Professor Christopher George

Professor, Biomedical Sciences

christopher.george@swansea.ac.uk

Basic Welsh Speaker

Academic Office - 143
First Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0001-9852-1135

About

Chris is Professor of Molecular Cardiology in Swansea University Medical School. His group uses molecular and cellular tools combined with network theory to explore the links between calcium signaling, cellular behavior and the early events leading to the destruction of normal heart rhythm (arrhythmia).

Chris’ primary research focus is on using experimental and clinical data to predict how heart cells, the engine of every heartbeat, respond to genetic mutations and to drugs. His work will improve therapeutic approaches for tackling genetic and acquired heart disease. His research is funded by the British Heart Foundation, BBSRC, Wellcome Trust, MRC, Health and Care Research Wales and the European Union.

Chris is Senior Editor at the British Journal of Pharmacology looking after the Journal’s cardiovascular portfolio. He is also a member of the editorial board of Cardiovascular Research, Frontiers in Physiology and Artery Research.

He is on the Board of the National Centre for Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and is Chair of its Grant Assessment Panel.

In 2020, Chris became the Chair of the National Cardiovascular Network for Wales (NCN), a partnership between Welsh Government and the British Heart Foundation.

Any spare time he has is completely dominated by the tapestry of family life. In 1973, Chris began a lifelong love-affair with Liverpool Football Club and he plays a variety of guitars less well than anyone he lives with. He is a huge fan of the great outdoors, walking and cycling.

Areas Of Expertise

Mechanisms of cardiac arrhythmias
Calcium signalling
Stem cells
Molecular biology
Cell biology
Systems biology
Drug screening technologies

