Publications

Journal Articles

  1. & Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research 105(1), 118-128.
  2. & Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart. JACC: Clinical Electrophysiology 3(7), 703-714.
  3. & Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology 594(21), 6431-6432.
  4. & Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science, jcs.191643
  5. & Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating. Scientific Reports 6(1)
  6. & Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology 173(15), 2446-2459.
  7. & A Systemized Approach to Investigate Ca2+ Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes. Frontiers in Cell and Developmental Biology 3
  8. & Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1. Cell Research 26(9), 977-994.
  9. & The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2. Circulation Research 116(8), 1324-1335.
  10. & Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides. Scientific Reports 5, 14680
  11. & Molecular cloning, characterisation and mRNA expression of the ryanodine receptor from the peach-potato aphid, Myzus persicae. Gene 556(2), 106-112.
  12. & Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research 105(1), 118-128.
  13. & Insights into the Gating Mechanism of the Ryanodine-Modified Human Cardiac Ca2+-Release Channel (Ryanodine Receptor 2). Molecular Pharmacology 86(3), 318-329.
  14. & N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science 126(21), 5042-5051.
  15. & Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating. Journal of Biological Chemistry 288(23), 16671-16679.
  16. & Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply. Cardiovascular Research 98(2), 327-328.
  17. & Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current. Cardiovascular Research 98(2), 286-296.
  18. & Functional Characterization of the Cardiac Ryanodine Receptor Pore-Forming Region. PLoS ONE 8(6), e66542
  19. & The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations andShakerB inactivation peptides. The Journal of General Physiology 140(3), 325-339.
  20. & A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment. The Journal of General Physiology 140(2), 139-158.
  21. & Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science 125(7), 1759-1769.
  22. & Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Advances in experimental Medicine and Biology 740, 183-215.
  23. & Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction. FEBS Letters 584(10), 2153-2160.
  24. & Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. Biochemical and Biophysical Research Communications 387(1), 77-82.
  25. & The interaction of ryanoids with individual ryanodine receptor channels. Biological Research 37(4), 527-538.
  26. Ion conduction and selectivity in the ryanodine receptor channel. Frontiers in Bioscience 7(4), d1223-1230.
  27. & Cyclic ADP-ribose and related compounds activate sheep skeletal sarcoplasmic reticulum Ca2+ release channel. American Journal of Physiology 268(5 Pt 1), C1235-C1240.
  28. & Modification of the gating of the cardiac sarcoplasmic reticulum calcium-release channel by H2O2 and dithiothreitol. American Journal of Physiology Heart Circulation Physiology 267, H1010-H1016.
  29. The calcium-release channel from cardiac sarcoplasmic reticulum: function in the failing and acutely ischaemic heart. Basic Research in Cardiology 87(1), 255-268.
  30. Ion conduction and discrimination in the sarcoplasmic reticulum ryanodine receptor/calcium-release channel. Journal of Muscle Research and Cell Motility 13(1), 7-26.
  31. & Reactive oxygen species modify the structure and function of the cardiac sarcoplasmic reticulum calcium-release channel. Cardioscience 2(1), 19-25.
  32. & Cardiovascular receptors and calcium. Circulation Research 46(6 Pt 2), 161-166.
  33. & Sarcolemmal calcium transport and drug action. Advances in Myocardiology 1, 77-94.
  34. & Relaxation in heart muscle: some morphological and biochemical considerations. European Journal of Cardiology 7, 35-50.

Book Chapters

  1. & The pore of the ryanodine receptor channel. In The Ryanodine Receptor Pore. (pp. 43-52). New York: Springer.