Lotti, V., Cronin, J., Sheldon, I., Cronin, J., & Sheldon, M. (2015). Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. The FASEB Journal, 29(4), 1516-1528.
https://doi.org/10.1096/fj.14-265207, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19859
http://www.fasebj.org/content/29/4/1516.full
Vitorino Carvalho, A., Reinaud, P., Forde, N., Healey, G., Eozenou, C., Giraud-delville, C., Mansouri-Attia, N., Gall, L., Richard, C., Lonergan, P., Sheldon, I., Lea, R., Sandra, O., Healey, G., & Sheldon, M. (2014). SOCS genes expression during physiological and perturbed implantation in bovine endometrium. Reproduction
https://doi.org/10.1530/rep-14-0214, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18919
Vitorino Carvalho, A., Eozenou, C., Healey, G., Forde, N., Reinaud, P., Chebrout, M., Gall, L., Rodde, N., Padilla, A., Delville, C., Leveugle, M., Richard, C., Sheldon, I., Lonergan, P., Jolivet, G., Sandra, O., Healey, G., & Sheldon, M. (2014). Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium. Reproduction, Fertility and Development
https://doi.org/10.1071/rd14034, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18917
Sheldon, I., Cronin, J., Healey, G., Gabler, C., Heuwieser, W., Streyl, D., Bromfield, J., Miyamoto, A., Fergani, C., Dobson, H., Cronin, J., Healey, G., & Sheldon, M. (2014). Innate immunity and inflammation of the bovine female reproductive tract in health and disease. Reproduction, 148(3), R41-R51.
https://doi.org/10.1530/REP-14-0163, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18387
Goldstone, R., Popat, R., Schuberth, H., Sandra, O., Sheldon, I., Smith, D., & Sheldon, M. (2014). Genomic characterisation of an endometrial pathogenic Escherichia coli strain reveals the acquisition of genetic elements associated with extra-intestinal pathogenicity. BMC Genomics, 15(1), 1075
https://doi.org/10.1186/1471-2164-15-1075, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20050
Cronin, J., Hodges, R., Pedersen, S., Sheldon, I., & Sheldon, M. (2014). Enzyme Linked Immunosorbent Assay for Quantification of Bovine Interleukin-8 to Study Infection and Immunity in the Female Genital Tract. American Journal of Reproductive Immunology, n/a-n/a.
https://doi.org/10.1111/aji.12344, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19649
Saut, J., Healey, G., Borges, A., Sheldon, I., Healey, G., & Sheldon, M. (2014). Ovarian steroids do not affect bovine endometrial cytokine or chemokine responses to Escherichia coli or LPS in vitro. Reproduction, 148(6), 593-606.
https://doi.org/10.1530/REP-14-0230, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19256
Healy, L., Cronin, J., Sheldon, I., & Sheldon, M. (2014). Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1. Scientific Reports, 4, 7060
https://doi.org/10.1038/srep07060, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19258
Goldstone, R., Talbot, R., Schuberth, H., Sandra, O., Sheldon, I., Smith, D., & Sheldon, M. (2014). Draft Genome Sequence of Escherichia coli MS499, Isolated from the Infected Uterus of a Postpartum Cow with Metritis. Genome Announcements, 2(4), e00217-14-e00217-14.
https://doi.org/10.1128/genomeA.00217-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18106
http://genomea.asm.org/content/2/4/e00217-14.abstract
Goldstone, R., Amos, M., Talbot, R., Schuberth, H., Sandra, O., Sheldon, I., Smith, D., & Sheldon, M. (2014). Draft Genome Sequence of Trueperella pyogenes, Isolated from the Infected Uterus of a Postpartum Cow with Metritis. Genome Announcements, 2(2), e00194-14-e00194-14.
https://doi.org/10.1128/genomeA.00194-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18025
http://genomea.asm.org/content/2/2/e00194-14.full.pdf+html
Turner, M., Cronin, J., Healey, G., Sheldon, I., & Sheldon, M. (2014). Epithelial and Stromal Cells of Bovine Endometrium Have Roles in Innate Immunity and Initiate Inflammatory Responses to Bacterial Lipopeptides In Vitro via Toll-Like Receptors TLR2, TLR1, and TLR6. Endocrinology, 155(4), 1453-1465.