Publications

Research Highlights

Panettieri, R., Stanford, S., Alexander, S., Cirino, G., George, C., Insel, P., Kendall, D., Ji, Y., Patel, H., Sobey, C., Stefanska, B., Stephens, G., Teixeira, M., Vergnolle, N., Ferdinandy, P., & Ahluwalia, A. (n.d.) BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. British Journal of Pharmacology, 180(12)
https://doi.org/10.1111/bph.16089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63278
http://dx.doi.org/10.1111/bph.16089
Stanford, S., Alexander, S., Cirino, G., George, C., Insel, P., Kendall, D., Ji, Y., Panettieri, R., Patel, H., Sobey, C., Stefanska, B., Stephens, G., Teixeira, M., Vergnolle, N., Ferdinandy, P., & Ahluwalia, A. (2023). Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology. British Journal of Pharmacology, 180(9), 1191-1196.
https://doi.org/10.1111/bph.16049, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63277
http://dx.doi.org/10.1111/bph.16049
Williams, C., Hather, C., Conteh, J., Zhang, J., Popa, R., Owen, A., Jonas, C., Choi, H., Daniel, R., Lloyd, D., Porch, A., & George, C. (2023). Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. Biochemical and Biophysical Research Communications, 661, 89-98.
https://doi.org/10.1016/j.bbrc.2023.04.038, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63176
http://dx.doi.org/10.1016/j.bbrc.2023.04.038
Ingrande, J., Patel, H., Kendall, D., Stefanska, B., Alexander, S., Bakhle, M., Cirino, G., Docherty, J., George, C., Insel, P., Ji, Y., King, B., Lilley, E., Panettieri, R., Ramage, A., Sobey, C., Stanford, S., Stephens, G., Teixeira, M...., & Ahluwalia, A. (2023). Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. British Journal of Pharmacology, 180(3), 255-263.
https://doi.org/10.1111/bph.15992, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62193
Curtis, M., Alexander, S., Cirino, G., George, C., Kendall, D., Insel, P., Izzo, A., Ji, Y., Panettieri, R., Patel, H., Sobey, C., Stanford, S., Stanley, P., Stefanska, B., Stephens, G., Teixeira, M., Vergnolle, N., & Ahluwalia, A. (2022). Planning experiments: Updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology, 179(15), 3907-3913.
https://doi.org/10.1111/bph.15868, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60174
Sobey, C., Drummond, G., & George, C. (2022). How good are our models of cardiovascular disease?. British Journal of Pharmacology, 179(5), 745-747.
https://doi.org/10.1111/bph.15761, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59393
Hamilton, S., Terentyeva, R., Bogdanov, V., Kim, T., Perger, F., Yan, J., Ai, X., Carnes, C., Belevych, A., George, C., Davis, J., Gyorke, S., Choi, B., & Terentyev, D. (2022). Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia. Circulation Research, 130(5), 711-724.
https://doi.org/10.1161/circresaha.121.320531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59209
Richardson, E., Troczka, B., Gutbrod, O., Ebbinghaus-Kintscher, U., Williamson, M., George, C., Nauen, R., & Davies, T. (2021). Chimeric Investigations into the Diamide Binding Site on the Lepidopteran Ryanodine Receptor. International Journal of Molecular Sciences, 22(23), 13033
https://doi.org/10.3390/ijms222313033, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58894
Richardson, E., Homem, R., Troczka, B., George, C., Ebbinghaus‐Kintscher, U., Williamson, M., Nauen, R., & Davies, T. (2022). Diamide insecticide resistance in transgenic Drosophila and Sf9-cells expressing a full-length diamondback moth ryanodine receptor carrying an I4790M mutation. Pest Management Science, 78(3), 869-880.
https://doi.org/10.1002/ps.6730, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58748
Hamilton, S., Terentyeva, R., Kim, T., Martin, B., Bogdanov, V., Belevych, A., George, C., Gyorke, S., Choi, B., Davis, J., & Terentyev, D. (2021). The Sarcoplasmic Reticulum Oxidoreductase System Modulates Luminal Ca2+ Regulation of the Ryanodine Receptor in Cardiac Disease. Biophysical Journal, 120(3), 239a
https://doi.org/10.1016/j.bpj.2020.11.1575, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58712
George, C., Alexander, S., Cirino, G., Insel, P., Izzo, A., Ji, Y., Kendall, D., Panettieri, R., Patel, H., Sobey, C., Stanford, S., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2021). Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). British Journal of Pharmacology, 178(18), 3605-3610.
https://doi.org/10.1111/bph.15589, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58711
Bannister, M., MacLeod, K., & George, C. (2022). Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor. British Journal of Pharmacology, 179(11), 2558-2563.
https://doi.org/10.1111/bph.15718, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58568
Fenton, D., Phillips, D., Maddison, A., George, C., Ryves, J., & Jones, H. (2020). Cupid, a cell permeable peptide derived from amoeba, capable of delivering GFP into a diverse range of species. Scientific Reports, 10(1)
https://doi.org/10.1038/s41598-020-70532-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54856
George, C., Alexander, S., Cirino, G., Docherty, J., Hoyer, D., Insel, P., Izzo, A., Ji, Y., Panettieri, R., Sobey, C., Stanford, S., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2019). The BJP expects authors to share data. British Journal of Pharmacology, 176(24), 4595-4598.
https://doi.org/10.1111/bph.14907, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53360
Izzo, A., Teixeira, M., Alexander, S., Cirino, G., Docherty, J., George, C., Insel, P., Ji, Y., Kendall, D., Panattieri, R., Sobey, C., Stanford, S., Stefanska, B., Stephens, G., & Ahluwalia, A. (2020). A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. British Journal of Pharmacology, 177(10), 2169-2178.
https://doi.org/10.1111/bph.15054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54011
Lilley, E., Stanford, S., Kendall, D., Alexander, S., Cirino, G., Docherty, J., George, C., Insel, P., Izzo, A., Ji, Y., Panettieri, R., Sobey, C., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2020). ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. British Journal of Pharmacology, 177(16), 3611-3616.
https://doi.org/10.1111/bph.15178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54748
Jones, A., Edwards, D., Cummins, M., Williams, A., & George, C. (2016). A Systemized Approach to Investigate Ca2+ Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes. Frontiers in Cell and Developmental Biology, 3
https://doi.org/10.3389/fcell.2015.00089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35904
George, C., Jundi, H., Thomas, N., Scoote, M., Walters, N., Williams, A., Lai, F., George, C., Thomas, N., & Williams, A. (2004). Ryanodine Receptor Regulation by Intramolecular Interaction between Cytoplasmic and Transmembrane Domains. Molecular Biology of the Cell, 15(6), 2627-2638.
https://doi.org/10.1091/mbc.E03-09-0688, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35323
http://www.scopus.com/inward/record.url?eid=2-s2.0-2542448132&partnerID=MN8TOARS
Thomas, N., George, C., Lai, F., George, C., & Thomas, N. (2004). Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovascular Research, 64(1), 52-60.
https://doi.org/10.1016/j.cardiores.2004.06.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35324
http://europepmc.org/abstract/med/15364613
Thomas, N., Lai, F., George, C., George, C., & Thomas, N. (2005). Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochemical and Biophysical Research Communications, 331(1), 231-238.
https://doi.org/10.1016/j.bbrc.2005.02.194, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35325
http://www.scopus.com/inward/record.url?eid=2-s2.0-17444376389&partnerID=MN8TOARS
George, C., Thomas, N., Lai, F., George, C., & Thomas, N. (2005). Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiology, 1(4), 531-541.
https://doi.org/10.2217/14796678.1.4.531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35326
http://europepmc.org/abstract/med/19804154
Thomas, N., George, C., Lai, F., George, C., & Thomas, N. (2006). Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?. Biochemical Society Transactions, 34(5), 913-918.
https://doi.org/10.1042/BST0340913, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35327
http://www.scopus.com/inward/record.url?eid=2-s2.0-33751292623&partnerID=MN8TOARS
George, C., Jundi, H., Walters, N., Thomas, N., West, R., Lai, F., George, C., & Thomas, N. (2006). Arrhythmogenic Mutation-Linked Defects in Ryanodine Receptor Autoregulation Reveal a Novel Mechanism of Ca2+ Release Channel Dysfunction. Circulation Research, 98(1), 88-97.
https://doi.org/10.1161/01.RES.0000199296.70534.7c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35328
http://www.scopus.com/inward/record.url?eid=2-s2.0-33644837101&partnerID=MN8TOARS
George, C., Jundi, H., Thomas, N., Fry, D., Lai, F., George, C., & Thomas, N. (2007). Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies. Journal of Molecular and Cellular Cardiology, 42(1), 34-50.
https://doi.org/10.1016/j.yjmcc.2006.08.115, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35329
http://www.scopus.com/inward/record.url?eid=2-s2.0-33845611191&partnerID=MN8TOARS
Thomas, N., George, C., Williams, A., Lai, F., George, C., Thomas, N., & Williams, A. (2007). Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochemical Society Transactions, 35(5), 946-951.
https://doi.org/10.1042/BST0350946, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35330
http://www.scopus.com/inward/record.url?eid=2-s2.0-36749067461&partnerID=MN8TOARS
George, C., Rogers, S., Bertrand, B., Tunwell, R., Thomas, N., Steele, D., Cox, E., Pepper, C., Hazeel, C., Claycomb, W., Lai, F., George, C., & Thomas, N. (2007). Alternative Splicing of Ryanodine Receptors Modulates Cardiomyocyte Ca2+ Signaling and Susceptibility to Apoptosis. Circulation Research, 100(6), 874-883.
https://doi.org/10.1161/01.RES.0000260804.77807.cf, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35331
http://www.scopus.com/inward/record.url?eid=2-s2.0-34147174284&partnerID=MN8TOARS
