Institute of Life Science 1 internal Atrium view up

Dr Paul Facey

Athro Cyswllt, Biomedical Sciences

p.facey@abertawe.ac.uk

Swyddfa Academaidd - 111
Llawr Cyntaf
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0002-3229-0255

ResearchGate

Trosolwg

Enillodd Paul ei PhD yn 2006 mewn geneteg ac esblygiad poblogaeth planhigion ac yna symudodd ymlaen i ddefnyddio technegau moleciwlaidd mewn Dyframaethu.

Yn 2009, cymerodd Paul swydd ôl-ddoethurol yn SUMS lle bu’n gweithio ar ymateb straen y model Actinomycete Streptomyces coelicolor.

Ers hynny mae Paul wedi cynnal ei ddiddordeb mewn genomeg bacteriol - gan ddatblygu cydweithrediadau â phartneriaid diwydiannol sy'n edrych ar ddadorchuddio'r cydadwaith rhwng y microbiome gastroberfeddol a'r gwesteiwr.

Ar hyn o bryd mae Paul yn gweithio ar ddatgelu buddion iechyd hirdymor atchwanegiadau probiotig aml-straen gyda Laura Baker.

Meysydd Arbenigedd

Phylogenetics
Esblygiad genom
Rhyngweithiadau gwesteiwr microbiome
Esblygiad Hominin

Uchafbwyntiau Gyrfa

Ymchwil

Mae diddordebau ymchwil Paul yn gorwedd o fewn nodweddu a ffylogenomeg bacteria symbiotig a chymesur mewn gwahanol westeion anifeiliaid. Gan ddefnyddio repertoire eang o dechnegau biowybodegol mae ganddo ddiddordeb mewn nodweddu ynysoedd bacteriol a chraffu ar ddilyniannau genom cyfan ar gyfer nodweddion newydd. Mae ei ymchwil gyfredol yn canolbwyntio ar ddefnyddio dull dan arweiniad genom mewn ymgais i egluro'r mecanweithiau moleciwlaidd sy'n sail i fuddion iechyd bacteria probiotig.

Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Parsons, R., Kocinaj, A., Pulido, G., Prendergast, S., Parsons, A., Facey, P., & Hirth, F. (2022). Alpha-SYNUCLEINOPATHY reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway. Human Molecular Genetics, 31(17), 2918-2933.
https://doi.org/10.1093/hmg/ddac077, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59792
Webberley, T., Masetti, G., Baker, L., Dally, J., Hughes, T., Marchesi, J., Jack, A., Plummer, S., Ramanathan, G., Facey, P., & Michael, D. (2021). The Impact of Lab4 Probiotic Supplementation in a 90-Day Study in Wistar Rats. Frontiers in Nutrition, 8
https://doi.org/10.3389/fnut.2021.778289, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59001
Parsons, R. & Facey, P. (2021). Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution. Biomolecules, 11(10), 1418
https://doi.org/10.3390/biom11101418, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58145
Baker, L., Webberley, T., Masetti, G., Hughes, T., Marchesi, J., Jack, A., Joyce, T., Allen, M., Plummer, S., Michael, D., Ramanathan, G., Del Sol Abascal, R., & Facey, P. (2021). A genome guided evaluation of the Lab4 probiotic consortium. Genomics, 113(6), 4028-4038.
https://doi.org/10.1016/j.ygeno.2021.08.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57777
Quinn, G., Abdelhameed, A., Banat, A., Alharbi, N., Baker, L., Castro, H., Dyson, P., Facey, P., Cobice, D., Terra, L., Adu, S., Swain, M., & Banat, I. (2021). Streptomyces Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts. Applied Sciences, 11(11), 4923
https://doi.org/10.3390/app11114923, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56959
Quinn, G., Abdelhameed, A., Alharbi, N., Cobice, D., Adu, S., Swain, M., Castro, H., Facey, P., Bakshi, H., Tambuwala, M., & Banat, I. (2020). The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts. Applied Sciences, 11(1), 173
https://doi.org/10.3390/app11010173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55964
Terra, L., Dyson, P., Hitchings, M., Thomas, L., Abdelhameed, A., Banat, I., Gazze, S., Vujaklija, D., Facey, P., Francis, L., Quinn, G., & Dyson, P. (2018). A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens. Frontiers in Microbiology, 9
https://doi.org/10.3389/fmicb.2018.02458, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44961
http://dx.doi.org/10.3389/fmicb.2018.02458
Facey, P., Hitchings, M., Saavedra-Garcia, P., Fernandez-Martinez, L., Dyson, P., Abascal, R., Dyson, P., Del Sol Abascal, R., Hitchings, M., & Facey, P. (2009). Streptomyces coelicolor Dps-like proteins: Differential dual roles in response to stress during vegetative growth and in nucleoid condensation during reproductive cell division. Molecular Microbiology, 73(6), 1186-202.
https://doi.org/10.1111/j.1365-2958.2009.06848.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9837
Akpe San Roman, S., Facey, P., Fernandez-Martinez, L., Rodriguez, C., Vallin, C., Del Sol, R., Dyson, P., Dyson, P., Del Sol Abascal, R., & Facey, P. (2010). A heterodimer of EsxA and EsxB is involved in sporulation and is secreted by a type VII secretion system in Streptomyces coelicolor. Microbiology, 156(6), 1719-1729.
https://doi.org/10.1099/mic.0.037069-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10232
Hitchings, M., Facey, P., Sevikova, B., Novakova, R., Hitchings, M., Crack, J., Kormanec, J., Dyson, P., Abascal, R., Dyson, P., Del Sol Abascal, R., & Facey, P. (2011). The dpsA Gene of Streptomyces coelicolor: Induction of Expression from a Single Promoter in Response to Environmental Stress or during. PlosOne, 6(9), e25593
https://doi.org/10.1371/journal.pone.0025593, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10243
Corradi, N., Liman, R., Facey, P., Keulen, G., Dyson, P., Sol, R., Del Sol Abascal, R., & Van Keulen, G. (2013). A Laterally Acquired Galactose Oxidase-Like Gene Is Required for Aerial Development during Osmotic Stress in Streptomyces coelicolor. PLoS ONE, 8(1), e54112
https://doi.org/10.1371/journal.pone.0054112, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13761
Dyson, P., Del Sol Abascal, R., Francis, L., & Facey, P. (2013). A novel bifunctional histone protein in Streptomyces: a candidate for structural coupling between DNA conformation and transcription during development and stress?. Nucleic Acids Research
