Dr Paula Row

Uwch-ddarlithydd, Biomedical Sciences

+44 (0) 1792 602789

p.e.row@abertawe.ac.uk

258
Llawr Cyntaf
Adeilad Grove
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Trosolwg

Mae Paula wedi bod yn aelod o'r tîm Biocemeg ers 2007. Mae ei hymchwil bresennol yn canolbwyntio ar weithgarwch gwrthfacterol olewau hanfodol a meddyginiaethau llysieuol a'r posibilrwydd o'u defnyddio i drin syndrom coluddyn llidus, y mae'n hysbys erbyn hyn fod newidiadau i facteria perfedd yn gysylltiedig ag ef. Mae hi'n aelod o'r tîm sy'n goruchwylio myfyriwr meddygaeth sy'n ymchwilio i'r defnydd o drawsblaniadau ysgarthol er mwyn trin llid briwiol y coluddyn. Enillodd Paula ei gradd gyntaf, sef BSc mewn Biocemeg gyda blwyddyn allanol, o Goleg y Brenin Llundain (gradd anrhydedd dosbarth cyntaf) ac roedd ei PhD a'i hymchwil ôl-ddoethurol i gyd yn ymwneud â chludo pilenni (sut cludir proteinau i'r lle cywir mewn celloedd). Mewnforio proteinau cloroplast oedd testun ei PhD o Adran Gwyddorau Planhigion Prifysgol Caergrawnt. Mae Paula yn cyflwyno, neu'n addysgu, nifer o fodiwlau biocemeg craidd.

Meysydd Arbenigedd

Biocemeg
Cludo pilenni, yn enwedig derbynyddion
Ubiquitin
Bioleg Celloedd Moleciwlaidd
Sail foleciwlaidd a chellog clefydau a therapiwteg
Gweithgarwch gwrthfacterol

Uchafbwyntiau Gyrfa

Prif Wobrau

Mehefin 2008 – Gwobr Cyfraniad Addysgu Prifysgol Abertawe
Hydref 1991 – Ysgoloriaeth Ymchwil Frank Smart, Adran Gwyddorau Planhigion Prifysgol Caergrawnt
Mehefin 1991 – Gwobr William Robson mewn Biocemeg, Coleg y Brenin Llundain