Boileau, E., George, C., Parthimos, D., Mitchell, A., Aziz, S., & Nithiarasu, P. (2015). Synergy Between Intercellular Communication and Intracellular Ca2+ Handling in Arrhythmogenesis. Annals of Biomedical Engineering, 43(7), 1614-1625.
https://doi.org/10.1007/s10439-014-1243-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21238
http://link.springer.com/article/10.1007/s10439-014-1243-x
Williams, A., Bannister, M., Thomas, N., Sikkel, M., Mukherjee, S., Maxwell, C., MacLeod, K., George, C., Bannister, M., George, C., Thomas, N., Mukherjee, S., & Williams, A. (2016). Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology, 594(21), 6431-6432.
https://doi.org/10.1113/jp272497, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34319
http://europepmc.org/abstract/med/27800620
George, C., Mitchell, A., Preece, R., Bannister, M., Yousef, Z., Bannister, M., & George, C. (2016). Pleiotropic mechanisms of action of perhexiline in heart failure. Expert Opinion on Therapeutic Patents, 26(9), 1049-1059.
https://doi.org/10.1080/13543776.2016.1211111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34320
Bannister, M., Alvarez-Laviada, A., Thomas, N., Mason, S., Coleman, S., du, P., Moran, A., Neill-Hall, D., Osman, H., Bagley, M., MacLeod, K., George, C., Williams, A., Bannister, M., George, C., Thomas, N., & Williams, A. (2016). Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology, 173(15), 2446-2459.
https://doi.org/10.1111/bph.13521, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34321
http://europepmc.org/abstract/med/27237957
Docherty, J., Stanford, S., Panattieri, R., Alexander, S., Cirino, G., George, C., Hoyer, D., Izzo, A., Ji, Y., Lilley, E., Sobey, C., Stanley, P., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2019). Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable. British Journal of Pharmacology, 176(21)
https://doi.org/10.1111/bph.14761, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52057
Williams, C. & George, C. (2019). Connect and Conquer: Collectivized Behavior of Mitochondria and Bacteria. Frontiers in Physiology, 10
https://doi.org/10.3389/fphys.2019.00340, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49863
https://www.frontiersin.org/articles/10.3389/fphys.2019.00340/full
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2018). Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?. Journal of Cell Science, 131(15), jcs210443
https://doi.org/10.1242/jcs.210443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41186
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & George, C. (2018). Association of Cardiac Myosin Binding Protein-C with the Ryanodine Receptor-Ca 2+ Release Channel: Putative Retrograde Regulation?. Biophysical Journal, 114(3), 621a
https://doi.org/10.1016/j.bpj.2017.11.3359, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40608
Gintant, G. & George, C. (2018). Introduction to biological complexity as a missing link in drug discovery. Expert Opinion on Drug Discovery, 13(8), 753-763.
https://doi.org/10.1080/17460441.2018.1480608, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40284
Curtis, M., Alexander, S., Cirino, G., Docherty, J., George, C., Giembycz, M., Hoyer, D., Insel, P., Izzo, A., Ji, Y., MacEwan, D., Sobey, C., Stanford, S., Teixeira, M., Wonnacott, S., & Ahluwalia, A. (2018). Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. British Journal of Pharmacology, 175(7), 987-993.
https://doi.org/10.1111/bph.14153, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39095
Alexander, S., Roberts, R., Broughton, B., Sobey, C., George, C., Stanford, S., Cirino, G., Docherty, J., Giembycz, M., Hoyer, D., Insel, P., Izzo, A., Ji, Y., MacEwan, D., Mangum, J., Wonnacott, S., & Ahluwalia, A. (2018). Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. British Journal of Pharmacology, 175(3), 407-411.
https://doi.org/10.1111/bph.14112, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38321
Williams, A., Thomas, N., & George, C. (2018). The ryanodine receptor: advances in structure and organization. Current Opinion in Physiology, 1, 1-6.
https://doi.org/10.1016/j.cophys.2017.10.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37297
George, C. & Edwards, D. (n.d.) Decoding Ca2+ Signals as a Non-electrophysiological Method for Assessing Drug Toxicity in Stem Cell-Derived Cardiomyocytes. Stem Cell-Derived Models in Toxicology (pp. 173-190). Humana Press
https://doi.org/10.1007/978-1-4939-6661-5_9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35382
Benson, M., Tinsley, C., Waite, A., Carlisle, F., Sweet, S., Ehler, E., George, C., Lai, F., Martin-Rendon, E., & Blake, D. (2017). Ryanodine receptors are part of the myospryn complex in cardiac muscle. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-06395-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35346
George, C., Stanford, S., Alexander, S., Cirino, G., Docherty, J., Giembycz, M., Hoyer, D., Insel, P., Izzo, A., Ji, Y., MacEwan, D., Sobey, C., Wonnacott, S., & Ahluwalia, A. (2017). Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. British Journal of Pharmacology, 174(17), 2801-2804.
https://doi.org/10.1111/bph.13925, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35322
Dhanjal, T., Lellouche, N., Ruhland, C., Abehsira, G., Edwards, D., Dubois-Randé, J., Moschonas, K., Teiger, E., Williams, A., & George, C. (2017). Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart. JACC: Clinical Electrophysiology, 3(7), 703-714.
https://doi.org/10.1016/j.jacep.2016.11.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34835
George, C. (2016). Effect of flecainide derivatives on sarcoplasmic reticulum Ca2+ release confirms a lack of direct action on the cardiac ryanodine receptor. In Biophysical JournalThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35720
George, C. (2016). Increased myofibroblast densities are specific to critical isthmus sites in post-infarct re-entrant ventricular tachycardia. In Heart Rhythm SocietyHeart Rhythm Society, San Francisco, May 2016..
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35756
George, C. (2016). LAVA sites are histologically closely related to critical isthmus sites in post-infarct ventricular tachycardia. In Heart Rhythm Society
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35757
George, C. (2015). Cellular characterisation of stromal cell and cardiomyocyte coupling at the critical isthmus in an in vivo swine model of post-infarction re-entrant ventricular tachycardia. In Journal of Investigative Cardiac Electrophysiology
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35758
George, C. (2015). The mechanism of flecainide action in catecholaminergic polymorphic ventricular tachycardia does not involve a direct effect on the ryanodine receptor. In Proceedings of The Physiological SocietyThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35721
George, C. (2015). Fundamental gating defects of sudden cardiac death-linked mutant cardiac ryanodine receptors determine Ca2+ release dynamics in cells. In Proceedings of The Physiological SocietyThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35722
Bannister, M., Thomas, N., Sikkel, M., Mukherjee, S., Maxwell, C., MacLeod, K., George, C., Williams, A., Bannister, M., George, C., Thomas, N., Mukherjee, S., & Williams, A. (2015). The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2. Circulation Research, 116(8), 1324-1335.
https://doi.org/10.1161/CIRCRESAHA.116.305347, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34834
Lewis, K., Silvester, N., Barberini-Jammaers, S., Mason, S., Marsh, S., Lipka, M., George, C., & George, C. (2015). A New System for Profiling Drug-Induced Calcium Signal Perturbation in Human Embryonic Stem Cell–Derived Cardiomyocytes. Journal of Biomolecular Screening, 20(3), 330-340.
https://doi.org/10.1177/1087057114557232, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35378
http://www.scopus.com/inward/record.url?eid=2-s2.0-84923327914&partnerID=MN8TOARS
George, C. (2014). Predictive Drug Toxicity Profiling using a New Mode of Calcium Signal Analysis in Human Es-Derived Cardiomyocytes. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35724
George, C. (2014). The Metabolic Modulator Perhexiline Induces Calcium-Cycling Dysfunction and Apoptosis in Cardiomyocyte Syncytia. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35725
George, C. (2013). Manipulating RyR2 Ca2+ Signalling in Cardiomyocyte Networks using Morpholino Oligonucleotides. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35739
George, C. (2013). An Assessment of Calcium Handling and Cardiovascular Drug-Profiling in Cytiva Embryonic Stem-Cell Derived Cardiomyocytes. In Biophys JElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35740
George, C. (2013). Exploring the Link between Ca2+ Signalling and ATP Dynamics in Cardiomyocyte Dysfunction. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35741
George, C. (2012). What really causes arrhythmias in heart failure?. British Society for Heart Failure, Supplement, 18
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35389
Viero, C., Thomas, N., Euden, J., Mason, S., George, C., & Williams, A. (2012). Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level. Calcium Signaling (pp. 183-215).
https://doi.org/10.1007/978-94-007-2888-2_8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35375
http://www.scopus.com/inward/record.url?eid=2-s2.0-84859891796&partnerID=MN8TOARS
George, C., Parthimos, D., Silvester, N., & George, C. (2012). A network-oriented perspective on cardiac calcium signaling. AJP: Cell Physiology, 303(9), C897-C910.
https://doi.org/10.1152/ajpcell.00388.2011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35376
http://www.scopus.com/inward/record.url?eid=2-s2.0-84868322954&partnerID=MN8TOARS
Silvester, N., George, C., & George, C. (2011). Searching for new cardiovascular drugs: towards improved systems for drug screening?. Expert Opinion on Drug Discovery, 6(11), 1155-1170.
https://doi.org/10.1517/17460441.2011.625652, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35373
