Senior Lecturer in Medical Engineering
Engineering
Telephone: (01792) 604780
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Room: Academic Office - B205
Second Floor
Engineering East
Bay Campus

Biography

Dr Sanjiv Sharma received his PhD on the development of analytical methods for determination of certain pharmaceuticals and their metabolites using miniaturised separation system in 2001. His PhD supervised by Dr Sunil Kumar Sanghi, was  a part of an Indo- European Community joint research project on miniaturised separation system in collaboration with University of Amsterdam. He then performed postdoctoral research in the areas of high throughput sequencing, clinical proteomics and miniaturised analytical systems in France and Germany from 2001-2004. In 2004, he was awarded a Chevening Technology Fellowship to work with Professor Andrew deMello on microfluidic microreaction systems in the Department of Chemistry at Imperial College London.

On completion of his fellowship he joined the Institute of Biomedical Engineering, Imperial College London to work with Professor Tony Cass in the area of Bionanotechnology and Biosensors. Here he developed minimally invasive microneedles, from photolithographic fabrication to high throughput fabrication, taking these microneedles from the lab to the clinic . Sanjiv was involved in a NIHR (i4i) funded research project involving clinical studies in healthy volunteers and participants with T1D with renowned Endocrinologist Clinicians; Professor Desmond Johnston and Professor Nick Oliver. He has published over 35 research articles and filed patents in Germany, UK and the United States.

Sanjiv is currently a Senior Lecturer in Medical Engineering in the College of Engineering at Swansea University. At Swansea, he is working on therapeutic drug delivery and diagnostic (theranostic) applications of polymeric microneedles.

Areas of Expertise

  • Microneedles
  • Minimally invasive sensors
  • Continuous glucose monitoring (CGM)
  • Continuous lactate monitoring (CLM)
  • Interstitial therapeutic drug monitoring (iTDM)

Publications

  1. & Minimally Invasive Glucose Monitoring Using a Highly Porous Gold Microneedles-Based Biosensor: Characterization and Application in Artificial Interstitial Fluid. Catalysts 9(7), 580
  2. & Microneedle array‐based platforms for future theranostic applications. ChemBioChem
  3. (2019). Recent Developments in Continuous Monitoring Diagnostics with Microneedle Arrays. Presented at 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7), Ho Chi Minh City, Vietnam: BME7 Conference. doi:10.1007/978-981-13-5859-3
  4. & Minimally-invasive Microneedle-based Biosensor Array for Simultaneous Lactate and Glucose Monitoring in Artificial Interstitial Fluid. Electroanalysis 31(2), 374-382.
  5. & Microneedle-based biosensor for minimally-invasive lactate detection. Biosensors and Bioelectronics 123, 152-159.
  6. & A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring. Analytical Methods 10(18), 2088-2095.
  7. & Delivering precision antimicrobial therapy through closed-loop control systems. Journal of Antimicrobial Chemotherapy
  8. & Study of Electrochemical Impedance of a Continuous Glucose Monitoring Sensor and its Correlation with Sensor Performance. IEEE Sensors Letters, 1-1.
  9. & Towards a minimally invasive device for beta-lactam monitoring in humans. Electrochemistry Communications 82, 1-5.
  10. & Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring. Sensing and Bio-Sensing Research 13, 104-108.
  11. & Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring. In Enzymes as Sensors. (pp. 413-427). Elsevier.
  12. & (2017). Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors. Presented at Procedia Technology,, 208-209. doi:10.1016/j.protcy.2017.04.087
  13. & Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring. Analytical and Bioanalytical Chemistry 408(29), 8427-8435.
  14. & (2016). Live demonstration: A portable multi-channel potentiostat for real-time amperometric measurement of multi-electrode sensor arrays. , 2373-2373. Montreal, QC, Canada: IEEE. doi:10.1109/iscas.2016.7539064
  15. (2016). Abstracts from ATTD 2016 9th International Conference on Advanced Technologies & Treatments for DiabetesMilan, Italy–February 3–6, 2016. Presented at Diabetes Technology & Therapeutics,(S1), A-1-A-140. doi:10.1089/dia.2016.2525
  16. & Detection of cardiac biomarker proteins using a disposable based on a molecularly imprinted polymer grafted onto graphite. Microchimica Acta 182(5-6), 975-983.
  17. (2015). Abstracts from ATTD 20158th International Conference on Advanced Technologies & Treatments for DiabetesParis, France—February 18–21, 2015. Presented at Diabetes Technology & Therapeutics,(S1), A-1-A-180. doi:10.1089/dia.2015.1525
  18. & Dip-pen patterning of poly(9,9-dioctylfluorene) chain-conformation-based nano-photonic elements. Nature Communications 6, 5977
  19. & Aptamer-based biosensors for the rapid visual detection of flu viruses. Chem. Commun. 50(98), 15533-15536.
  20. & Protein-responsive polymers for point-of-care detection of cardiac biomarker. Sensors and Actuators B: Chemical 196, 123-132.
  21. (2014). DEVELOPMENT OF A NOVEL MICROPROBE ARRAY CONTINUOUS GLUCOSE SENSOR FOR TYPE 1 DIABETES: INTERFERENCE STUDIES. Presented at DIABETES TECHNOLOGY & THERAPEUTICS,
  22. & Scaling advantages and constraints in miniaturized capture assays for single cell protein analysis. Lab on a Chip 13(11), 2066
  23. & Smart plastic antibody material (SPAM) tailored on disposable screen printed electrodes for protein recognition: Application to myoglobin detection. Biosensors and Bioelectronics 45, 237-244.