https://doi.org/10.1093/nar/gkt180, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14456
Dale, C., Facey, P., Hitchings, M., Williams, J., Skibinski, D., Dyson, P., Sol, R., & Del Sol Abascal, R. (2013). The Evolution of an Osmotically Inducible dps in the Genus Streptomyces. PLoS ONE, 8(4)
https://doi.org/10.1371/journal.pone.0060772, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14547
Pachebat, J., Keulen, G., Whitten, M., Girdwood, S., Sol, R., Dyson, P., Facey, P., Dyson, P., Walker, M., Del Sol Abascal, R., Van Keulen, G., & Facey, P. (2013). Draft Genome Sequence of Rhodococcus rhodnii Strain LMG5362, a Symbiont of Rhodnius prolixus (Hemiptera, Reduviidae, Triatominae), the Principle Vector of Trypanosoma cruzi. Genome Announcements, 1(3), e00329-13-e00329-13.
https://doi.org/10.1128/genomeA.00329-13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14827
Del Sol , R., Jones, H., Dyson, P., Del Sol Abascal, R., Hitchings, M., & Facey, P. (2014). A tale of tails: deciphering the contribution of terminal tails to the biochemical properties of two Dps proteins from Streptomyces coelicolor.. Cell Mol Life Sci
https://doi.org/10.1007/s00018-014-1658-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18070
Chen, X., Zhang, B., Xiao, J., Ju, F., Li, S., Ren, C., An, L., Chen, T., Liu, G., Facey, P., Mullins, J., & Dyson, P. (2015). RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723. Future Microbiology, 10(3), 325-335.
https://doi.org/10.2217/fmb.14.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20615
http://www.futuremedicine.com/doi/abs/10.2217/fmb.14.131?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov
Del Sol Abascal, R., Dyson, P., Walker, M., Hitchings, M., Facey, P., & Meric, G. (2015). Draft genomes, phylogenetic reconstruction and comparative genomics of two novel cohabiting bacterial symbionts isolated from Frankliniella occidentalis.. Genome Biology and Evolution
https://doi.org/10.1093/gbe/evv136, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22772
http://gbe.oxfordjournals.org/content/early/2015/07/15/gbe.evv136.long
Facey, P., Fernández-Martínez, L., Evans, M., Mitchell, J., Bodger, O., Dyson, P., Walker, M., & Del Sol Abascal, R. (2016). Symbiont-mediated RNA interference in insects. Proceedings of the Royal Society B: Biological Sciences, 283(1825), 20160042
https://doi.org/10.1098/rspb.2016.0042, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26533
Chen, X., Hitchings, M., Mendoza, J., Balanza, V., Facey, P., Dyson, P., Bielza, P., Sol, R., & Del Sol Abascal, R. (2017). Comparative Genomics of Facultative Bacterial Symbionts Isolated from European Orius Species Reveals an Ancestral Symbiotic Association. Frontiers in Microbiology, 8
https://doi.org/10.3389/fmicb.2017.01969, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35991
Zhang, B., Tang, S., Chen, X., Zhang, G., Zhang, W., Chen, T., Liu, G., Li, S., Dos Santos, L., Castro, H., Facey, P., Hitchings, M., & Dyson, P. (2018). Streptomyces qaidamensis sp. nov., isolated from sand in the Qaidam Basin, China. The Journal of Antibiotics
https://doi.org/10.1038/s41429-018-0080-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41085
Hipkin, C. & Facey, P. (2009). Biological Flora of the British Isles:Coincya monensis(L.) Greuter & Burdet ssp.monensis(Rhyncosinapis monensis(L.) Dandy ex A.R. Clapham) and ssp.cheiranthos(Vill.) Aedo, Leadley & Muñoz Garm. (Rhyncosinapis cheiranthos(Vill.) Dandy). Journal of Ecology, 97(5), 1101-1116.
https://doi.org/10.1111/j.1365-2745.2009.01532.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12788
Facey, P., Sevcikova, B., Novakova, R., Hitchings, M., Crack, J., Kormanec, J., Dyson, P., & Del Sol Abascal, R. (2011). Correction: The dpsA Gene of Streptomyces coelicolor: Induction of Expression from a Single Promoter in Response to Environmental Stress or during Development. PLoS ONE, 6(11)
https://doi.org/10.1371/annotation/8fedd9bb-d84e-4d7b-bc71-3321e652198d, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63747
http://dx.doi.org/10.1371/annotation/8fedd9bb-d84e-4d7b-bc71-3321e652198d