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Row, P., Jannoo, R., Xia, Z., Row, P., & Kanamarlapudi, V. (2023). Targeting of the Interleukin-13 Receptor (IL-13R)α2 Expressing Prostate Cancer by a Novel Hybrid Lytic Peptide. Biomolecules, 13(2), 356
https://doi.org/10.3390/biom13020356, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63097
http://dx.doi.org/10.3390/biom13020356
Wilkinson, T., Jenkins, G., Davies, A., Row, P., Hitchings, M., & Islam, S. (2018). Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study. BMJ Open
https://doi.org/10.1136/bmjopen-2018-021987, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45409
Thompson, A., Meah, D., Ahmed, N., Conniff-Jenkins, R., Chileshe, E., Phillips, C., Claypole, T., Forman, D., Row, P., Claypole, T., Phillips, C., & Forman, D. (2013). Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome. BMC Complementary and Alternative Medicine, 13(1), 338
https://doi.org/10.1186/1472-6882-13-338, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18384
http://www.biomedcentral.com/content/pdf/1472-6882-13-338.pdf
Bond, A., Row, P., Dudley, E., Dudley, E., & Row, P. (2011). Post-translation modification of proteins; methodologies and applications in plant sciences. Phytochemistry, 72(10), 975-996.
https://doi.org/10.1016/j.phytochem.2011.01.029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10603
Row, P., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., Clague, M., Sanderson, C., Urbe, S., & Row, P. (2007). The MIT Domain of UBPY Constitutes a CHMP Binding and Endosomal Localization Signal Required for Efficient Epidermal Growth Factor Receptor Degradation. Journal of Biological Chemistry, 282(42), 30929-30937.
https://doi.org/10.1074/jbc.M704009200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1511
McCullough, J., Urbé, S., Row, P., Prior, I., Welchman, R., Clague, M., & Row, P. (2006). Control of growth factor receptor dynamics by reversible ubiquitination. Biochemical Society Transactions, 34(5), 754
https://doi.org/10.1042/BST0340754, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18385
Row, P., Prior, I., McCullough, J., Clague, M., Urbé, S., & Row, P. (2006). The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation. Journal of Biological Chemistry, 281(18), 12618-12624.
https://doi.org/10.1074/jbc.M512615200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1512
McCullough, J., Row, P., Lorenzo, Ó., Doherty, M., Beynon, R., Clague, M., & Urbé, S. (2006). Activation of the Endosome-Associated Ubiquitin Isopeptidase AMSH by STAM, a Component of the Multivesicular Body-Sorting Machinery. Current Biology, 16(2), 160-165.
https://doi.org/10.1016/j.cub.2005.11.073, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18382
http://ac.els-cdn.com/S0960982205015241/1-s2.0-S0960982205015241-main.pdf?_tid=48af539c-38ef-11e4-949d-00000aab0f6c&acdnat=1410356289_96c0ae8c70550570797a00a792ca4c8b
Row, P., Clague, M., & Urbé, S. (2005). Growth factors induce differential phosphorylation profiles of the Hrs–STAM complex: a common node in signalling networks with signal-specific properties. Biochemical Journal, 389(3), 629
https://doi.org/10.1042/BJ20050067, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1513
Cook, N., Row, P., & Davidson, H. (2004). Lysosome Associated Membrane Protein 1 (Lamp1) Traffics Directly from the TGN to Early Endosomes. Traffic, 5(9), 685-699.
https://doi.org/10.1111/j.1600-0854.2004.00212.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18381
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0854.2004.00212.x/asset/j.1600-0854.2004.00212.x.pdf?v=1&t=hzwpbpou&s=b8b7d06384e9820167203022a49642432b43aa96
Urbe, S., Sachse, M., Row, P., Preisinger, C., Barr, F., Strous, G., Klumperman, J., & Clague, M. (2003). The UIM domain of Hrs couples receptor sorting to vesicle formation. Journal of Cell Science, 116(20), 4169-4179.
https://doi.org/10.1242/jcs.00723, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18377
http://jcs.biologists.org/content/116/20/4169.full.pdf
Row, P. & Gray, J. (2001). The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates. Journal of Experimental Botany, 52(354), 57-66.
https://doi.org/10.1093/jexbot/52.354.57, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18376
http://jxb.oxfordjournals.org/content/52/354/57.full.pdf
Row, P. & Gray, J. (2001). Chloroplast precursor proteins compete to form early import intermediates in isolated pea chloroplasts. Journal of Experimental Botany, 52(354), 47-56.
https://doi.org/10.1093/jexbot/52.354.47, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18375
http://jxb.oxfordjournals.org/content/52/354/47.full.pdf
Row, P., REAVES, B., DOMIN, J., LUZIO, J., & DAVIDSON, H. (2001). Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Biochemical Journal, 353(3), 655-661.
https://doi.org/10.1042/bj3530655, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18374
Reaves, B., Row, P., Bright, N., Luzio, J., & Davidson, H. (2000). Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies. Journal of Cell Science, 113, 4099-4108.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18373
http://jcs.biologists.org/content/113/22/4099.full.pdf
Gray, J. & Row, P. (1995). Protein translocation across chloroplast envelope membranes. Trends in Cell Biology, 5(6), 243-247.
https://doi.org/10.1016/S0962-8924(00)89018-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18372
http://www.sciencedirect.com/science/article/pii/S0962892400890182