https://doi.org/10.1210/en.2013-1822, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17657
http://press.endocrine.org/doi/pdf/10.1210/en.2013-1822
Düvel, A., Maaß, J., Heppelmann, M., Hussen, J., Koy, M., Piechotta, M., Sandra, O., Smith, D., Sheldon, I., Dieuzy-Labaye, I., Zieger, P., Schuberth, H., & Sheldon, M. (2014). Peripheral blood leukocytes of cows with subclinical endometritis show an altered cellular composition and gene expression. Theriogenology, 81(7), 906-917.
https://doi.org/10.1016/j.theriogenology.2014.01.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17659
Amos, M., Healey, G., Goldstone, R., Mahan, S., Düvel, A., Schuberth, H., Sandra, O., Zieger, P., Dieuzy-Labaye, I., Smith, D., Sheldon, I., & Sheldon, M. (2014). Differential Endometrial Cell Sensitivity to a Cholesterol-Dependent Cytolysin Links Trueperella pyogenes to Uterine Disease in Cattle1. Biology of Reproduction, 90(3)
https://doi.org/10.1095/biolreprod.113.115972, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17658
Johnson, A., Beynon, A., Brown, M., Wright, R., Rees, M., Sheldon, I., Davies, J., Brown, R., & Sheldon, M. (2013). Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones. Journal of Neuroinflammation, 10(1), 40
https://doi.org/10.1186/1742-2094-10-40, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14452
Price, J., Sheldon, I., & Sheldon, M. (2013). Granulosa Cells from Emerged Antral Follicles of the Bovine Ovary Initiate Inflammation in Response to Bacterial Pathogen-Associated Molecular Patterns via Toll-Like Receptor Pathways. Biology of Reproduction, 89(5), 119-119.
https://doi.org/10.1095/biolreprod.113.110965, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16918
http://www.biolreprod.org/content/89/5/119.abstract
Hussen, J., Düvel, A., Sandra, O., Smith, D., Sheldon, I., Zieger, P., Schuberth, H., & Sheldon, M. (2013). Phenotypic and Functional Heterogeneity of Bovine Blood Monocytes. PLoS ONE, 8(8), e71502
https://doi.org/10.1371/journal.pone.0071502, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16920
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0071502
Price, J., Bromfield, J., Sheldon, I., & Sheldon, M. (2013). Pathogen-Associated Molecular Patterns Initiate Inflammation and Perturb the Endocrine Function of Bovine Granulosa Cells From Ovarian Dominant Follicles via TLR2 and TLR4 Pathways. Endocrinology, 154(9), 3377-3386.
https://doi.org/10.1210/en.2013-1102, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15414
http://endo.endojournals.org/content/early/2013/07/02/en.2013-1102.abstract
Jacca, S., Franceschi, V., Colagiorgi, A., Sheldon, M., Donofrio, G., & Sheldon, M. (2013). Bovine Endometrial Stromal Cells Support Tumor Necrosis Factor Alpha-Induced Bovine Herpesvirus Type 4 Enhanced Replication. Biology of Reproduction, 88(5), 135-135.
https://doi.org/10.1095/biolreprod.112.106740, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16919
Bromfield, J., Sheldon, I., & Sheldon, M. (2013). Lipopolysaccharide Reduces the Primordial Follicle Pool in the Bovine Ovarian Cortex Ex Vivo and in the Murine Ovary In Vivo1. Biology of Reproduction, 88(4)
https://doi.org/10.1095/biolreprod.112.106914, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15413
http://www.biolreprod.org/content/88/4/98.long
MacKintosh, S., Schuberth, H., Healy, L., Sheldon, I., Sheldon, M., & Healy, L. (2013). Polarised bovine endometrial epithelial cells vectorially secrete prostaglandins and chemotactic factors under physiological and pathological conditions. Reproduction, 145(1), 57-72.
https://doi.org/10.1530/REP-12-0253, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13925
http://www.reproduction-online.org/content/145/1/57.abstract
Borges, Á., Healey, G., Sheldon, I., & Sheldon, M. (2012). Explants of Intact Endometrium to Model Bovine Innate Immunity and Inflammation Ex Vivo. American Journal of Reproductive Immunology, 67(6), 526-539.
