Professor Catherine Thornton

Publications

  1. & Metabolic adaptation of human CD4+ and CD8+ T cells to TCR mediated stimulation. Frontiers in Immunology
  2. Ovine leukocyte microparticles generated by the CentriMag ventricular assist device in vitro. Artificial Organs
  3. & The effect of ventricular assist device-associated biomaterials on human blood leukocytes. Journal of Biomedical Materials Research Part B: Applied Biomaterials
  4. & Expression and function of NOD-like receptors by human term gestation-associated tissues. Placenta 58, 25-32.
  5. & Production and regulation of interleukin-1 family cytokines at the materno-fetal interface. Cytokine 99, 194-202.

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Teaching

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-304 Biomolecular Research Project

    *

  • PM-341 Human Biology and the Environment

    This module is intended to provide an understanding of how our environmental factors impact on key aspects of human biology. Various environmental factors such as diet, stress, and pollution will be considered with a focus on their effects on epigenetics, inflammation, gut microbiota, mitochondrial health, and oxidative stress in non-communicable diseases in particular (e.g. chronic respiratory disease, cancer and metabolic disorders). The effect of extreme environments (e.g. altitude, space) and ageing on multiple organ systems will be considered. Students will gain practical experience in communicating these issues to scientific and non-scientific audiences.

  • PMLM05 LC/MS Applications IV: Medical and life sciences

    Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.

Supervision

  • 'Natural and Synthetic GHSR1a Agonists as Neurprotective Agents in Models of Parkinson''''s Disease' (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
  • 'Impact of ventricular assist devices on the activity of white blood cells and the implications for device design and testing.' (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Karl Hawkins
  • Raman spectroscopy and colorectal cancer: towards early diagnosis and personalised medicine (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof Peter Dunstan
  • Perceptions of asthma and exercise in children and adolescents (current)

    Student name:
    PhD
    Other supervisor: Dr Gwyneth Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Melitta Mcnarry
  • Ghrelin regulation of the adult hippocampal stem cell niche (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
  • 'Determining the bioenergetic capacity of insect (Galleria mellonella) haemocytes' (current)

    Student name:
    MRes
    Other supervisor: Dr Christopher Coates
    Other supervisor: Prof Catherine Thornton
  • Ghrelin AMPK mediated mitochondrial dynamics (current)

    Student name:
    MSc
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • Untitled (current)

    Student name:
    MSc
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr James Cronin
  • 'Assessing the effects of a viral mimic Poly (I:C) on insect (Galleria mellonella) innate immunity' (current)

    Student name:
    MRes
    Other supervisor: Dr Christopher Coates
    Other supervisor: Prof Catherine Thornton
  • Characterising ghrelin peptide expression in the adult brain: towards a MALDI-imaging method for Parkinson’s disease biomarkers (current)

    Student name:
    MRes
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • Investigation of Candida diversity in an infertile cohort using next generation genetic analysis (current)

    Student name:
    PhD
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Prof Paul Dyson
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Peter Dunstan
    Other supervisor: Prof Catherine Thornton
  • Combining regenerative medicine strategies to tissue engineer cartilage for facial reconstruction (current)

    Student name:
    PhD
    Other supervisor: Prof Iain Whitaker
    Other supervisor: Prof Catherine Thornton
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Ruth Godfrey
    Other supervisor: Prof Catherine Thornton
  • The development of a solid-state hMeDIP assay for epigenetic analysis of neural stem cell function - implications for dementia (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • Exploring metabolomic biomarkers using mass spectrometry. (current)

    Student name:
    PhD
    Other supervisor: Dr Ed Dudley
    Other supervisor: Prof Catherine Thornton
  • Inhibiting IL-17 Production by Blocking Endogenous RORγt Agonists for the Treatment of Autoimmune Diseases (current)

    Student name:
    PhD
    Other supervisor: Dr Yuqin Wang
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof William Griffiths
    Other supervisor: Prof Catherine Thornton
  • Investigating novel small molecule enzyme inhibitors for treating cognitive decline and dementia (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • Preventing nerve cell loss in Alzheimer's disease: a role for the orexigenic hormone ghrelin? (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • The role of neuronal autophagy in ghrelin mediated neuroprotection and neurogenesis: Implications for dementia and associated disease (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Catherine Thornton
    Other supervisor: Dr Alwena Morgan
  • Effects of bariatric weight loss on asthma and inflammatory phenotypes (current)

    Student name:
    MD
    Other supervisor: Dr Gwyneth Davies
    Other supervisor: Prof Catherine Thornton