Holl Ymchwil

Erthyglau Cylchgronau

Row, P., Jannoo, R., Xia, Z., Row, P., & Kanamarlapudi, V. (2023). Targeting of the Interleukin-13 Receptor (IL-13R)α2 Expressing Prostate Cancer by a Novel Hybrid Lytic Peptide. Biomolecules, 13(2), 356
https://doi.org/10.3390/biom13020356, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63097
http://dx.doi.org/10.3390/biom13020356
Wilkinson, T., Jenkins, G., Davies, A., Row, P., Hitchings, M., & Islam, S. (2018). Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study. BMJ Open
https://doi.org/10.1136/bmjopen-2018-021987, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45409
Thompson, A., Meah, D., Ahmed, N., Conniff-Jenkins, R., Chileshe, E., Phillips, C., Claypole, T., Forman, D., Row, P., Claypole, T., Phillips, C., & Forman, D. (2013). Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome. BMC Complementary and Alternative Medicine, 13(1), 338
https://doi.org/10.1186/1472-6882-13-338, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18384
http://www.biomedcentral.com/content/pdf/1472-6882-13-338.pdf
Bond, A., Row, P., Dudley, E., Dudley, E., & Row, P. (2011). Post-translation modification of proteins; methodologies and applications in plant sciences. Phytochemistry, 72(10), 975-996.
https://doi.org/10.1016/j.phytochem.2011.01.029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10603
Row, P., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., Clague, M., Sanderson, C., Urbe, S., & Row, P. (2007). The MIT Domain of UBPY Constitutes a CHMP Binding and Endosomal Localization Signal Required for Efficient Epidermal Growth Factor Receptor Degradation. Journal of Biological Chemistry, 282(42), 30929-30937.
https://doi.org/10.1074/jbc.M704009200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1511
McCullough, J., Urbé, S., Row, P., Prior, I., Welchman, R., Clague, M., & Row, P. (2006). Control of growth factor receptor dynamics by reversible ubiquitination. Biochemical Society Transactions, 34(5), 754
https://doi.org/10.1042/BST0340754, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18385
Row, P., Prior, I., McCullough, J., Clague, M., Urbé, S., & Row, P. (2006). The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation. Journal of Biological Chemistry, 281(18), 12618-12624.
https://doi.org/10.1074/jbc.M512615200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1512
McCullough, J., Row, P., Lorenzo, Ó., Doherty, M., Beynon, R., Clague, M., & Urbé, S. (2006). Activation of the Endosome-Associated Ubiquitin Isopeptidase AMSH by STAM, a Component of the Multivesicular Body-Sorting Machinery. Current Biology, 16(2), 160-165.
https://doi.org/10.1016/j.cub.2005.11.073, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18382
http://ac.els-cdn.com/S0960982205015241/1-s2.0-S0960982205015241-main.pdf?_tid=48af539c-38ef-11e4-949d-00000aab0f6c&acdnat=1410356289_96c0ae8c70550570797a00a792ca4c8b
Row, P., Clague, M., & Urbé, S. (2005). Growth factors induce differential phosphorylation profiles of the Hrs–STAM complex: a common node in signalling networks with signal-specific properties. Biochemical Journal, 389(3), 629
https://doi.org/10.1042/BJ20050067, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1513
Cook, N., Row, P., & Davidson, H. (2004). Lysosome Associated Membrane Protein 1 (Lamp1) Traffics Directly from the TGN to Early Endosomes. Traffic, 5(9), 685-699.
https://doi.org/10.1111/j.1600-0854.2004.00212.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18381
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0854.2004.00212.x/asset/j.1600-0854.2004.00212.x.pdf?v=1&t=hzwpbpou&s=b8b7d06384e9820167203022a49642432b43aa96
Urbe, S., Sachse, M., Row, P., Preisinger, C., Barr, F., Strous, G., Klumperman, J., & Clague, M. (2003). The UIM domain of Hrs couples receptor sorting to vesicle formation. Journal of Cell Science, 116(20), 4169-4179.
https://doi.org/10.1242/jcs.00723, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18377
http://jcs.biologists.org/content/116/20/4169.full.pdf
Row, P. & Gray, J. (2001). The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates. Journal of Experimental Botany, 52(354), 57-66.
https://doi.org/10.1093/jexbot/52.354.57, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18376
http://jxb.oxfordjournals.org/content/52/354/57.full.pdf
Row, P. & Gray, J. (2001). Chloroplast precursor proteins compete to form early import intermediates in isolated pea chloroplasts. Journal of Experimental Botany, 52(354), 47-56.
https://doi.org/10.1093/jexbot/52.354.47, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18375
http://jxb.oxfordjournals.org/content/52/354/47.full.pdf
Row, P., REAVES, B., DOMIN, J., LUZIO, J., & DAVIDSON, H. (2001). Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Biochemical Journal, 353(3), 655-661.
https://doi.org/10.1042/bj3530655, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18374
Reaves, B., Row, P., Bright, N., Luzio, J., & Davidson, H. (2000). Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies. Journal of Cell Science, 113, 4099-4108.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18373
http://jcs.biologists.org/content/113/22/4099.full.pdf
Gray, J. & Row, P. (1995). Protein translocation across chloroplast envelope membranes. Trends in Cell Biology, 5(6), 243-247.
https://doi.org/10.1016/S0962-8924(00)89018-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18372
http://www.sciencedirect.com/science/article/pii/S0962892400890182