See more...

Teaching

  • EG-233 Placement Preparation: Engineering Industrial Year

    This generic cross-disciplinary module is for all students who have enrolled (or transferred) onto the Engineering Year in Industry scheme. The module focuses on the underpinning and fundamental requisites required to gain, enter and progress effectively through an industrial placement. Learners will be introduced to a) sourcing placements, CV writing and application techniques; (b) interview techniques - how to pitch yourself and be successful; (c) workplace fundamentals and IP awareness, behaviours and expectations; (d) key employability skills; getting the most from your Industrial Placement; and (e) health and safety in the workplace.

  • EG-236 Design for Medical Engineering

    This module has two main components: Component 1 (Engineering drawing and CAD): The first is the development of their engineering drawing skills using a CAD software package to the required British Standard. Component 2 (Design project): The second component involves the students working together in groups to address a medical device design brief developed with a local rehabilitation engineering unit. Students will be introduced to the medical design development process, which they will follow in order to develop their product concepts. There will be an emphasis on the importance of identifying end user needs (i.e. functional requirements), and how these inform the design process. The importance of having a robust product design specification is emphasised, along with an introduction to innovative design tools and approaches. The selected concept design will be developed virtually in CAD. Each group participant will be responsible for a component or element of the device, which will then be part of the overall product assembly which will be outlined in the group element of the report.

  • EG-238 Experimental Studies for Medical Engineers

    The course introduces the students to experimental studies in a wide range of subjects. Each experiment is self contained and the student will present the findings in written form through a lab report which will have a set of experiment specific questions to answer. This written report also forms the basis for the assessment. All students work in groups and carry out five experiments which vary according to discipline, however the assignments are all individually submitted. The students keep a log-book of the experimental observations and results, which is used for reference for the technical report from each experiment written-up in the week after the experiment.

  • EGDM03 Individual Research Project

    The module involves the application of advanced scientific and engineering principles to the solution of a practical problem coming from outside engineering.The student will be working independently on a substantial, individually assigned task, using accepted planning procedures. It will require and develop self-organisation and a critical evaluation of options and results, as well as developing technical knowledge in the topic of research.The student will develop a clear view on the integration of medical engineering in a professional environment.

  • EGM403 Implant Engineering 2

    This module is an advanced look at the design, fabrication and optimisation of medical implants and prosthetics. Case studies will be used to bring together engineering concepts and apply them to key devices that are used to treat disease and assist patients.

  • EGNM07 Principles of Nanomedicine

    This module will cover the broad range of subjects which encompass the discipline nanomedicine. Building on the foundation of a knowledge of nanotechnology this module will focus on medical applications including biological markers, diagnostics, therapeutics and drug delivery vehicles.

Supervision

  • Creation and Optimisation of Plasma Etch Processes for the Manufacture of Silicon Microstructures (current)

    Student name:
    MPhil
    Other supervisor: Prof Owen Guy
  • Development of Microneedle devices for drug delivery (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • Development of a Microneedle Biosensor for Pregnancy Determination (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • Microneedles for Theranostics (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy

Career History

Start Date End Date Position Held Location
September 2011 September 2017 Research Fellow Imperial College London

Invited Presentations, Lectures and Conferences

Date Description
May 2017 Minimally invasive, continuous glucose monitoring in human subjects. 5th International Congress on Bio-Sensing Technologies.
June 2018 “Microneedle array-based platform for future theranostic applications” - 28th Anniversary World Congress on Biosensors - USA
June 2018 “Towards a fully scalable minimally invasive, continuous glucose monitoring sensor, Type1 diabetes” World Congress on Biosensors
June 2019 "Development of a minimally invasive continuous lactate monitoring sensor for clinical and sports applications" BioSensing Tech.

Student successes

 oliver-howellsMy PhD student Olivia Howells won the Public engagement award for "Outstanding contribution to public engagement" during her postgraduate studies.







Dang Khoa Trans My student Dang Khoa Trans was awarded the IMechE award for the best MEng Research Project for 2018. His research project focussed on microneedle based delivery of insulin, an area that will impact people suffering from Diabetes.