http://www.scopus.com/inward/record.url?eid=2-s2.0-80755130608&partnerID=MN8TOARS
Phillips, S., Yu, Y., Rossbach, A., Nomikos, M., Vassilakopoulou, V., Livaniou, E., Cumbes, B., Lai, F., George, C., Swann, K., Cumbes, B., & George, C. (2011). Divergent effect of mammalian PLCζ in generating Ca2+oscillations in somatic cells compared with eggs. Biochemical Journal, 438(3), 545-553.
https://doi.org/10.1042/BJ20101581, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35374
http://www.scopus.com/inward/record.url?eid=2-s2.0-80052162953&partnerID=MN8TOARS
George, C. (2011). Ouabain is a Pharmacomimic of Mutant RyR2 Ca2+ Release Dysfunction but is not a Serum-Borne Trigger of CPVT. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35727
George, C. (2011). Trans Complementation with the Common G1885E Polymorphism Attenuates Mutant RyR2 L433P Channel Dysfunction. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35748
George, C. (2011). Targeted Inhibition of Connexin 43 Hemichannels Blunts Ca 2+-Induced Intercellular Dyssynchrony and ATP Efflux in Hl-1 Cardiomyocyte Syncitia. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35749
George, C. (2010). Method and system for analyzing calcium transients in coupled cells
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35752
George, C. (2010). Biophysical and Cellular Characterisation of Alternatively Spliced Isoforms of the Human Cardiac Ryanodine Receptor (RyR2). In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35744
George, C. (2010). Adaptive Retuning of Small Ca2+ Fluxes in Cardiomyocyte Syncytia Predicts the Response To Pro-Arrhythmic Stimuli. In Biophys J
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35746
Eisner, D., George, C., Smith, G., Trafford, A., Venetucci, L., & George, C. (2010). How does CaMKII phosphorylation of the cardiac ryanodine receptor contribute to inotropy?. Proceedings of the National Academy of Sciences, 107(31), E123-E123.
https://doi.org/10.1073/pnas.1008809107, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35372
http://www.scopus.com/inward/record.url?eid=2-s2.0-77956375917&partnerID=MN8TOARS
Raby, A., Le Bouder, E., Colmont, C., Davies, J., Richards, P., Coles, B., George, C., Jones, S., Brennan, P., Topley, N., Labéta, M., & George, C. (2009). Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering. The Journal of Immunology, 183(1), 506-517.
https://doi.org/10.4049/jimmunol.0802909, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35371
http://www.scopus.com/inward/record.url?eid=2-s2.0-68949110135&partnerID=MN8TOARS
George, C. (2009). Investigating the Ca 2+-cycling basis of rhythmicity and synchronicity in coupled cardiomyocyte monolayers. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35742
George, C. (2009). Decoding The Molecular Basis Of Anti-Apoptotic Cardiac Ca 2+ Signalling Via Human RyR2 Splice Variants. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35743
George, C. (2009). An L433P Arrhythmia-linked Mutation In RyR2 Uncouples Agonist-evoked Ca 2+ Release From Homeostatic Ca 2+ Cycling. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35750
George, C. (2009). Targeted Stabilisation Of The RyR2 I-Domain Restores Ca 2+ Handling And Intercellular Synchrony In Ouabain-disrupted Cardiac Cell Monolayers. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35751
George, C. (2009). A G1885E RyR2 polymorphism modulates the caffeine sensitivity of an arrhythmia-linked mutation. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35754
George, C. (2008). Evidence for serca and BK Ca activation in BNP protection of reperfused myocardium. Journal of Molecular and Cellular Cardiology, 44
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35753
George, C. (2008). Mutation-linked instability underlies RyR2 channel hypersensitivity to serum-borne factors. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35759
George, C. (2008). SALVO- a new analytical platform for decoding intracellular Ca2+ fluxes and evaluating anti-arrhythmic compounds. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35760
George, C. (2008). Suppression of arrhythmogenic Ca2+ fluxes in cardiac cells using fragments of human RyR2. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35761
George, C. (2008). Modulating intracellular Ca2+ signalling using recombinant fragments of the human cardiac ryanodine receptor (RyR2)
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35734
George, C. & George, C. (2008). Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?. Cardiovascular Research, 77(2), 302-314.
https://doi.org/10.1093/cvr/cvm006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35368
http://www.scopus.com/inward/record.url?eid=2-s2.0-38849149701&partnerID=MN8TOARS
George, C., Barberini-Jammaers, S., Muller, C., & George, C. (2008). Refocussing therapeutic strategies for cardiac arrhythmias: defining viable molecular targets to restore cardiac ion flux. Expert Opinion on Therapeutic Patents, 18(1), 1-19.
https://doi.org/10.1517/13543776.18.1.1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35369
http://www.scopus.com/inward/record.url?eid=2-s2.0-39749193540&partnerID=MN8TOARS
George, C. & George, C. (2008). Genetic polymorphisms in β1 and β2 adrenergic receptors: Variations without a theme?. Heart Rhythm, 5(6), 822-825.
https://doi.org/10.1016/j.hrthm.2008.03.034, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35370
http://www.scopus.com/inward/record.url?eid=2-s2.0-46349095615&partnerID=MN8TOARS
George, C., Lai, F., & George, C. (2007). Developing New Anti-Arrhythmics: Clues from the Molecular Basis of Cardiac Ryanodine Receptor (RyR2) Ca2+-Release Channel Dysfunction. Current Pharmaceutical Design, 13(31), 3195-3211.
https://doi.org/10.2174/138161207782341259, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35366
http://www.scopus.com/inward/record.url?eid=2-s2.0-36749102543&partnerID=MN8TOARS
George, C. (2007). Site-directed mutagenesis of Serine 2815 on the cardiac ryanodine receptor and resultant effects on channel function. In Proceedings of The Physiological SocietyThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35723
George, C. (2007). Modulating intracellular Ca2+ signaling using recombinant fragments of the human cardiac ryanodine receptor. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35762
George, C. (2007). Targeting the RyR2 I-domain as a novel strategy to correct mutationlinked Ca2+ release channel dysfunction.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35738
George, C. (2006). A novel cardiomyocyte FRET-based bioassay for investigating the molecular basis of RyR2 dysfunction in arrhythmogenesis. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35763
George, C. (2006). Exercise-induced factors in human serum trigger abnormal Ca2+ release via cardiac ryanodine receptor (RyR2) mutations. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35764
George, C. (2006). Ryanodine receptor mutations and ventricular arrhythmias: channel instability at the heart of Ca 2+ release dysfunction. Journal of Molecular and Cellular Cardiology, 40
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35747
George, C. & Lai, F. (2006). Molecular Biology of Ryanodine Receptors
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35388
George, C., Chang, C., Lai, F., & George, C. (2005). Toward a Molecular Understanding of the Structure–Function of Ryanodine Receptor Ca2+ Release Channels: Perspectives From Recombinant Expression Systems. Cell Biochemistry and Biophysics, 42(2), 197-222.
https://doi.org/10.1385/CBB:42:2:197, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35359
http://www.scopus.com/inward/record.url?eid=2-s2.0-24644495728&partnerID=MN8TOARS
Burr, M., Dunstan, F., George, C., & George, C. (2005). Is Fish Oil Good or Bad for Heart Disease? Two Trials with Apparently Conflicting Results. Journal of Membrane Biology, 206(2), 155-163.
https://doi.org/10.1007/s00232-005-0784-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35360
http://www.scopus.com/inward/record.url?eid=2-s2.0-32044471070&partnerID=MN8TOARS
George, C. (2005). In situ characterisation of the Ca2+ sensitivity of cardiac RyR mutations reveals multiple mechanisms of channel dysfunction in sudden death. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35732
George, C. (2005). Visualisation of intra-RyR2 interactions in HL-1 cardiomyocytes: novel FRET probes reveal a structural basis for Ca2+ channel dysfunction in arrhythmogenesis.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35733
George, C. (2004). Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35731
George, C. (2004). Characterisation of the human recombinant cardiac intracellular calcium release channel (ryanodine receptor).. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35728
George, C. (2004). Altered intra-RyR interaction associated with stress-induced ventricular tachycardia.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35735
George, C., Higgs, G., Lai, F., & George, C. (2003). Ryanodine Receptor Mutations Associated With Stress-Induced Ventricular Tachycardia Mediate Increased Calcium Release in Stimulated Cardiomyocytes. Circulation Research, 93(6), 531-540.
https://doi.org/10.1161/01.RES.0000091335.07574.86, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35354
http://www.scopus.com/inward/record.url?eid=2-s2.0-0141571322&partnerID=MN8TOARS
George, C., Sorathia, R., Bertrand, B., Lai, F., & George, C. (2003). In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. Biochemical Journal, 370(2), 579-589.
https://doi.org/10.1042/BJ20021433, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35355
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037338530&partnerID=MN8TOARS
George, C., Higgs, G., Mackrill, J., Anthony Lai, F., & George, C. (2003). Dysregulated Ryanodine Receptors Mediate Cellular Toxicity. Journal of Biological Chemistry, 278(31), 28856-28864.
https://doi.org/10.1074/jbc.M212440200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35356
http://www.scopus.com/inward/record.url?eid=2-s2.0-0042707870&partnerID=MN8TOARS