https://doi.org/10.1111/j.1600-0897.2012.01106.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11549
Price, J., Cronin, J., Sheldon, I., & Sheldon, M. (2012). Toll-Like Receptor Expression and Function in the COV434 Granulosa Cell Line. American Journal of Reproductive Immunology, n/a-n/a.
https://doi.org/10.1111/j.1600-0897.2011.01103.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11550
Cronin, J., Turner, M., Goetze, L., Bryant, C., Sheldon, I., Cronin, J., Sheldon, M., & Turner, M. (2012). Toll-Like Receptor 4 and MYD88-Dependent Signaling Mechanisms of the Innate Immune System Are Essential for the Response to Lipopolysaccharide by Epithelial and Stromal Cells of the Bovine Endometrium. Biology of Reproduction, 86(2), 51-51.
https://doi.org/10.1095/biolreprod.111.092718, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11551
Turner, M., Healey, G., Sheldon, I., Healey, G., Sheldon, M., & Turner, M. (2012). Immunity and Inflammation in the Uterus. Reproduction in Domestic Animals, 47, 402-409.
https://doi.org/10.1111/j.1439-0531.2012.02104.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13924
Sheldon, I. & Sheldon, M. (2011). Innate immunity in the human endometrium and ovary. AJRI
https://doi.org/10.1111/j.1600-0897.2011.01005.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11552
Bromfield, J., Sheldon, I., Sheldon, M., & Bromfield, J. (2011). Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro. Endocrinology, 152(12), 5029-5040.
https://doi.org/10.1210/en.2011-1124, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10278
Donofrio, G., Capocefalo, A., Franceschi, V., Price, S., Cavirani, S., Sheldon, I., & Sheldon, M. (2010). The Chemokine IL8 Is Up-Regulated in Bovine Endometrial Stromal Cells by the BoHV-4 IE2 Gene Product, ORF50/Rta: A Step Ahead Toward a Mechanism for BoHV-4 Induced Endometritis. Biology of Reproduction, 83(6), 919-928.
https://doi.org/10.1095/biolreprod.110.086074, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9261
Nash, D., Sheldon, I., Herath, S., Lane, E., & Sheldon, M. (2010). Markers of the uterine innate immune response of the mare. Animal Reproduction Science, 119(1-2), 31-39.
https://doi.org/10.1016/j.anireprosci.2009.11.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9262
Sheldon, I., Roberts, M., & Sheldon, M. (2010). Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium.. PLoS One, 5, e12906
https://doi.org/10.1371/journal.pone.0012906, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9968
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012906
Sturtevant, J., Sheldon, I., Rycroft, A., Dogan, B., Craven, M., Bromfield, J., Chandler, A., Roberts, M., Price, S., Gilbert, R., Simpson, K., & Sheldon, M. (2010). Specific Strains of Escherichia coli Are Pathogenic for the Endometrium of Cattle and Cause Pelvic Inflammatory Disease in Cattle and Mice. PLoS ONE, 5(2), e9192
https://doi.org/10.1371/journal.pone.0009192, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10054
Nash, D., Sheldon, I., Herath, S., Lane, E., & Sheldon, M. (2010). Endometrial Explant Culture to Study the Response of Equine Endometrium to Insemination. Reproduction in Domestic Animals
https://doi.org/10.1111/j.1439-0531.2008.01328.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19519
Herath, S., Lilly, S., Fischer, D., Williams, E., Dobson, H., Bryant, C., Sheldon, I., & Sheldon, M. (2009). Bacterial Lipopolysaccharide Induces an Endocrine Switch from Prostaglandin F2 to Prostaglandin E2 in Bovine Endometrium. Endocrinology, 150(4), 1912-1920.
https://doi.org/10.1210/en.2008-1379, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9970
Sheldon, I., Cronin, J., Goetze, L., Donofrio, G., Schuberth, H., & Sheldon, M. (2009). Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle. Biology of Reproduction, 81(6), 1025-1032.