Holl Ymchwil

Erthyglau Cylchgronau

Parsons, R., Kocinaj, A., Pulido, G., Prendergast, S., Parsons, A., Facey, P., & Hirth, F. (2022). Alpha-SYNUCLEINOPATHY reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway. Human Molecular Genetics, 31(17), 2918-2933.
https://doi.org/10.1093/hmg/ddac077, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59792
Webberley, T., Masetti, G., Baker, L., Dally, J., Hughes, T., Marchesi, J., Jack, A., Plummer, S., Ramanathan, G., Facey, P., & Michael, D. (2021). The Impact of Lab4 Probiotic Supplementation in a 90-Day Study in Wistar Rats. Frontiers in Nutrition, 8
https://doi.org/10.3389/fnut.2021.778289, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59001
Baker, L., Webberley, T., Masetti, G., Hughes, T., Marchesi, J., Jack, A., Joyce, T., Allen, M., Plummer, S., Michael, D., Ramanathan, G., Del Sol Abascal, R., & Facey, P. (2021). A genome guided evaluation of the Lab4 probiotic consortium. Genomics, 113(6), 4028-4038.
https://doi.org/10.1016/j.ygeno.2021.08.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57777
Parsons, R. & Facey, P. (2021). Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution. Biomolecules, 11(10), 1418
https://doi.org/10.3390/biom11101418, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58145
Quinn, G., Abdelhameed, A., Banat, A., Alharbi, N., Baker, L., Castro, H., Dyson, P., Facey, P., Cobice, D., Terra, L., Adu, S., Swain, M., & Banat, I. (2021). Streptomyces Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts. Applied Sciences, 11(11), 4923
https://doi.org/10.3390/app11114923, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56959
Quinn, G., Abdelhameed, A., Alharbi, N., Cobice, D., Adu, S., Swain, M., Castro, H., Facey, P., Bakshi, H., Tambuwala, M., & Banat, I. (2020). The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts. Applied Sciences, 11(1), 173
https://doi.org/10.3390/app11010173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55964
Terra, L., Dyson, P., Hitchings, M., Thomas, L., Abdelhameed, A., Banat, I., Gazze, S., Vujaklija, D., Facey, P., Francis, L., Quinn, G., & Dyson, P. (2018). A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens. Frontiers in Microbiology, 9
https://doi.org/10.3389/fmicb.2018.02458, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44961
http://dx.doi.org/10.3389/fmicb.2018.02458
Zhang, B., Tang, S., Chen, X., Zhang, G., Zhang, W., Chen, T., Liu, G., Li, S., Dos Santos, L., Castro, H., Facey, P., Hitchings, M., & Dyson, P. (2018). Streptomyces qaidamensis sp. nov., isolated from sand in the Qaidam Basin, China. The Journal of Antibiotics
https://doi.org/10.1038/s41429-018-0080-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41085
Chen, X., Hitchings, M., Mendoza, J., Balanza, V., Facey, P., Dyson, P., Bielza, P., Sol, R., & Del Sol Abascal, R. (2017). Comparative Genomics of Facultative Bacterial Symbionts Isolated from European Orius Species Reveals an Ancestral Symbiotic Association. Frontiers in Microbiology, 8
https://doi.org/10.3389/fmicb.2017.01969, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35991
Facey, P., Fernández-Martínez, L., Evans, M., Mitchell, J., Bodger, O., Dyson, P., Walker, M., & Del Sol Abascal, R. (2016). Symbiont-mediated RNA interference in insects. Proceedings of the Royal Society B: Biological Sciences, 283(1825), 20160042
https://doi.org/10.1098/rspb.2016.0042, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26533
Chen, X., Zhang, B., Xiao, J., Ju, F., Li, S., Ren, C., An, L., Chen, T., Liu, G., Facey, P., Mullins, J., & Dyson, P. (2015). RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723. Future Microbiology, 10(3), 325-335.
https://doi.org/10.2217/fmb.14.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20615
http://www.futuremedicine.com/doi/abs/10.2217/fmb.14.131?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov
Del Sol Abascal, R., Dyson, P., Walker, M., Hitchings, M., Facey, P., & Meric, G. (2015). Draft genomes, phylogenetic reconstruction and comparative genomics of two novel cohabiting bacterial symbionts isolated from Frankliniella occidentalis.. Genome Biology and Evolution
https://doi.org/10.1093/gbe/evv136, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22772
