Dr Spyridon Theofilopoulos

Uchafbwyntiau Ymchwil

1. Meljon, A., Theofilopoulos, S., Shackleton, C., Watson, G., Javitt, N., Knolker, H., Saini, R., Arenas, E., Wang, Y., Griffiths, W., Griffiths, W., Wang, Y., & Theofilopoulos, S. (2012). Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. Journal of Lipid Research, 53(11), 2469-2483.

   https://doi.org/10.1194/jlr.d028233, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12880

   http://dx.doi.org/10.1194/jlr.d028233
2. Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.

   https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057

   http://dx.doi.org/10.1016/j.bbalip.2018.11.006
3. Cajanek, L., Ganji, R., Henriques-Oliveira, C., Theofilopoulos, S., Konik, P., Bryja, V., Arenas, E., & Theofilopoulos, S. (2013). Tiam1 Regulates the Wnt/Dvl/Rac1 Signaling Pathway and the Differentiation of Midbrain Dopaminergic Neurons. Molecular and Cellular Biology, 33(1), 59-70.

   https://doi.org/10.1128/mcb.00745-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52577

   http://dx.doi.org/10.1128/mcb.00745-12
4. Ribeiro, D., Ellwanger, K., Glagow, D., Theofilopoulos, S., Corsini, N., Martin-Villalba, A., Niehrs, C., & Arenas, E. (2011). Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis. PLoS ONE, 6(2), e15786

   https://doi.org/10.1371/journal.pone.0015786, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52578

   http://dx.doi.org/10.1371/journal.pone.0015786
5. Griffiths, W., Wang, Y., Brenton, A., Hall, L., Arenas, E., Lockhart, A., Theofilopoulos, S., Sjövall, J., & Ogundare, M. (2010). Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?. Journal of Biological Chemistry, 285(7), 4666-4679.

   https://doi.org/10.1074/jbc.m109.086678, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52579

   http://dx.doi.org/10.1074/jbc.m109.086678
6. Griffiths, W., Arenas, E., Sjövall, J., Karu, K., Theofilopoulos, S., Hornshaw, M., Sacchetti, P., Bodin, K., Sousa, K., Woffendin, G., & Wang, Y. (2009). Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular BioSystems, 5(5), 529

   https://doi.org/10.1039/b819502a, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52580

   http://dx.doi.org/10.1039/b819502a
7. Theofilopoulos, S., Lykidis, A., Leondaritis, G., Mangoura, D., & Theofilopoulos, S. (2008). Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1781(11-12), 731-742.

   https://doi.org/10.1016/j.bbalip.2008.09.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52581

   http://dx.doi.org/10.1016/j.bbalip.2008.09.001
8. Mangoura, D., Theofilopoulos, S., Karouzaki, S., Tsirimonaki, E., & Theofilopoulos, S. (2006). 12-O-tetradecanoyl-phorbol-13-acetate-dependent up-regulation of dopaminergic gene expression requires Ras and neurofibromin in human IMR-32 neuroblastoma. Journal of Neurochemistry, 97, 97-103.

   https://doi.org/10.1111/j.1471-4159.2005.03483.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52582

   http://dx.doi.org/10.1111/j.1471-4159.2005.03483.x
9. S. Riaz, S., Theofilopoulos, S., Jauniaux, E., Stern, G., & Bradford, H. (2004). The differentiation potential of human foetal neuronal progenitor cells in vitro. Developmental Brain Research, 153(1), 39-51.

   https://doi.org/10.1016/j.devbrainres.2004.07.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52583

   http://dx.doi.org/10.1016/j.devbrainres.2004.07.006
10. Theofilopoulos, S., Goggi, J., Riaz, S., Jauniaux, E., Stern, G., & Bradford, H. (2001). Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor. Developmental Brain Research, 127(2), 111-122.

    https://doi.org/10.1016/s0165-3806(01)00125-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52584

    http://dx.doi.org/10.1016/s0165-3806(01)00125-0
11. Goggi, J., Theofilopoulos, S., Riaz, S., Jauniaux, E., Stern, G., & Bradford, H. (2000). The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurones in culture. NeuroReport, 11(18), 3937-3941.

