(Chemistry) Fully-funded College of Science-Faculty of Science and Engineering PhD Scholarship 2021/22

The Chemical Biology of Mismatch DNA

Project Supervisors:

Closing date: Wednesday 31th March 2021

Start date: 1 October 2021

Project description:

DNA containing non-Watson crick “mismatch” base pairs (mismatch DNA or mismatches) has experienced a resurgence of interest. While normal cells repair mismatches by mismatch mediated repair (MMR), cells deficient in MMR have a high level of unrepaired replication errors, including mismatches. New molecules with high affinities for mismatch DNA would be advantageous for the biophysical and biochemical study of these DNA lesions and provide molecular tools or therapeutic leads for MMR-deficient cancers. In this project, you will synthesise compounds based on metal polypyridyl chemistry (ruthenium, iridium, platinum metal centres) to examine the biochemistry and cell biology of mismatch DNA and establish whether mismatches are a viable target in medicinal chemistry. This project is highly interdisciplinary and will involve methodologies and techniques from synthetic organometallic and coordination chemistry, DNA biochemistry, and cancer cell biology; a unique combination of skills with opportunities to specialise in these areas. Recent publications from the group include Gill et al., Chem Sci 2020, 11 (33), 8936-8944, Yusoh et al., ACS Chem Biol 2020 15, 378-387 and Yusoh et al. ChemMedChem 2020 15 (22), 2121-2135. For more information please visit our website: gillchembiol.com

Requirements:

Candidates must have a First, Upper Second Class Honours or a Master’s degree with Merit, in a relevant discipline (Chemistry, Biochemistry, Cell/Molecular Biology or related). Informal enquiries before the deadline for formal applications are welcome by emailing m.r.gill@swansea.ac.uk

For candidates whose first language is not English, we require IELTS 6.5 (with 6.0 in each component) or equivalent. Please visit our website for a list of acceptable English language tests. We prefer candidates to have already met the English Language requirements at the point of application, although this is not a requirement.

Funding:

This is a three-year fully-funded College of Science scholarship, which covers UK tuition fees at home rate and an annual stipend of £15,285 (2021-22). The studentship also includes a Research Training Support Grant allocation of £1,000 per annum for three years.

Eligibility:

The call is open to students who are eligible to apply for postgraduate research tuition fees at home rate. For EU students, please notice the PGR Transitional Bursary Scheme for EU Students 2021/22 Entry:

https://www.swansea.ac.uk/international-students/my-finances/international-scholarships/pgr-eu-bursary/

How to apply:

Candidates must complete and submit the following documentation by the stated deadline. To apply for this studentship, please download and complete the research scholarship application form and return them to the College of Science with the following:

  • Academic References – all scholarship applications require two supporting references to be submitted. Please ensure that your chosen referees are aware of the funding deadline, as their references form a vital part of the evaluation process. Please either include these with your scholarship application or ask your referees to send them directly to science-scholarships@swansea.ac.uk
  • Academic Transcripts and Degree Certificates – academic transcripts and degree certificates must be submitted along with the scholarship application by the funding deadline. We will be using these to verify your academic qualifications.
  • A recent CV

Candidates should use the ‘Supplementary Personal Statement’ section of the application form to explain why the award they are applying for particularly matches their skills and experience and how they would choose to develop the project.

Please email the documents to science-scholarships@swansea.ac.uk and put ‘ECR 01/02 SCHOLARSHIPs 2021-2022’ in the email subject header.