http://gbe.oxfordjournals.org/content/early/2015/07/15/gbe.evv136.long
Del Sol , R., Jones, H., Dyson, P., Del Sol Abascal, R., Hitchings, M., & Facey, P. (2014). A tale of tails: deciphering the contribution of terminal tails to the biochemical properties of two Dps proteins from Streptomyces coelicolor.. Cell Mol Life Sci
https://doi.org/10.1007/s00018-014-1658-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18070
Dyson, P., Del Sol Abascal, R., Francis, L., & Facey, P. (2013). A novel bifunctional histone protein in Streptomyces: a candidate for structural coupling between DNA conformation and transcription during development and stress?. Nucleic Acids Research
https://doi.org/10.1093/nar/gkt180, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14456
Dale, C., Facey, P., Hitchings, M., Williams, J., Skibinski, D., Dyson, P., Sol, R., & Del Sol Abascal, R. (2013). The Evolution of an Osmotically Inducible dps in the Genus Streptomyces. PLoS ONE, 8(4)
https://doi.org/10.1371/journal.pone.0060772, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14547
Pachebat, J., Keulen, G., Whitten, M., Girdwood, S., Sol, R., Dyson, P., Facey, P., Dyson, P., Walker, M., Del Sol Abascal, R., Van Keulen, G., & Facey, P. (2013). Draft Genome Sequence of Rhodococcus rhodnii Strain LMG5362, a Symbiont of Rhodnius prolixus (Hemiptera, Reduviidae, Triatominae), the Principle Vector of Trypanosoma cruzi. Genome Announcements, 1(3), e00329-13-e00329-13.
https://doi.org/10.1128/genomeA.00329-13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14827
Corradi, N., Liman, R., Facey, P., Keulen, G., Dyson, P., Sol, R., Del Sol Abascal, R., & Van Keulen, G. (2013). A Laterally Acquired Galactose Oxidase-Like Gene Is Required for Aerial Development during Osmotic Stress in Streptomyces coelicolor. PLoS ONE, 8(1), e54112
https://doi.org/10.1371/journal.pone.0054112, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13761
Hitchings, M., Facey, P., Sevikova, B., Novakova, R., Hitchings, M., Crack, J., Kormanec, J., Dyson, P., Abascal, R., Dyson, P., Del Sol Abascal, R., & Facey, P. (2011). The dpsA Gene of Streptomyces coelicolor: Induction of Expression from a Single Promoter in Response to Environmental Stress or during. PlosOne, 6(9), e25593
https://doi.org/10.1371/journal.pone.0025593, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10243
Facey, P., Sevcikova, B., Novakova, R., Hitchings, M., Crack, J., Kormanec, J., Dyson, P., & Del Sol Abascal, R. (2011). Correction: The dpsA Gene of Streptomyces coelicolor: Induction of Expression from a Single Promoter in Response to Environmental Stress or during Development. PLoS ONE, 6(11)
https://doi.org/10.1371/annotation/8fedd9bb-d84e-4d7b-bc71-3321e652198d, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63747
http://dx.doi.org/10.1371/annotation/8fedd9bb-d84e-4d7b-bc71-3321e652198d
Akpe San Roman, S., Facey, P., Fernandez-Martinez, L., Rodriguez, C., Vallin, C., Del Sol, R., Dyson, P., Dyson, P., Del Sol Abascal, R., & Facey, P. (2010). A heterodimer of EsxA and EsxB is involved in sporulation and is secreted by a type VII secretion system in Streptomyces coelicolor. Microbiology, 156(6), 1719-1729.
https://doi.org/10.1099/mic.0.037069-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10232
Hipkin, C. & Facey, P. (2009). Biological Flora of the British Isles:Coincya monensis(L.) Greuter & Burdet ssp.monensis(Rhyncosinapis monensis(L.) Dandy ex A.R. Clapham) and ssp.cheiranthos(Vill.) Aedo, Leadley & Muñoz Garm. (Rhyncosinapis cheiranthos(Vill.) Dandy). Journal of Ecology, 97(5), 1101-1116.
https://doi.org/10.1111/j.1365-2745.2009.01532.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12788
Facey, P., Hitchings, M., Saavedra-Garcia, P., Fernandez-Martinez, L., Dyson, P., Abascal, R., Dyson, P., Del Sol Abascal, R., Hitchings, M., & Facey, P. (2009). Streptomyces coelicolor Dps-like proteins: Differential dual roles in response to stress during vegetative growth and in nucleoid condensation during reproductive cell division. Molecular Microbiology, 73(6), 1186-202.
https://doi.org/10.1111/j.1365-2958.2009.06848.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9837