https://doi.org/10.1095/biolreprod.109.077370, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13006
Sheldon, I., Cronin, J., Goetze, L., Donofrio, G., Schuberth, H., Cronin, J., & Sheldon, M. (2009). Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle. Biology of Reproduction, 81(6), 1025-1032.
https://doi.org/10.1095/biolreprod.109.077370, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12979
Sheldon, I., Price, S., Cronin, J., Gilbert, R., Gadsby, J., Cronin, J., & Sheldon, M. (2009). Mechanisms of Infertility Associated with Clinical and Subclinical Endometritis in High Producing Dairy Cattle. Reproduction in Domestic Animals, 44, 1-9.
https://doi.org/10.1111/j.1439-0531.2009.01465.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12977
Donofrio, G., Franceschi, V., Capocefalo, A., Cavirani, S., Sheldon, I., & Sheldon, M. (2009). Isolation and characterization of bovine herpesvirus 4 (BoHV-4) from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosome. Reproductive Biology and Endocrinology, 7(1), 83
https://doi.org/10.1186/1477-7827-7-83, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19514
Herath, S., Lilly, S., Santos, N., Gilbert, R., Goetze, L., Bryant, C., White, J., Cronin, J., Sheldon, I., & Sheldon, M. (2009). Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. Reproductive Biology and Endocrinology, 7(1), 55
https://doi.org/10.1186/1477-7827-7-55, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12978
Channon, A., Walker, A., Pfau, T., Sheldon, I., Wilson, A., & Sheldon, M. (2009). Variability of Manson and Leaver locomotion scores assigned to dairy cows by different observers. Veterinary Record, 164(13), 388-392.
https://doi.org/10.1136/vr.164.13.388, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43612
Donofrio, G., Ravanetti, L., Cavirani, S., Herath, S., Capocefalo, A., Sheldon, I., & Sheldon, M. (2008). Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease. Reproduction, 136(3), 361-366.
https://doi.org/10.1530/REP-08-0171, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11553
Murray, R., Williams, A., Sheldon, I., & Sheldon, M. (2008). Field Investigation of Perinatal Mortality in Friesian Cattle Associated with Myocardial Degeneration and Necrosis. Reproduction in Domestic Animals, 43(3), 339-345.
https://doi.org/10.1111/j.1439-0531.2007.00911.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43613
Davies, D., Meade, K., Herath, S., Eckersall, P., Gonzalez, D., White, J., Conlan, R., O'Farrelly, C., Sheldon, I., Conlan, S., & Sheldon, M. (2008). Toll-like receptor and antimicrobial peptide expression in the bovine endometrium. Reproductive Biology and Endocrinology, 6(1), 53
https://doi.org/10.1186/1477-7827-6-53, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10492
Donofrio, G., Franceschi, V., Capocefalo, A., Cavirani, S., Sheldon, I., & Sheldon, M. (2008). Bovine endometrial stromal cells display osteogenic properties. Reproductive Biology and Endocrinology, 6(1), 65
https://doi.org/10.1186/1477-7827-6-65, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19520
Williams, E., Sibley, K., Miller, A., Lane, E., Fishwick, J., Nash, D., Herath, S., England, G., Dobson, H., Sheldon, I., & Sheldon, M. (2008). ORIGINAL ARTICLE: The Effect of Escherichia coli Lipopolysaccharide and Tumour Necrosis Factor Alpha on Ovarian Function. American Journal of Reproductive Immunology, 60(5), 462-473.
https://doi.org/10.1111/j.1600-0897.2008.00645.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19518
Donofrio, G., Ravanetti, L., Cavirani, S., Herath, S., Capocefalo, A., Sheldon, I., & Sheldon, M. (2008). Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease. Reproduction, 136(3), 361-366.
https://doi.org/10.1530/REP-08-0171, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19523
Williams, E., Herath, S., England, G., Dobson, H., Bryant, C., Sheldon, I., & Sheldon, M. (2008). Effect of Escherichia coli infection of the bovine uterus from the whole animal to the cell. animal, 2(08)