    https://doi.org/10.1097/00001756-200012180-00007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52585

    http://dx.doi.org/10.1097/00001756-200012180-00007
12. Theofilopoulos, S., Oliveira, W., Yang, S., Yutuc, E., Saeed, A., Abdel-Khalik, J., Ullgren, A., Cedazo-Minguez, A., Björkhem, I., Wang, Y., Griffiths, W., & Arenas, E. (2019). 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. Journal of Biological Chemistry, 294(11), 4169-4176.

    https://doi.org/10.1074/jbc.ra118.005639, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48277

    http://dx.doi.org/10.1074/jbc.ra118.005639
13. Theofilopoulos, S. & Arenas, E. (2015). Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration. F1000Prime Reports, 7

    https://doi.org/10.12703/P7-37, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34742
14. Theofilopoulos, S., Griffiths, W., Crick, P., Yang, S., Meljon, A., Ogundare, M., Kitambi, S., Lockhart, A., Tuschl, K., Clayton, P., Morris, A., Martinez, A., Reddy, M., Martinuzzi, A., Bassi, M., Honda, A., Mizuochi, T., Kimura, A., Nittono, H...., & Wang, Y. (2014). Cholestenoic acids regulate motor neuron survival via liver X receptors. Journal of Clinical Investigation, 124(11), 4829-4842.

    https://doi.org/10.1172/jci68506, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34741

    http://dx.doi.org/10.1172/jci68506
15. Theofilopoulos, S., Wang, Y., Kitambi, S., Sacchetti, P., Sousa, K., Bodin, K., Kirk, J., Saltó, C., Gustafsson, M., Toledo, E., Karu, K., Gustafsson, J., Steffensen, K., Ernfors, P., Sjövall, J., Griffiths, W., & Arenas, E. (2013). Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology, 9(2), 126-133.

    https://doi.org/10.1038/nchembio.1156, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34740

    http://dx.doi.org/10.1038/nchembio.1156
16. Sacchetti, P., Sousa, K., Hall, A., Liste, I., Steffensen, K., Theofilopoulos, S., Parish, C., Hazenberg, C., Richter, L., Hovatta, O., Gustafsson, J., & Arenas, E. (2009). Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells. Cell Stem Cell, 5(4), 409-419.

    https://doi.org/10.1016/j.stem.2009.08.019, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34739

    http://dx.doi.org/10.1016/j.stem.2009.08.019
17. Hedlund, E., Belnoue, L., Theofilopoulos, S., Salto, C., Bye, C., Parish, C., Deng, Q., Kadkhodaei, B., Ericson, ., Arenas, E., Perlmann, T., & Simon, A. (2016). Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Scientific Reports, 6(1), 26448

    https://doi.org/10.1038/srep26448, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39501

    http://dx.doi.org/10.1038/srep26448
18. Gyllborg, D., Ahmed, M., Toledo, E., Theofilopoulos, S., Yang, S., ffrench-Constant, C., & Arenas, E. (2018). The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation. Stem Cell Reports, 11(3), 651-664.

    https://doi.org/10.1016/j.stemcr.2018.07.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43582

    http://dx.doi.org/10.1016/j.stemcr.2018.07.014
19. Meljon, A., Crick, P., Yutuc, E., Yau, J., Seckl, J., Theofilopoulos, S., Arenas, E., Wang, Y., & Griffiths, W. (2019). Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules, 9(4), 149

    https://doi.org/10.3390/biom9040149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50029
20. Griffiths, W., Abdel-Khalik, J., Moore, S., Wijeyekoon, R., Crick, P., Yutuc, E., Farrell, K., Breen, D., Williams-Gray, C., Theofilopoulos, S., Arenas, E., Trupp, M., Barker, R., & Wang, Y. (2021). The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features. Frontiers in Aging Neuroscience, 13, 685594

    https://doi.org/10.3389/fnagi.2021.685594, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57043

Holl Ymchwil

• Untitled (cyfredol)

  PhD

  Goruchwyliwr arall: Dr Spyridon Theofilopoulos

  Goruchwyliwr arall: Prof Yuqin Wang