All Research

Journal Articles

Williams, C., Hather, C., Conteh, J., Zhang, J., Popa, R., Owen, A., Jonas, C., Choi, H., Daniel, R., Lloyd, D., Porch, A., & George, C. (2023). Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. Biochemical and Biophysical Research Communications, 661, 89-98.
https://doi.org/10.1016/j.bbrc.2023.04.038, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63176
http://dx.doi.org/10.1016/j.bbrc.2023.04.038
Stanford, S., Alexander, S., Cirino, G., George, C., Insel, P., Kendall, D., Ji, Y., Panettieri, R., Patel, H., Sobey, C., Stefanska, B., Stephens, G., Teixeira, M., Vergnolle, N., Ferdinandy, P., & Ahluwalia, A. (2023). Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology. British Journal of Pharmacology, 180(9), 1191-1196.
https://doi.org/10.1111/bph.16049, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63277
http://dx.doi.org/10.1111/bph.16049
Ingrande, J., Patel, H., Kendall, D., Stefanska, B., Alexander, S., Bakhle, M., Cirino, G., Docherty, J., George, C., Insel, P., Ji, Y., King, B., Lilley, E., Panettieri, R., Ramage, A., Sobey, C., Stanford, S., Stephens, G., Teixeira, M...., & Ahluwalia, A. (2023). Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. British Journal of Pharmacology, 180(3), 255-263.
https://doi.org/10.1111/bph.15992, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62193
Curtis, M., Alexander, S., Cirino, G., George, C., Kendall, D., Insel, P., Izzo, A., Ji, Y., Panettieri, R., Patel, H., Sobey, C., Stanford, S., Stanley, P., Stefanska, B., Stephens, G., Teixeira, M., Vergnolle, N., & Ahluwalia, A. (2022). Planning experiments: Updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology, 179(15), 3907-3913.
https://doi.org/10.1111/bph.15868, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60174
Bannister, M., MacLeod, K., & George, C. (2022). Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor. British Journal of Pharmacology, 179(11), 2558-2563.
https://doi.org/10.1111/bph.15718, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58568
Hamilton, S., Terentyeva, R., Bogdanov, V., Kim, T., Perger, F., Yan, J., Ai, X., Carnes, C., Belevych, A., George, C., Davis, J., Gyorke, S., Choi, B., & Terentyev, D. (2022). Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia. Circulation Research, 130(5), 711-724.
https://doi.org/10.1161/circresaha.121.320531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59209
Sobey, C., Drummond, G., & George, C. (2022). How good are our models of cardiovascular disease?. British Journal of Pharmacology, 179(5), 745-747.
https://doi.org/10.1111/bph.15761, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59393
Richardson, E., Homem, R., Troczka, B., George, C., Ebbinghaus‐Kintscher, U., Williamson, M., Nauen, R., & Davies, T. (2022). Diamide insecticide resistance in transgenic Drosophila and Sf9-cells expressing a full-length diamondback moth ryanodine receptor carrying an I4790M mutation. Pest Management Science, 78(3), 869-880.
https://doi.org/10.1002/ps.6730, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58748
Richardson, E., Troczka, B., Gutbrod, O., Ebbinghaus-Kintscher, U., Williamson, M., George, C., Nauen, R., & Davies, T. (2021). Chimeric Investigations into the Diamide Binding Site on the Lepidopteran Ryanodine Receptor. International Journal of Molecular Sciences, 22(23), 13033
https://doi.org/10.3390/ijms222313033, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58894
George, C., Alexander, S., Cirino, G., Insel, P., Izzo, A., Ji, Y., Kendall, D., Panettieri, R., Patel, H., Sobey, C., Stanford, S., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2021). Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). British Journal of Pharmacology, 178(18), 3605-3610.
https://doi.org/10.1111/bph.15589, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58711
Hamilton, S., Terentyeva, R., Kim, T., Martin, B., Bogdanov, V., Belevych, A., George, C., Gyorke, S., Choi, B., Davis, J., & Terentyev, D. (2021). The Sarcoplasmic Reticulum Oxidoreductase System Modulates Luminal Ca2+ Regulation of the Ryanodine Receptor in Cardiac Disease. Biophysical Journal, 120(3), 239a
https://doi.org/10.1016/j.bpj.2020.11.1575, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58712
Fenton, D., Phillips, D., Maddison, A., George, C., Ryves, J., & Jones, H. (2020). Cupid, a cell permeable peptide derived from amoeba, capable of delivering GFP into a diverse range of species. Scientific Reports, 10(1)
https://doi.org/10.1038/s41598-020-70532-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54856
Lilley, E., Stanford, S., Kendall, D., Alexander, S., Cirino, G., Docherty, J., George, C., Insel, P., Izzo, A., Ji, Y., Panettieri, R., Sobey, C., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2020). ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. British Journal of Pharmacology, 177(16), 3611-3616.
https://doi.org/10.1111/bph.15178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54748
Izzo, A., Teixeira, M., Alexander, S., Cirino, G., Docherty, J., George, C., Insel, P., Ji, Y., Kendall, D., Panattieri, R., Sobey, C., Stanford, S., Stefanska, B., Stephens, G., & Ahluwalia, A. (2020). A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. British Journal of Pharmacology, 177(10), 2169-2178.
https://doi.org/10.1111/bph.15054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54011
George, C., Alexander, S., Cirino, G., Docherty, J., Hoyer, D., Insel, P., Izzo, A., Ji, Y., Panettieri, R., Sobey, C., Stanford, S., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2019). The BJP expects authors to share data. British Journal of Pharmacology, 176(24), 4595-4598.
https://doi.org/10.1111/bph.14907, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53360
Docherty, J., Stanford, S., Panattieri, R., Alexander, S., Cirino, G., George, C., Hoyer, D., Izzo, A., Ji, Y., Lilley, E., Sobey, C., Stanley, P., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2019). Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable. British Journal of Pharmacology, 176(21)
https://doi.org/10.1111/bph.14761, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52057
Williams, C. & George, C. (2019). Connect and Conquer: Collectivized Behavior of Mitochondria and Bacteria. Frontiers in Physiology, 10
https://doi.org/10.3389/fphys.2019.00340, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49863
https://www.frontiersin.org/articles/10.3389/fphys.2019.00340/full
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & George, C. (2018). Association of Cardiac Myosin Binding Protein-C with the Ryanodine Receptor-Ca 2+ Release Channel: Putative Retrograde Regulation?. Biophysical Journal, 114(3), 621a
https://doi.org/10.1016/j.bpj.2017.11.3359, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40608
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2018). Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?. Journal of Cell Science, 131(15), jcs210443
https://doi.org/10.1242/jcs.210443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41186
Gintant, G. & George, C. (2018). Introduction to biological complexity as a missing link in drug discovery. Expert Opinion on Drug Discovery, 13(8), 753-763.
https://doi.org/10.1080/17460441.2018.1480608, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40284
Curtis, M., Alexander, S., Cirino, G., Docherty, J., George, C., Giembycz, M., Hoyer, D., Insel, P., Izzo, A., Ji, Y., MacEwan, D., Sobey, C., Stanford, S., Teixeira, M., Wonnacott, S., & Ahluwalia, A. (2018). Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. British Journal of Pharmacology, 175(7), 987-993.
https://doi.org/10.1111/bph.14153, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39095
Williams, A., Thomas, N., & George, C. (2018). The ryanodine receptor: advances in structure and organization. Current Opinion in Physiology, 1, 1-6.
https://doi.org/10.1016/j.cophys.2017.10.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37297
Alexander, S., Roberts, R., Broughton, B., Sobey, C., George, C., Stanford, S., Cirino, G., Docherty, J., Giembycz, M., Hoyer, D., Insel, P., Izzo, A., Ji, Y., MacEwan, D., Mangum, J., Wonnacott, S., & Ahluwalia, A. (2018). Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. British Journal of Pharmacology, 175(3), 407-411.
https://doi.org/10.1111/bph.14112, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38321
George, C., Stanford, S., Alexander, S., Cirino, G., Docherty, J., Giembycz, M., Hoyer, D., Insel, P., Izzo, A., Ji, Y., MacEwan, D., Sobey, C., Wonnacott, S., & Ahluwalia, A. (2017). Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. British Journal of Pharmacology, 174(17), 2801-2804.
https://doi.org/10.1111/bph.13925, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35322
Benson, M., Tinsley, C., Waite, A., Carlisle, F., Sweet, S., Ehler, E., George, C., Lai, F., Martin-Rendon, E., & Blake, D. (2017). Ryanodine receptors are part of the myospryn complex in cardiac muscle. Scientific Reports, 7(1)
https://doi.org/10.1038/s41598-017-06395-6, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35346
Dhanjal, T., Lellouche, N., Ruhland, C., Abehsira, G., Edwards, D., Dubois-Randé, J., Moschonas, K., Teiger, E., Williams, A., & George, C. (2017). Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart. JACC: Clinical Electrophysiology, 3(7), 703-714.
https://doi.org/10.1016/j.jacep.2016.11.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34835
Williams, A., Bannister, M., Thomas, N., Sikkel, M., Mukherjee, S., Maxwell, C., MacLeod, K., George, C., Bannister, M., George, C., Thomas, N., Mukherjee, S., & Williams, A. (2016). Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology, 594(21), 6431-6432.
https://doi.org/10.1113/jp272497, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34319
http://europepmc.org/abstract/med/27800620
George, C., Mitchell, A., Preece, R., Bannister, M., Yousef, Z., Bannister, M., & George, C. (2016). Pleiotropic mechanisms of action of perhexiline in heart failure. Expert Opinion on Therapeutic Patents, 26(9), 1049-1059.
https://doi.org/10.1080/13543776.2016.1211111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34320
Bannister, M., Alvarez-Laviada, A., Thomas, N., Mason, S., Coleman, S., du, P., Moran, A., Neill-Hall, D., Osman, H., Bagley, M., MacLeod, K., George, C., Williams, A., Bannister, M., George, C., Thomas, N., & Williams, A. (2016). Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology, 173(15), 2446-2459.
https://doi.org/10.1111/bph.13521, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34321
http://europepmc.org/abstract/med/27237957
Jones, A., Edwards, D., Cummins, M., Williams, A., & George, C. (2016). A Systemized Approach to Investigate Ca2+ Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes. Frontiers in Cell and Developmental Biology, 3
https://doi.org/10.3389/fcell.2015.00089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35904
Bannister, M., Thomas, N., Sikkel, M., Mukherjee, S., Maxwell, C., MacLeod, K., George, C., Williams, A., Bannister, M., George, C., Thomas, N., Mukherjee, S., & Williams, A. (2015). The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2. Circulation Research, 116(8), 1324-1335.
https://doi.org/10.1161/CIRCRESAHA.116.305347, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34834
Lewis, K., Silvester, N., Barberini-Jammaers, S., Mason, S., Marsh, S., Lipka, M., George, C., & George, C. (2015). A New System for Profiling Drug-Induced Calcium Signal Perturbation in Human Embryonic Stem Cell–Derived Cardiomyocytes. Journal of Biomolecular Screening, 20(3), 330-340.
https://doi.org/10.1177/1087057114557232, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35378
http://www.scopus.com/inward/record.url?eid=2-s2.0-84923327914&partnerID=MN8TOARS
Boileau, E., George, C., Parthimos, D., Mitchell, A., Aziz, S., & Nithiarasu, P. (2015). Synergy Between Intercellular Communication and Intracellular Ca2+ Handling in Arrhythmogenesis. Annals of Biomedical Engineering, 43(7), 1614-1625.
https://doi.org/10.1007/s10439-014-1243-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa21238
http://link.springer.com/article/10.1007/s10439-014-1243-x
George, C. (2012). What really causes arrhythmias in heart failure?. British Society for Heart Failure, Supplement, 18
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35389
George, C., Parthimos, D., Silvester, N., & George, C. (2012). A network-oriented perspective on cardiac calcium signaling. AJP: Cell Physiology, 303(9), C897-C910.
https://doi.org/10.1152/ajpcell.00388.2011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35376
http://www.scopus.com/inward/record.url?eid=2-s2.0-84868322954&partnerID=MN8TOARS