https://doi.org/10.1017/S1751731108002413, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19522
Cripps, R., Green, L., Thompson, J., Martin-Gronert, M., Monk, M., Sheldon, I., Hanson, M., Hales, C., Ozanne, S., & Sheldon, M. (2008). The Effect of Maternal Body Condition Score Before and During Pregnancy on the Glucose Tolerance of Adult Sheep Offspring. Reproductive Sciences, 15(5), 448-456.
https://doi.org/10.1177/1933719107312161, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19524
Sheldon, I., Williams, E., Miller, A., Nash, D., Herath, S., & Sheldon, M. (2008). Uterine diseases in cattle after parturition. The Veterinary Journal, 176(1), 115-121.
https://doi.org/10.1016/j.tvjl.2007.12.031, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19525
Nash, D., Lane, E., Herath, S., Martin Sheldon, I., & Sheldon, M. (2008). ORIGINAL ARTICLE: Endometrial Explant Culture for Characterizing Equine Endometritis. American Journal of Reproductive Immunology, 59(2), 105-117.
https://doi.org/10.1111/j.1600-0897.2007.00548.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19526
Dobson, H., Smith, R., Royal, M., Knight, C., Sheldon, I., & Sheldon, M. (2007). The High-producing Dairy Cow and its Reproductive Performance. Reproduction in Domestic Animals, 42(s2), 17-23.
https://doi.org/10.1111/j.1439-0531.2007.00906.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43618
Grant, E., Lilly, S., Herath, S., Sheldon, I., & Sheldon, M. (2007). Escherichia coli lipopolysaccharide modulates bovine luteal cell function. Veterinary Record, 161(20), 695-696.
https://doi.org/10.1136/vr.161.20.695, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43616
Herath, S., Williams, E., Lilly, S., Gilbert, R., Dobson, H., Bryant, C., Sheldon, I., & Sheldon, M. (2007). Ovarian follicular cells have innate immune capabilities that modulate their endocrine function. Reproduction, 134(5), 683-693.
https://doi.org/10.1530/REP-07-0229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19527
Miller, A., Williams, E., Sibley, K., Herath, S., Lane, E., Fishwick, J., Nash, D., Rycroft, A., Dobson, H., Bryant, C., Sheldon, I., & Sheldon, M. (2007). The effects of Arcanobacterium pyogenes on endometrial function in vitro, and on uterine and ovarian function in vivo. Theriogenology, 68(7), 972-980.
https://doi.org/10.1016/j.theriogenology.2007.07.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19528
Williams, E., Fischer, D., Noakes, D., England, G., Rycroft, A., Dobson, H., Sheldon, I., & Sheldon, M. (2007). The relationship between uterine pathogen growth density and ovarian function in the postpartum dairy cow. Theriogenology, 68(4), 549-559.
https://doi.org/10.1016/j.theriogenology.2007.04.056, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19530
Perrin, L., Bostelmann, R., Sheldon, I., & Sheldon, M. (2007). Reduced conception rates associated with bovine mastitis during a 'window of opportunity'. Veterinary Record, 161(2), 61-62.
https://doi.org/10.1136/vr.161.2.61, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43617
Donofrio, G., Herath, S., Sartori, C., Cavirani, S., Flammini, C., Sheldon, I., & Sheldon, M. (2007). Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function. Reproduction, 134(1), 183-197.
https://doi.org/10.1530/REP-07-0065, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19529
Herath, S., Fischer, D., Werling, D., Williams, E., Lilly, S., Dobson, H., Bryant, C., Sheldon, I., & Sheldon, M. (2006). Expression and Function of Toll-Like Receptor 4 in the Endometrial Cells of the Uterus. Endocrinology, 147(1), 562-570.
https://doi.org/10.1210/en.2005-1113, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19534
Sheldon, I., Lewis, G., LeBlanc, S., Gilbert, R., & Sheldon, M. (2006). Defining postpartum uterine disease in cattle. Theriogenology, 65(8), 1516-1530.