Goruchwyliaeth

A genome guided evalution of cadidate probiotics, from the Lactobacillus and Bifdobacterium genera. (dyfarnwyd 2022)

PhD

Goruchwyliwr arall: Dr Ricardo Del Sol Abascal
Investigating the potential for probiotic bacteria to be used as biotherapeutic interventions for colorectal cancer. (dyfarnwyd 2023)

MSc

Goruchwyliwr arall: Dr Claire Morgan
Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. (dyfarnwyd 2024)

MSc

Goruchwyliwr arall: Dr Ricardo Del Sol Abascal

Modiwlau a Addysgir

PM-149 Genetics, Genomics & Evolution

The module will provide a foundation in genetics and evolution. Concepts such as DNA discovery, structure and replication, gene transcription and translation, mechanisms of gene transmission, genome organisation, epigenetic modifications and mutations will be covered with an appreciation of how how these mechanisms have an impact on human disease and antibiotic resistance. The latter part of the module will start with the work of Plato, Cuvier, Lamarck, Wallace and Darwin and how they (and others) influenced the development of an evolutionary theory framework. Using this knowledge the module will then look at the processes involved in speciation and how they can be applied at both the gene and whole organismal level.
PM-252 Molecular Evolution

The module aims to critically evaluate concepts and apply the scientific methods pertaining to the study of molecular evolution, in prokaryotic and eukaryotic organisms.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-361C Biowybodeg: O ddilyniant i swyddogaeth

Mae argaeledd cynyddol dilyniannau genom a data strwythur protein yn mynnu bod biolegwyr moleciwlaidd yn hyfedr wrth berfformio dadansoddiadau data helaeth i arwain a chefnogi ymchwil draddodiadol mewn labordy. Bydd y Modiwl hwn yn darparu sylfaen ddamcaniaethol a hyfforddiant ymarferol ar offer cyfrifiadol a ddefnyddir ar hyn o bryd i gydosod a holi dilyniannau genom, casglu swyddogaethau genynnau a phrotein, ac i archwilio data strwythur protein.
PM-400 Advanced Research Project A

The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period of time. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices and health informatics. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference. The advanced research project is divided between 2 modules, PM-400 and PM-405.
PM-400C Prosiect Ymchwil Uwch A

Mae'r prosiect ymchwil uwch yn elfen allweddol o'r flwyddyn astudio olaf. Mae'n rhoi cyfle i fyfyrwyr gael profiad o ymgymryd ag ymchwil arloesol yn y Sefydliad Gwyddor Bywyd a'r Ganolfan NanoIechyd am gyfnod estynedig o amser. Bydd y prosiect yn canolbwyntio ar un o'r themâu ymchwil canlynol sy'n berthnasol i'r gwyddorau meddygol: Biofarcwyr a Genynnau; Microbau ac Imiwnedd; Dyfeisiau. Bydd myfyrwyr yn defnyddio amrywiaeth o dechnegau dadansoddi uwch i ymchwilio i bwnc penodol. Yn ogystal, byddant yn cael profiad o lunio cynnig ymchwil a chyflwyno eu data mewn amrywiaeth o fformatau. Dynodir themâu ymchwil sy'n briodol i deitl gradd penodol. Er enghraifft, os yw myfyriwr yn astudio Geneteg, gellir dynodi prosiect yn ymchwilio i weithrediad gennyn mewn fector pryfed clefyd trofannol, gan ddefnyddio techneg ymyrraeth RNA. Rhennir y prosiect ymchwil uwch rhwng dau fodiwl, PM-400 a PM-405.
PM-405 Advanced Research Project Dissertation

The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period. The projects undertaken will fall into one of the current medically-related research themes. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title.
PM-405C Traethawd Hir Prosiect Ymchwil Uwch