Silvester, N., George, C., & George, C. (2011). Searching for new cardiovascular drugs: towards improved systems for drug screening?. Expert Opinion on Drug Discovery, 6(11), 1155-1170.
https://doi.org/10.1517/17460441.2011.625652, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35373
http://www.scopus.com/inward/record.url?eid=2-s2.0-80755130608&partnerID=MN8TOARS
Phillips, S., Yu, Y., Rossbach, A., Nomikos, M., Vassilakopoulou, V., Livaniou, E., Cumbes, B., Lai, F., George, C., Swann, K., Cumbes, B., & George, C. (2011). Divergent effect of mammalian PLCζ in generating Ca2+oscillations in somatic cells compared with eggs. Biochemical Journal, 438(3), 545-553.
https://doi.org/10.1042/BJ20101581, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35374
http://www.scopus.com/inward/record.url?eid=2-s2.0-80052162953&partnerID=MN8TOARS
Eisner, D., George, C., Smith, G., Trafford, A., Venetucci, L., & George, C. (2010). How does CaMKII phosphorylation of the cardiac ryanodine receptor contribute to inotropy?. Proceedings of the National Academy of Sciences, 107(31), E123-E123.
https://doi.org/10.1073/pnas.1008809107, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35372
http://www.scopus.com/inward/record.url?eid=2-s2.0-77956375917&partnerID=MN8TOARS
Raby, A., Le Bouder, E., Colmont, C., Davies, J., Richards, P., Coles, B., George, C., Jones, S., Brennan, P., Topley, N., Labéta, M., & George, C. (2009). Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering. The Journal of Immunology, 183(1), 506-517.
https://doi.org/10.4049/jimmunol.0802909, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35371
http://www.scopus.com/inward/record.url?eid=2-s2.0-68949110135&partnerID=MN8TOARS
George, C. (2008). Evidence for serca and BK Ca activation in BNP protection of reperfused myocardium. Journal of Molecular and Cellular Cardiology, 44
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35753
George, C. & George, C. (2008). Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?. Cardiovascular Research, 77(2), 302-314.
https://doi.org/10.1093/cvr/cvm006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35368
http://www.scopus.com/inward/record.url?eid=2-s2.0-38849149701&partnerID=MN8TOARS
George, C., Barberini-Jammaers, S., Muller, C., & George, C. (2008). Refocussing therapeutic strategies for cardiac arrhythmias: defining viable molecular targets to restore cardiac ion flux. Expert Opinion on Therapeutic Patents, 18(1), 1-19.
https://doi.org/10.1517/13543776.18.1.1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35369
http://www.scopus.com/inward/record.url?eid=2-s2.0-39749193540&partnerID=MN8TOARS
George, C. & George, C. (2008). Genetic polymorphisms in β1 and β2 adrenergic receptors: Variations without a theme?. Heart Rhythm, 5(6), 822-825.
https://doi.org/10.1016/j.hrthm.2008.03.034, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35370
http://www.scopus.com/inward/record.url?eid=2-s2.0-46349095615&partnerID=MN8TOARS
George, C., Jundi, H., Thomas, N., Fry, D., Lai, F., George, C., & Thomas, N. (2007). Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies. Journal of Molecular and Cellular Cardiology, 42(1), 34-50.
https://doi.org/10.1016/j.yjmcc.2006.08.115, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35329
http://www.scopus.com/inward/record.url?eid=2-s2.0-33845611191&partnerID=MN8TOARS
Thomas, N., George, C., Williams, A., Lai, F., George, C., Thomas, N., & Williams, A. (2007). Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochemical Society Transactions, 35(5), 946-951.
https://doi.org/10.1042/BST0350946, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35330
http://www.scopus.com/inward/record.url?eid=2-s2.0-36749067461&partnerID=MN8TOARS
George, C., Rogers, S., Bertrand, B., Tunwell, R., Thomas, N., Steele, D., Cox, E., Pepper, C., Hazeel, C., Claycomb, W., Lai, F., George, C., & Thomas, N. (2007). Alternative Splicing of Ryanodine Receptors Modulates Cardiomyocyte Ca2+ Signaling and Susceptibility to Apoptosis. Circulation Research, 100(6), 874-883.
https://doi.org/10.1161/01.RES.0000260804.77807.cf, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35331
http://www.scopus.com/inward/record.url?eid=2-s2.0-34147174284&partnerID=MN8TOARS
George, C., Lai, F., & George, C. (2007). Developing New Anti-Arrhythmics: Clues from the Molecular Basis of Cardiac Ryanodine Receptor (RyR2) Ca2+-Release Channel Dysfunction. Current Pharmaceutical Design, 13(31), 3195-3211.
https://doi.org/10.2174/138161207782341259, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35366
http://www.scopus.com/inward/record.url?eid=2-s2.0-36749102543&partnerID=MN8TOARS
Thomas, N., George, C., Lai, F., George, C., & Thomas, N. (2006). Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?. Biochemical Society Transactions, 34(5), 913-918.
https://doi.org/10.1042/BST0340913, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35327
http://www.scopus.com/inward/record.url?eid=2-s2.0-33751292623&partnerID=MN8TOARS
George, C., Jundi, H., Walters, N., Thomas, N., West, R., Lai, F., George, C., & Thomas, N. (2006). Arrhythmogenic Mutation-Linked Defects in Ryanodine Receptor Autoregulation Reveal a Novel Mechanism of Ca2+ Release Channel Dysfunction. Circulation Research, 98(1), 88-97.
https://doi.org/10.1161/01.RES.0000199296.70534.7c, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35328
http://www.scopus.com/inward/record.url?eid=2-s2.0-33644837101&partnerID=MN8TOARS
George, C. (2006). Ryanodine receptor mutations and ventricular arrhythmias: channel instability at the heart of Ca 2+ release dysfunction. Journal of Molecular and Cellular Cardiology, 40
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35747
Thomas, N., Lai, F., George, C., George, C., & Thomas, N. (2005). Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochemical and Biophysical Research Communications, 331(1), 231-238.
https://doi.org/10.1016/j.bbrc.2005.02.194, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35325
http://www.scopus.com/inward/record.url?eid=2-s2.0-17444376389&partnerID=MN8TOARS
George, C., Chang, C., Lai, F., & George, C. (2005). Toward a Molecular Understanding of the Structure–Function of Ryanodine Receptor Ca2+ Release Channels: Perspectives From Recombinant Expression Systems. Cell Biochemistry and Biophysics, 42(2), 197-222.
https://doi.org/10.1385/CBB:42:2:197, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35359
http://www.scopus.com/inward/record.url?eid=2-s2.0-24644495728&partnerID=MN8TOARS
Burr, M., Dunstan, F., George, C., & George, C. (2005). Is Fish Oil Good or Bad for Heart Disease? Two Trials with Apparently Conflicting Results. Journal of Membrane Biology, 206(2), 155-163.
https://doi.org/10.1007/s00232-005-0784-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35360
http://www.scopus.com/inward/record.url?eid=2-s2.0-32044471070&partnerID=MN8TOARS
George, C., Thomas, N., Lai, F., George, C., & Thomas, N. (2005). Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiology, 1(4), 531-541.
https://doi.org/10.2217/14796678.1.4.531, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35326
http://europepmc.org/abstract/med/19804154
George, C., Jundi, H., Thomas, N., Scoote, M., Walters, N., Williams, A., Lai, F., George, C., Thomas, N., & Williams, A. (2004). Ryanodine Receptor Regulation by Intramolecular Interaction between Cytoplasmic and Transmembrane Domains. Molecular Biology of the Cell, 15(6), 2627-2638.
https://doi.org/10.1091/mbc.E03-09-0688, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35323
http://www.scopus.com/inward/record.url?eid=2-s2.0-2542448132&partnerID=MN8TOARS
Thomas, N., George, C., Lai, F., George, C., & Thomas, N. (2004). Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovascular Research, 64(1), 52-60.
https://doi.org/10.1016/j.cardiores.2004.06.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35324
http://europepmc.org/abstract/med/15364613
George, C., Higgs, G., Lai, F., & George, C. (2003). Ryanodine Receptor Mutations Associated With Stress-Induced Ventricular Tachycardia Mediate Increased Calcium Release in Stimulated Cardiomyocytes. Circulation Research, 93(6), 531-540.
https://doi.org/10.1161/01.RES.0000091335.07574.86, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35354
http://www.scopus.com/inward/record.url?eid=2-s2.0-0141571322&partnerID=MN8TOARS
George, C., Sorathia, R., Bertrand, B., Lai, F., & George, C. (2003). In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. Biochemical Journal, 370(2), 579-589.
https://doi.org/10.1042/BJ20021433, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35355
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037338530&partnerID=MN8TOARS
George, C., Higgs, G., Mackrill, J., Anthony Lai, F., & George, C. (2003). Dysregulated Ryanodine Receptors Mediate Cellular Toxicity. Journal of Biological Chemistry, 278(31), 28856-28864.
https://doi.org/10.1074/jbc.M212440200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35356
http://www.scopus.com/inward/record.url?eid=2-s2.0-0042707870&partnerID=MN8TOARS
George, C. (2001). CELL DEATH INDUCED BY OVEREXPRESSION OF THE HUMAN CARDIAC RYANODINE RECEPTOR (hRYR2) CAN BE PREVENTED BY CO-EXPRESSION WITH FK506-BINDING PROTEIN 12.6 (FKBP12. 6). Heart, 85
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35719
George, C. (2000). Targeted bioluminescent indicators in living cells. Methods in Enzymology, 375, 479-498.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35387
Martin, P., Mambetisaeva, E., Archer, D., George, C., Evans, W., & George, C. (2000). Analysis of Gap Junction Assembly Using Mutated Connexins Detected in Charcot-Marie-Tooth X-Linked Disease. Journal of Neurochemistry, 74(2), 711-720.
https://doi.org/10.1046/j.1471-4159.2000.740711.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35353
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033963213&partnerID=MN8TOARS
Ahmad, S., Diez, J., George, C., Evans, W., & George, C. (1999). Synthesis and assembly of connexins in vitro into homomeric and heteromeric functional gap junction hemichannels. Biochemical Journal, 339(2), 247
https://doi.org/10.1042/0264-6021:3390247, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35351
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033560718&partnerID=MN8TOARS
George, C., Kendall, J., Evans, W., & George, C. (1999). Intracellular Trafficking Pathways in the Assembly of Connexins into Gap Junctions. Journal of Biological Chemistry, 274(13), 8678-8685.
https://doi.org/10.1074/jbc.274.13.8678, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35352
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033605658&partnerID=MN8TOARS
George, C., Martin, P., Evans, W., & George, C. (1998). Rapid Determination of Gap Junction Formation Using HeLa Cells Microinjected with cDNAs Encoding Wild-Type and Chimeric Connexins. Biochemical and Biophysical Research Communications, 247(3), 785-789.
https://doi.org/10.1006/bbrc.1998.8835, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35347
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577887&partnerID=MN8TOARS
George, C., Kendall, J., Campbell, A., Evans, W., & George, C. (1998). Connexin-Aequorin Chimerae Report Cytoplasmic Calcium Environments along Trafficking Pathways Leading to Gap Junction Biogenesis in Living COS-7 Cells. Journal of Biological Chemistry, 273(45), 29822-29829.
https://doi.org/10.1074/jbc.273.45.29822, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35348
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032491419&partnerID=MN8TOARS
Martin, P., George, C., Castro, C., Kendall, J., Capel, J., Campbell, A., Revilla, A., Barrio, L., Evans, W., & George, C. (1998). Assembly of Chimeric Connexin-Aequorin Proteins into Functional Gap Junction Channels. Journal of Biological Chemistry, 273(3), 1719-1726.
https://doi.org/10.1074/jbc.273.3.1719, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35349
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031953118&partnerID=MN8TOARS
George, C. (1998). Reporting the Calcium Environment in Trafficking Pathways Leading to Gap Junction Biogenesis Using Connexin-Aequorin Chimerae. Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35745
Panettieri, R., Stanford, S., Alexander, S., Cirino, G., George, C., Insel, P., Kendall, D., Ji, Y., Patel, H., Sobey, C., Stefanska, B., Stephens, G., Teixeira, M., Vergnolle, N., Ferdinandy, P., & Ahluwalia, A. (n.d.) BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. British Journal of Pharmacology, 180(12)
https://doi.org/10.1111/bph.16089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63278
http://dx.doi.org/10.1111/bph.16089