https://doi.org/10.1016/j.theriogenology.2005.08.021, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19533
Herath, S., Dobson, H., Bryant, C., Sheldon, I., & Sheldon, M. (2006). Use of the cow as a large animal model of uterine infection and immunity. Journal of Reproductive Immunology, 69(1), 13-22.
https://doi.org/10.1016/j.jri.2005.09.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19532
Sheldon, I., Wathes, D., Dobson, H., & Sheldon, M. (2006). The management of bovine reproduction in elite herds. The Veterinary Journal, 171(1), 70-78.
https://doi.org/10.1016/j.tvjl.2004.06.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19531
Herath, S. & Sheldon, M. (2005). Expression and Function of Toll-Like Receptor 4 in the Endometrial Cells of the Uterus. Endocrinology, 147(1), 562-570.
https://doi.org/10.1210/en.2005-1113, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11548
Whiteford, L., Sheldon, I., & Sheldon, M. (2005). Association between clinical hypocalcaemia and postpartum endometritis. Veterinary Record, 157(7), 202-204.
https://doi.org/10.1136/vr.157.7.202, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43621
Williams, E., Fischer, D., Pfeiffer, D., England, G., Noakes, D., Dobson, H., Sheldon, I., & Sheldon, M. (2005). Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle. Theriogenology, 63(1), 102-117.
https://doi.org/10.1016/j.theriogenology.2004.03.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19535
von Heimendahl, A., England, G., Sheldon, I., & Sheldon, M. (2004). Influence of Griseofulvin treatment on semen quality in the dog. Animal Reproduction Science, 80(1-2), 175-181.
https://doi.org/10.1016/S0378-4320(03)00140-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43624
Sheldon, M. (2004). Minimum inhibitory concentrations of some antimicrobial drugs against bacteria causing uterine infections in cattle.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43626
Sheldon, I. & Sheldon, M. (2004). The postpartum uterus. Veterinary Clinics of North America: Food Animal Practice, 20(3), 569-591.
https://doi.org/10.1016/j.cvfa.2004.06.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43627
Sheldon, I., Bushnell, M., Montgomery, J., Rycroft, A., & Sheldon, M. (2004). Minimum inhibitory concentrations of some antimicrobial drugs against bacteria causing uterine infections in cattle. Veterinary Record, 155(13), 383-387.
https://doi.org/10.1136/vr.155.13.383, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43622
Sheldon, I., Dobson, H., & Sheldon, M. (2004). Postpartum uterine health in cattle. Animal Reproduction Science, 82-83, 295-306.
https://doi.org/10.1016/j.anireprosci.2004.04.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19536
Sheldon, I., Rycroft, A., Zhou, C., & Sheldon, M. (2004). Association between postpartum pyrexia and uterine bacterial infection in dairy cattle. Veterinary Record, 154(10), 289-293.
https://doi.org/10.1136/vr.154.10.289, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43623
Sheldon, I., Noakes, D., Rycroft, A., Dobson, H., & Sheldon, M. (2004). Effect of intrauterine administration of oestradiol on postpartum uterine bacterial infection in cattle. Animal Reproduction Science, 81(1-2), 13-23.
https://doi.org/10.1016/j.anireprosci.2003.08.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19537
Sheldon, M. (2003). Reproductive challenges facing the cattle industry at the beginning of the 21st century..
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43628
Sheldon, I., Noakes, D., Bayliss, M., Dobson, H., & Sheldon, M. (2003). The effect of oestradiol on postpartum uterine involution in sheep. Animal Reproduction Science, 78(1-2), 57-70.
https://doi.org/10.1016/S0378-4320(03)00048-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43630
Sheldon, I., Noakes, D., Rycroft, A., Dobson, H., & Sheldon, M. (2003). The effect of intrauterine administration of estradiol on postpartum uterine involution in cattle. Theriogenology, 59(5-6), 1357-1371.
