Dr Yuqin Wang
Associate Professor
Swansea University Medical School
Telephone: (01792) 602730

Publications

  1. et. al. An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLOS Biology 14(3), e1002364
  2. & The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology
  3. & The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis. Journal of Allergy and Clinical Immunology
  4. & Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. The Journal of Steroid Biochemistry and Molecular Biology
  5. & Current trends in oxysterol research. Biochemical Society Transactions 44(2), 652-658.

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Teaching

  • PMLM02 LC/MS Applications I: Proteomics

    Proteomics sample preparation and separation: protein extraction from cell and tissue, 1D and 2D gel electrophresis, protein digestion (in gel and in solution), peptide separation by SCX and RP-HPLC Mass Spectrometry analysis: peptide fragmentation via CID, LC-MS/MS, interpretation of CID spectrum of peptide Protein identification by database search: principle of database search, software for database search, interpretation of the results Quantitative proteomics: 2D gel ¿based protein quantification, MS-based protein quantification Characterization PTM by mass spectrometry Sample preparation and analysis of phosphoproteome: enrichment of phosphoproteins or phosphopeptides, interpretation CID spectrum of phosphopeptide and identification of phosphorylation sites

  • PMLM05 LC/MS Applications IV: Medical and life sciences

    Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.

  • PMLM09 Dissertation: MS experimental project.

    Students will have the opportunity to join an established research group to work in a modern and well equipped laboratory or alternatively undertake a suitable non-laboratory based project. In this module the student will be able to gain extensive `hands on¿ specialist expertise in a chosen topic which could be targeted to their future career in the field of mass spectrometry.

Supervision

  • Sensing bacterial infection: 25-hydroxycholesterol as a biomarker (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Thomas Humphrey
    Other supervisor: Dr Yuqin Wang
    Other supervisor: Prof William Griffiths
  • Metabolomics/Lipidomics in Asthmatics with reference to the microbiome of the airway. (current)

    Student name:
    MD
    Other supervisor: Dr Gwyneth Davies
    Other supervisor: Dr Yuqin Wang
    Other supervisor: Prof Julian Hopkin
  • Development and Validation of Assays for Vitamins D and other Sterols using LC-MS and GC-TOF-MS with select -eV (current)

    Student name:
    PhD
    Other supervisor: Prof William Griffiths
    Other supervisor: Dr Yuqin Wang
  • Inhibiting IL-17 Production by Blocking Endogenous RORγt Agonists for the Treatment of Autoimmune Diseases (current)

    Student name:
    PhD
    Other supervisor: Dr Yuqin Wang
    Other supervisor: Prof William Griffiths
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Catherine Thornton
  • 'Development of mass spectrometry based reference methods for the measurement of 25-hydroxyvitamins D2 and D3 and the discovery of related molecules in human serum' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Prof William Griffiths
    Other supervisor: Dr Yuqin Wang
  • 'Lipidomic analysis of sterols in Human T Helper cells' (awarded 2017)

    Student name:
    PhD
    Other supervisor: Dr Yuqin Wang
    Other supervisor: Prof William Griffiths