Book Chapters

Viero, C., Thomas, N., Euden, J., Mason, S., George, C., & Williams, A. (2012). Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level. Calcium Signaling (pp. 183-215).
https://doi.org/10.1007/978-94-007-2888-2_8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35375
http://www.scopus.com/inward/record.url?eid=2-s2.0-84859891796&partnerID=MN8TOARS
Evans, W., Ahmad, S., Diez, J., George, C., Kendall, J., Martin, P., & George, C. (1999). Trafficking pathways leading to the formation of gap junctions. Novartis Foundation Symposium
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35350
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032617032&partnerID=MN8TOARS
Martin, P., Castro, C., George, C., Capel, J., Campbell, A., Revilla, A., Barrio, L., & Evans, H. (1998). Targeting connexin-aequorin chimera to the gap junction. Gap junctions (pp. 107-111).
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35385
George, C., Kendall, J., Campbell, A., Martin, P., & Evans, H. (1998). Reporting the calcium environment in trafficking pathways leading to gap junction biogenesis using connexion-aequorin chimera.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35386
George, C. & Edwards, D. (n.d.) Decoding Ca2+ Signals as a Non-electrophysiological Method for Assessing Drug Toxicity in Stem Cell-Derived Cardiomyocytes. Stem Cell-Derived Models in Toxicology (pp. 173-190). Humana Press
https://doi.org/10.1007/978-1-4939-6661-5_9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35382