https://doi.org/10.1016/S0093-691X(02)01169-X, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19539
Sheldon, I., Noakes, D., Rycroft, A., Dobson, H., & Sheldon, M. (2003). The effect of intrauterine administration of estradiol on postpartum uterine involution in cattle. Theriogenology, 59(5-6), 1357-1371.
https://doi.org/10.1016/S0093-691X(02)01169-X, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa19538
Sheldon, M. (2002). Effect of experimentally induced metritis on uterine involution, acute phase protein response and PGFM secretion in the postpartum ewe.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43635
Sheldon, M. (2002). Influence of uterine bacterial contamination after parturition on ovarian dominant follicle selection and follicle growth and function in cattle.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43636
Sheldon, I., Noakes, D., Rycroft, A., Dobson, H., & Sheldon, M. (2002). Effect of postpartum manual examination of the vagina on uterine bacterial contamination in cows. Veterinary Record, 151(18), 531-534.
https://doi.org/10.1136/vr.151.18.531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43633
Sheldon, I., Noakes, D., Dobson, H., & Sheldon, M. (2002). Effect of the Regressing Corpus Luteum of Pregnancy on Ovarian Folliculogenesis after Parturition in Cattle1. Biology of Reproduction, 66(2), 266-271.
https://doi.org/10.1095/biolreprod66.2.266, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43634
Hewitt, D., Leahy, R., Sheldon, I., England, G., & Sheldon, M. (2001). Cryopreservation of epididymal dog sperm. Animal Reproduction Science, 67(1-2), 101-111.
https://doi.org/10.1016/S0378-4320(01)00090-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43638
Sheldon, I., Noakes, D., Rycroft, A., Dobson, H., & Sheldon, M. (2001). Acute phase protein responses to uterine bacterial contamination in caftle after calving. Veterinary Record, 148(6), 172-175.
https://doi.org/10.1136/vr.148.6.172, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43637
Subandrio, A., Noakes, D., & Sheldon, M. (2000). Peripheral and intrauterine neutrophil function in the cow: the influence of endogenous and exogenous sex steroid hormones. Theriogenology, 53(8), 1591-1608.
https://doi.org/10.1016/S0093-691X(00)00300-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43642
Sheldon, I., Noakes, D., Dobson, H., & Sheldon, M. (2000). The influence of ovarian activity and uterine involution determined by ultrasonography on subsequent reproductive performance of dairy cows. Theriogenology, 54(3), 409-419.
https://doi.org/10.1016/S0093-691X(00)00358-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43645
Sheldon, I., Dobson, H., & Sheldon, M. (2000). Effect of administration of eCG to postpartum cows on folliculogenesis in the ovary ipsilateral to the previously gravid uterine horn and uterine involution. , 119
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa25022
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034028862&partnerID=MN8TOARS
Sheldon, I., Dobson, H., & Sheldon, M. (2000). Effect of administration of eCG to postpartum cows on folliculogenesis in the ovary ipsilateral to the previously gravid uterine horn and uterine involution. Reproduction, 119(1), 157-163.
https://doi.org/10.1530/jrf.0.1190157, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43641
Sheldon, I., Noakes, D., & Sheldon, M. (1998). Comparison of three treatments for bovine endometritis. Veterinary Record, 142(21), 575-579.
https://doi.org/10.1136/vr.142.21.575, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43648
Sheldon, I., Dobson, H., & Sheldon, M. (1993). Effects of gonadotrophin releasing hormone administered 11 days after insemination on the pregnancy rates of cattle to the first and later services. Veterinary Record, 133(7), 160-163.
https://doi.org/10.1136/vr.133.7.160, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29483

