Publications

Journal Articles

  1. & Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science, jcs.191643
  2. & Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating. Scientific Reports 6(1)
  3. & Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology 173(15), 2446-2459.
  4. & Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology 594(21), 6431-6432.
  5. & Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research 105(1), 118-128.
  6. & The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2. Circulation Research 116(8), 1324-1335.
  7. & Insights into the Gating Mechanism of the Ryanodine-Modified Human Cardiac Ca2+-Release Channel (Ryanodine Receptor 2). Molecular Pharmacology 86(3), 318-329.
  8. & N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science 126(21), 5042-5051.
  9. & Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating. Journal of Biological Chemistry 288(23), 16671-16679.
  10. & A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment. The Journal of General Physiology 140(2), 139-158.
  11. & Pharmacology of ryanodine receptors and Ca2+-induced Ca2+ release. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1(4), 383-397.
  12. & Calcium Signaling. Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level Chapter 8, 183-215.
  13. & Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction. FEBS Letters 584(10), 2153-2160.
  14. & FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal 419(2), 273-278.
  15. & Alternative Splicing of Ryanodine Receptors Modulates Cardiomyocyte Ca2+ Signaling and Susceptibility to Apoptosis. Circulation Research 100(6), 874-883.
  16. & Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochemical Society Transactions 35(5), 946-951.
  17. & Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies. Journal of Molecular and Cellular Cardiology 42(1), 34-50.
  18. & Arrhythmogenic Mutation-Linked Defects in Ryanodine Receptor Autoregulation Reveal a Novel Mechanism of Ca2+ Release Channel Dysfunction. Circulation Research 98(1), 88-97.
  19. & Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?. Biochemical Society Transactions 34(5), 913-918.
  20. & Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiology 1(4), 531-541.
  21. & Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochemical and Biophysical Research Communications 331(1), 231-238.
  22. & Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovascular Research 64(1), 52-60.
  23. & Ryanodine Receptor Regulation by Intramolecular Interaction between Cytoplasmic and Transmembrane Domains. Molecular Biology of the Cell 15(6), 2627-2638.