Mae'r prosiect ymchwil uwch yn elfen allweddol o'r flwyddyn astudio olaf, gan roi cyfle i fyfyrwyr gael profiad o ymchwil arloesol yn y Sefydliad Gwyddor Bywyd a'r Ganolfan NanoIechyd am gyfnod estynedig o amser. Bydd y prosiect yn seiliedig ar un o'r themâu ymchwil sy'n ymwneud â'r gwyddorau meddygol. Bydd myfyrwyr yn defnyddio amrywiaeth o dechnegau dadansoddi uwch i ymchwilio i bwnc penodol. Yn ogystal, cânt brofiad o lunio cynnig ymchwil a chyflwyno eu data mewn amrywiaeth o fformatau. Dynodir pynciau ymchwil sy'n briodol i deitl gradd penodol.
PMBM06J Fundamentals of Biomedical Sciences 2

This module has been designed to provide students with the fundamental knowledge and principle concepts of biomedical science from a scientific and practice basis. The module will cover the following key topics across the life span: ¿ Human Anatomy and Physiology ¿ across the life span ¿ Cellular biology from structure to pathology ¿ Good laboratory practice and Sustainability ¿ Key principles of cell pathology, clinical biochemistry, clinical microbiology, clinical immunology, clinical genetics and haematology ¿ Clinical Pathology ¿ Quality Management
PMGM17 Dissertation Project

The module is for students to build on their previous knowledge, skills and experience by undertaking a laboratory based or suitable non-laboratory based project on a specific subject related to genomics.

Grantiau a Phrosiectau Allweddol

Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. 2017 - 2018

Ysgoloriaeth MSc a ariennir gan KESS2, with Dr. Ricardo Del Sol (SUMS) Dr. Alison Jack (Cultech Ltd) Dr. Sue Plummer (Cultech Ltd) , 35,000
Genome guided evaluation of CUL probiotic bacterial isolates. 2018

Ysgoloriaeth MSc a ariennir gan KESS2, with Dr. Ricardo Del Sol (SUMS) Dr. Alison Jack (Cultech) Dr. Daryn Michael (Cultech Ltd) , 52,000
Microbiome Characterization Guides the Development of Novel Pest Control Strategies: Lessons Derived From F. occidentalis Microbial Symbionts. 2018

Ysgoloriaeth MSc a ariennir gan KESS2, with Dr. Ricardo Del Sol (SUMS) Prof. Paul Dyson (SUMS) Dr. Maarten Stuiver (BASF) , 109,000
Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. (current) 2019

Ysgoloriaeth MSc a ariennir gan KESS2, with Dr. Ricardo Del Sol (SUMS) Dr. Daryn Michael (Cultech Ltd) Dr. Sue Plummer (Cultech Ltd) , 35,000
Genomic interrogation of Candida albicans with relation to reproductive health and fertility. 2019

, with Dr. Ricardo Del Sol

Dr Paul Facey

Cyfeiriad ebost

Twitter Account

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Goruchwyliaeth

A genome guided evalution of cadidate probiotics, from the Lactobacillus and Bifdobacterium genera. (dyfarnwyd 2022)

Investigating the potential for probiotic bacteria to be used as biotherapeutic interventions for colorectal cancer. (dyfarnwyd 2023)

Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. (dyfarnwyd 2024)

Modiwlau a Addysgir

PM-149 Genetics, Genomics & Evolution

PM-252 Molecular Evolution

PM-344 Capstone Project

PM-361C Biowybodeg: O ddilyniant i swyddogaeth

PM-400 Advanced Research Project A

PM-400C Prosiect Ymchwil Uwch A

PM-405 Advanced Research Project Dissertation

PM-405C Traethawd Hir Prosiect Ymchwil Uwch

PMBM06J Fundamentals of Biomedical Sciences 2

PMGM17 Dissertation Project

Grantiau a Phrosiectau Allweddol

Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. 2017 - 2018

Genome guided evaluation of CUL probiotic bacterial isolates. 2018

Microbiome Characterization Guides the Development of Novel Pest Control Strategies: Lessons Derived From F. occidentalis Microbial Symbionts. 2018

Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. (current) 2019

Genomic interrogation of Candida albicans with relation to reproductive health and fertility. 2019

Development of a multiplex PCR assay for detection and an organism specific live/dead enumeration method for bacteria included in complex probiotic products. (current) 2019