Goruchwyliaeth

The microbiota in ulcerative colitis: a feasability study for a clinical trial of faecal microbiota transplant in selected cases (dyfarnwyd 2022)

MD

Goruchwyliwr arall: Prof Angharad Davies

Modiwlau a Addysgir

PM-127 Energy and Metabolism: The Reactions of Life

This module provides an introduction to bioenergetics and the chemical structure of carbohydrates as well as a discussion of the central metabolic pathways by which energy from food is used to fuel the synthesis of the energy currency molecule ATP (with particular attention to glycolysis, the citric acid cycle and oxidative phosphorylation). The concept of tissue and organ specificity is introduced, and finally the role of the hormones insulin, glucagon, epinephrine, growth hormone, thyroid hormone and leptin in controlling these pathways and producing effects on the body is considered.
PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-243 Clinical Biochemistry & Physiology

The module begins with a discussion of selected metabolic disorders of carbohydrate metabolism and their pathological consequences with particular emphasis on diabetes mellitus. The molecular mechanisms underlying polycystic ovarian syndrome are then considered. Next, there will be a discussion of the analytical tests used by the NHS to diagnose and monitor diseases such as diabetes (for instance the glycated haemoglobin or Hba1c test) how the test(s) can be affected by haemoglobinopathies and the length of time that has elapsed since someone has taken their medication. Finally the module reviews mechanisms of protein transport and their relevance to storage diseases.
PM-245 Metabolic Regulation: Enzymes & Signal Transduction

This module reviews the basic elements of enzyme kinetics, including their mechanism and inhibition. The control of enzyme function by allosteric mechanisms is considered together with an appreciation of the significance of sigmoid kinetics. An overview of coenzymes and (metal) co-factors in enzyme function is given together with a description of the role played by vitamins in co-enzyme production.
PM-277 Techniques in Molecular Biology

The module will provide a sound theoretical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.
PM-277C Technegau Bioleg Foleciwlaidd

Bydd y modiwl yn darparu sylfaen ddamcaniaethol gadarn ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoddir pwyslais arbennig ar dechnoleg ail-gyfuno DNA, dilyniannu¿r genhedlaeth nesaf, trawsgrifiadomeg, proteinomeg a sbectrometreg màs.
PM-280 Skills for Researchers

The modern scientist graduate is expected to have gained extensive laboratory-based experience and this is certainly essential for any student intent on pursuing a research-based career. Skills for Researchers provides students with the opportunity to acquire the core skills to be able to conduct, analyse, interpret and present scientific experiments. A proportion of the module will be spent in the laboratory gaining hands-on experience. Skills acquired in this module will form the basis for future experimental work, including the final year project. Students will have the opportunity to provide feedback to peers and engage with a variety of online learning materials.
PM-319 Membranes and Energy Transduction

An appreciation of the molecular architecture of energy-conserving membranes is provided together with an understanding of the molecular mechanisms involved in energy transduction. The course also provides an understanding of the structure and properties of membranes, the lipids contained within them and the techniques used to study them.
PM-331 Membrane Trafficking

The module provides an understanding of the subcellular organelles, the regulation of their biosynthesis and how impairment of this process leads to disease.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.