Book Chapters

Sheldon, I. & Sheldon, M. (2019). The Metritis Complex in Cattle. Veterinary Reproduction and Obstetrics (pp. 408-433). Elsevier
https://doi.org/10.1016/B978-0-7020-7233-8.00023-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48256
https://www.sciencedirect.com/science/article/pii/B9780702072338000239?via%3Dihub

Other Research Outputs

Cronin, J., Healey, G., MacKintosh, S., Turner, M., Healy, L., Sheldon, I., & Sheldon, M. (2014). Bovine Endometrial Epithelial and Stromal Cells - Standard Operating Procedures for Isolation and Culture of Primary Bovine Endometrial Epithelial and Stromal Cells
https://doi.org/10.13140/RG.2.2.29160.11529, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50246
https://sites.google.com/site/professormartinsheldon/projects/sop

Supervision

Mechanisms regulating the protection of mammalian cells against damage caused by cholesterol-dependent cytolysins from pathogenic bacteria (current)

PhD

Other supervisor: Dr James Cronin
Controlling the Public and Animal Health Threat from Campylobacter Infection in Broiler Chickens by Improving Gut Health and Reducing Inflammation. (awarded 2024)

PhD

Other supervisor: Prof Thomas Wilkinson

Other supervisor: Prof Thomas Wilkinson
Targeting iron metabolism in cancer to induce ferroptosis: a type of programmed cell death (awarded 2024)

PhD

Other supervisor: Dr James Cronin
Understanding the Seasonality of Campylobacter Infection among Commercial Broiler Chickens in the United Kingdom (awarded 2024)

PhD

Other supervisor: Prof Thomas Wilkinson

Taught Modules

PM-249 Human Immunology

The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-352 Reproductive Biology and Medicine

This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility (both male and female) and menopause.
PM-401 Science Communication

This module will encompass a range of communication modes, from presentation of science to the general public to critically analysing a scientific paper. The module will be run as a series of online seminars to prepare, firstly, for a short 3 minute thesis-like presentations to both a professional and non-professional audience. This will be complemented by preparation of short, New Scientist-style articles by each student on the topic of their presentation. Students will be assigned a topic that is appropriate to their degree title. In the latter half of the module, the focus will be on skills-training for writing a scientific paper, preparing the ground for their project dissertations.
PMNM20J Science Communication

This module will encompass a range of communication modes, from presentation of science to the general public to critically analysing a scientific paper. The module will be run as a series of online seminars to prepare, firstly, for a short 3 minute thesis-like presentations to both a professional and non-professional audience. This will be complemented by preparation of short, New Scientist-style articles by each student on the topic of their presentation. Students will be assigned a topic that is appropriate to their degree title. In the latter half of the module, the focus will be on skills-training for writing a scientific paper, preparing the ground for their project dissertations.

Professor Martin Sheldon

Email address

Welsh language proficiency

Twitter Account

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About

Areas Of Expertise

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Research Highlights

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Journal Articles

Book Chapters

Other Research Outputs

Supervision

Mechanisms regulating the protection of mammalian cells against damage caused by cholesterol-dependent cytolysins from pathogenic bacteria (current)

Controlling the Public and Animal Health Threat from Campylobacter Infection in Broiler Chickens by Improving Gut Health and Reducing Inflammation. (awarded 2024)

Targeting iron metabolism in cancer to induce ferroptosis: a type of programmed cell death (awarded 2024)

Understanding the Seasonality of Campylobacter Infection among Commercial Broiler Chickens in the United Kingdom (awarded 2024)

Taught Modules

PM-249 Human Immunology

PM-344 Capstone Project

PM-352 Reproductive Biology and Medicine

PM-401 Science Communication

PMNM20J Science Communication