Conference Contributions

George, C. (2016). Effect of flecainide derivatives on sarcoplasmic reticulum Ca2+ release confirms a lack of direct action on the cardiac ryanodine receptor. In Biophysical JournalThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35720
George, C. (2016). Increased myofibroblast densities are specific to critical isthmus sites in post-infarct re-entrant ventricular tachycardia. In Heart Rhythm SocietyHeart Rhythm Society, San Francisco, May 2016..
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35756
George, C. (2016). LAVA sites are histologically closely related to critical isthmus sites in post-infarct ventricular tachycardia. In Heart Rhythm Society
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35757
George, C. (2015). Cellular characterisation of stromal cell and cardiomyocyte coupling at the critical isthmus in an in vivo swine model of post-infarction re-entrant ventricular tachycardia. In Journal of Investigative Cardiac Electrophysiology
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35758
George, C. (2015). The mechanism of flecainide action in catecholaminergic polymorphic ventricular tachycardia does not involve a direct effect on the ryanodine receptor. In Proceedings of The Physiological SocietyThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35721
George, C. (2015). Fundamental gating defects of sudden cardiac death-linked mutant cardiac ryanodine receptors determine Ca2+ release dynamics in cells. In Proceedings of The Physiological SocietyThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35722
George, C. (2014). Predictive Drug Toxicity Profiling using a New Mode of Calcium Signal Analysis in Human Es-Derived Cardiomyocytes. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35724
George, C. (2014). The Metabolic Modulator Perhexiline Induces Calcium-Cycling Dysfunction and Apoptosis in Cardiomyocyte Syncytia. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35725
George, C. (2013). Manipulating RyR2 Ca2+ Signalling in Cardiomyocyte Networks using Morpholino Oligonucleotides. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35739
George, C. (2013). An Assessment of Calcium Handling and Cardiovascular Drug-Profiling in Cytiva Embryonic Stem-Cell Derived Cardiomyocytes. In Biophys JElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35740
George, C. (2013). Exploring the Link between Ca2+ Signalling and ATP Dynamics in Cardiomyocyte Dysfunction. In Biophysical JournalElsevier.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35741
George, C. (2011). Ouabain is a Pharmacomimic of Mutant RyR2 Ca2+ Release Dysfunction but is not a Serum-Borne Trigger of CPVT. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35727
George, C. (2011). Trans Complementation with the Common G1885E Polymorphism Attenuates Mutant RyR2 L433P Channel Dysfunction. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35748
George, C. (2011). Targeted Inhibition of Connexin 43 Hemichannels Blunts Ca 2+-Induced Intercellular Dyssynchrony and ATP Efflux in Hl-1 Cardiomyocyte Syncitia. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35749
George, C. (2010). Biophysical and Cellular Characterisation of Alternatively Spliced Isoforms of the Human Cardiac Ryanodine Receptor (RyR2). In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35744
George, C. (2010). Adaptive Retuning of Small Ca2+ Fluxes in Cardiomyocyte Syncytia Predicts the Response To Pro-Arrhythmic Stimuli. In Biophys J
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35746
George, C. (2009). Investigating the Ca 2+-cycling basis of rhythmicity and synchronicity in coupled cardiomyocyte monolayers. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35742
George, C. (2009). Decoding The Molecular Basis Of Anti-Apoptotic Cardiac Ca 2+ Signalling Via Human RyR2 Splice Variants. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35743
George, C. (2009). An L433P Arrhythmia-linked Mutation In RyR2 Uncouples Agonist-evoked Ca 2+ Release From Homeostatic Ca 2+ Cycling. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35750
George, C. (2009). Targeted Stabilisation Of The RyR2 I-Domain Restores Ca 2+ Handling And Intercellular Synchrony In Ouabain-disrupted Cardiac Cell Monolayers. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35751
George, C. (2009). A G1885E RyR2 polymorphism modulates the caffeine sensitivity of an arrhythmia-linked mutation. In Biophysical JournalCell Press.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35754
George, C. (2008). Mutation-linked instability underlies RyR2 channel hypersensitivity to serum-borne factors. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35759
George, C. (2008). SALVO- a new analytical platform for decoding intracellular Ca2+ fluxes and evaluating anti-arrhythmic compounds. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35760
George, C. (2008). Suppression of arrhythmogenic Ca2+ fluxes in cardiac cells using fragments of human RyR2. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35761
George, C. (2007). Site-directed mutagenesis of Serine 2815 on the cardiac ryanodine receptor and resultant effects on channel function. In Proceedings of The Physiological SocietyThe Physiological Society.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35723
George, C. (2007). Modulating intracellular Ca2+ signaling using recombinant fragments of the human cardiac ryanodine receptor. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35762
George, C. (2007). Targeting the RyR2 I-domain as a novel strategy to correct mutationlinked Ca2+ release channel dysfunction.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35738
George, C. (2006). A novel cardiomyocyte FRET-based bioassay for investigating the molecular basis of RyR2 dysfunction in arrhythmogenesis. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35763
George, C. (2006). Exercise-induced factors in human serum trigger abnormal Ca2+ release via cardiac ryanodine receptor (RyR2) mutations. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35764
George, C. (2005). In situ characterisation of the Ca2+ sensitivity of cardiac RyR mutations reveals multiple mechanisms of channel dysfunction in sudden death. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35732
George, C. (2005). Visualisation of intra-RyR2 interactions in HL-1 cardiomyocytes: novel FRET probes reveal a structural basis for Ca2+ channel dysfunction in arrhythmogenesis.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35733
George, C. (2004). Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35731
George, C. (2004). Characterisation of the human recombinant cardiac intracellular calcium release channel (ryanodine receptor).. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35728
George, C. (2004). Altered intra-RyR interaction associated with stress-induced ventricular tachycardia.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35735
George, C. (2003). Expression of human RyR2 splice variants. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35729
George, C. (2003). Transcriptional alterations mediated via dysregulated human cardiac ryanodine receptor (hRyR2).. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35726
George, C. (2002). Cytoplasmic Ca2+ spiking via human RyR2 mediates cell death. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35736
George, C. (2002). In situ regulation of the human cardiac ryanodine receptor (hRyR2) by intramolecular interaction. In Biophysical Journal
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35737
George, C. (2001). In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12. 6.. In BIOPHYSICAL JOURNAL
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35730

Other Research Outputs

George, C. (2010). Method and system for analyzing calcium transients in coupled cells
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35752
George, C. (2008). Modulating intracellular Ca2+ signalling using recombinant fragments of the human cardiac ryanodine receptor (RyR2)
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35734
George, C. & Lai, F. (2006). Molecular Biology of Ryanodine Receptors
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35388

Supervision

Novel Ultrasound Technology and Community Pathway Interventions to Improve Healthcare Outcomes in Remote and Low Resource Settings (current)

PhD

Other supervisor: Dr Emma Rees
New Methods to Map the Transition from 'Normal-to-Abnormal' in Networks of Stem Cell-Derived Cardiomyocytes (current)

PhD

Other supervisor: Dr Sanjay Pant
Modelling Variability in Homeostatic System Behaviour in hiPSC-Derived Cardiac Networks: The Nexus of Mathematical and Biological Approaches (current)

MSc

Other supervisor: Dr Noemi Picco
The contribution of inter-spike calcium noise to oscillatory deterioration in arrhythmia-susceptible human cardiomyocytes (current)

MSc

Other supervisor: Prof Paul Rees

Taught Modules

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-266 The Cardiovascular System

Leading on from the first year Human Physiology Module (PM-154), the Cardiovascular Module will introduce and define the fundamental cellular mechanisms that regulate the physiology of healthy cardiovascular function. The Module will describe the processes that allow regular heartbeat and blood vessel function and how perturbations in the systems covered may lead to pathophysiological conditions. There will be an emphasis on experimental approaches used to study the cardiovascular mechanisms described.
PM-267 Pharmacogenomics: Genes on Drugs

Pharmacogenomics is the study of how a person¿s genomic information can affect their response to drugs and therapeutics, predicting if a patient will respond badly, too much or too little to a chosen therapy. This is the underlying principle of `personalised medicine¿, ensuring the right patient, gets the right drug, at the right time. Within this module, students will look at the principles of pharmacogenomics, namely the variation in genomics sequences from patients to patients which can alter the pharmacokinetics and pharmacodynamics of therapeutics. In this module, students will learn about the role of pharmacogenomics in chemotherapy, gastrointestinal drugs, cardiovascular drugs, respiratory drugs, neurological drugs and drugs used in the treatment of infectious disease.
PM-340 Being a Medical Scientist

Much of a scientist¿s career is spent writing and speaking about science. The aim of this module is to give students a higher level experience of what being a lead researcher is like, away from the lab bench. Drawing on core knowledge from other modules, students will refine their oral and written communication and learn what leadership skills are needed to succeed in modern science. They will also be challenged to consider ethical aspects of research, including new technologies and the use of animal and human subjects. The module will be highly interactive, taught using informal lectures interspersed with students working in groups.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-358 Tissue Engineering and Regenerative Medicine

This module will provide students with a firm understanding of the principles of Regenerative Medicine that extend from cellular to tissue and organ repair and regeneration. This module will focus on the practical aspects of revolutionary technologies, generated through research, that have the potential to significantly improve how we treat injury, illness and disease.
PMGM17 Dissertation Project

The module is for students to build on their previous knowledge, skills and experience by undertaking a laboratory based or suitable non-laboratory based project on a specific subject related to genomics.

Professor Christopher George

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Welsh language proficiency

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Journal Articles

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Other Research Outputs

Supervision

Novel Ultrasound Technology and Community Pathway Interventions to Improve Healthcare Outcomes in Remote and Low Resource Settings (current)

New Methods to Map the Transition from 'Normal-to-Abnormal' in Networks of Stem Cell-Derived Cardiomyocytes (current)

Modelling Variability in Homeostatic System Behaviour in hiPSC-Derived Cardiac Networks: The Nexus of Mathematical and Biological Approaches (current)

The contribution of inter-spike calcium noise to oscillatory deterioration in arrhythmia-susceptible human cardiomyocytes (current)

Taught Modules

PM-130 Fundamental Research Skills

PM-266 The Cardiovascular System

PM-267 Pharmacogenomics: Genes on Drugs

PM-340 Being a Medical Scientist

PM-344 Capstone Project

PM-358 Tissue Engineering and Regenerative Medicine

PMGM17 Dissertation Project