Hanes Gyrfa

Darlithydd / Uwch Ddarlithydd mewn Biocemeg, Prifysgol Abertawe

2007 - Presennol
Cydymaith Ymchwil Ôl-ddoethurol , Prifysgol Lerpwl

Hydref 2002 - Medi 2006
Cydymaith Ymchwil Ôl-ddoethurol , Prifysgol Caergrawnt

Awst 1996 - Gorffennaf 2002
Myfyriwr PhD, Prifysgol Caergrawnt

Hydref 1991 - Gorffennaf 1996
Myfyriwr yn darllen am BSc mewn Biocemeg gyda blwyddyn allanol , Coleg y Brenin Llundain

Hydref 1987 - Gorffennaf 1991
Blwyddyn allanol fel myfyriwr , Blwyddyn allanol fel myfyriwr

1989 - 1990

Swyddi Cysylltiedig

Cydlynydd Anabledd , Prifysgol Abertawe

2013 - Presennol
Cydlynydd Anabledd ar ran myfyrwyr ymchwil Ysgol Feddygaeth Prif, Prifysgol Abertawe

2013 - 2018
Arweinydd Academi Dysgu ac Addysgu Abertawe yn Ysgol Feddygaeth , Prifysgol Abertawe

2013 - Presennol
Arweinydd Academaidd (SAILS) , Prifysgol Abertawe

2017 - Presennol
Aelod o Bwyllgor Ymchwil Ysgol Feddygaeth Prifysgol Abertawe , Prifysgol Abertawe

2016 - Presennol
Aelod (Bwrdd Addysgu) , Prifysgol Abertawe

2007 - Presennol
Aelod (Pwyllgor Dysgu ac Addysgu Ysgol Feddygaeth Prifysgol Aber, Prifysgol Abertawe

2013 - Presennol

Dr Paula Row

Rhif ffôn

Cyfeiriad ebost

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Goruchwyliaeth

The microbiota in ulcerative colitis: a feasability study for a clinical trial of faecal microbiota transplant in selected cases (dyfarnwyd 2022)

Modiwlau a Addysgir

PM-127 Energy and Metabolism: The Reactions of Life

PM-130 Fundamental Research Skills

PM-243 Clinical Biochemistry & Physiology

PM-245 Metabolic Regulation: Enzymes & Signal Transduction

PM-277 Techniques in Molecular Biology

PM-277C Technegau Bioleg Foleciwlaidd

PM-280 Skills for Researchers

PM-319 Membranes and Energy Transduction

PM-331 Membrane Trafficking

PM-344 Capstone Project

Hanes Gyrfa

Darlithydd / Uwch Ddarlithydd mewn Biocemeg, Prifysgol Abertawe

Cydymaith Ymchwil Ôl-ddoethurol , Prifysgol Lerpwl

Cydymaith Ymchwil Ôl-ddoethurol , Prifysgol Caergrawnt

Myfyriwr PhD, Prifysgol Caergrawnt

Myfyriwr yn darllen am BSc mewn Biocemeg gyda blwyddyn allanol , Coleg y Brenin Llundain

Blwyddyn allanol fel myfyriwr , Blwyddyn allanol fel myfyriwr

Swyddi Cysylltiedig

Cydlynydd Anabledd , Prifysgol Abertawe

Cydlynydd Anabledd ar ran myfyrwyr ymchwil Ysgol Feddygaeth Prif, Prifysgol Abertawe

Arweinydd Academi Dysgu ac Addysgu Abertawe yn Ysgol Feddygaeth , Prifysgol Abertawe

Arweinydd Academaidd (SAILS) , Prifysgol Abertawe

Aelod o Bwyllgor Ymchwil Ysgol Feddygaeth Prifysgol Abertawe , Prifysgol Abertawe

Aelod (Bwrdd Addysgu) , Prifysgol Abertawe

Aelod (Pwyllgor Dysgu ac Addysgu Ysgol Feddygaeth Prifysgol Aber, Prifysgol Abertawe