About Me

Professor Sheldon is a researcher and veterinarian with an interest in the fundamental molecular mechanisms of infection and immunity. Professor Sheldon was in clinical practice for 14 years before moving to London, where he developed his research interests and was awarded his PhD in 2002. In 2006 he won a BBSRC Research Development Fellowship and in 2008 Professor Sheldon established a laboratory at the College of Medicine. My Department is ranked 2nd in the UK for research on subjects allied to health (REF 2014; 2nd out of 94).

Professor Sheldon is interested in the mechanisms of infection and innate immunity in the female genital tract. Microbial infection of the female genital tract is a major disease problem in animals and humans, with a substantial impact on health and welfare. With BBSRC funding, Professor Sheldon and his team explore the cellular mechanisms of innate immunity, inflammation and microbial infection that apply across species. Professor Sheldon discovered novel bacteria that cause metritis and endometritis, which are important disease of the uterus in cattle. In addition, he has uncovered mechanisms that explain how these microbes cause inflammation and tissue damage in the endometrium of the uterus, and in the ovary. One of the key discoveries by Professor Sheldon was that the epithelial and stromal cells of the endometrium, and granulosa cells of the ovary have roles in innate immunity. In particular they express receptors, such as Toll-like Receptors (TLRs), which detect pathogen-associated molecular patterns to induce an inflammatory response including the production of cytokines, chemokines and prostaglandins. Furthermore, pathogen-associated molecules even perturb oocyte health and development, linking bacterial infections to long-term impacts on fertility.

A clinical background coupled with exploring the basic science of infection and immunity, has provided Professor Sheldonwith a unique perspective. In 2013, Professor Sheldon's research was recognised by the award of FRCVS.

Areas of Expertise

  • Innate immunity
  • Reproductive Biology

Publications

  1. & Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology
  2. & Mevalonate biosynthesis intermediates are key regulators of innate immunity in bovine endometritis. Journal of Immunology 196
  3. & Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium. PLOS ONE 11(e0151416), 1-20.
  4. & Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. The FASEB Journal 29(4), 1516-1528.
  5. & Epithelial and Stromal Cells of Bovine Endometrium Have Roles in Innate Immunity and Initiate Inflammatory Responses to Bacterial Lipopeptides In Vitro via Toll-Like Receptors TLR2, TLR1, and TLR6. Endocrinology 155(4), 1453-1465.
  6. & Tethered bilayer membranes as a complementary tool for functional and structural studies: The pyolysin case. Biochimica et Biophysica Acta (BBA) - Biomembranes
  7. & Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1. Scientific Reports 4, 7060
  8. & A three-dimensional model of primary bovine endometrium using an electrospun scaffold. Biofabrication 7(2), 025010
  9. & Differential Endometrial Cell Sensitivity to a Cholesterol-Dependent Cytolysin Links Trueperella pyogenes to Uterine Disease in Cattle. Biology of Reproduction 90(3), 54-54.
  10. & Genomic characterisation of an endometrial pathogenic Escherichia coli strain reveals the acquisition of genetic elements associated with extra-intestinal pathogenicity. BMC Genomics 15(1), 1075

See more...

Teaching

  • PM-304 Biomolecular Research Project

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  • PMLM06 LC/MS Applications V: Metabolomics, Lipidomics and Bioactive lipids

    This module covers the basic concepts of metabolomics, lipidomics and analysis of bioactive lipids. The module will focus on the application of LC-MS analysis of biomolecules isolated from complex mixtures.

Supervision

  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Professor Martin Sheldon
    Other supervisor: Dr James Cronin
  • Mechanisms of host-pathogen interactions and innate immunity between the bovine endometrium and Trueperella pyogenes (current)

    Student name:
    PhD
    Other supervisor: Professor Martin Sheldon
    Other supervisor: Professor Samuel Sheppard
  • 'Pattern recognition receptor activity at the maternal-fetal interface: implications for pre-term labour' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Professor Catherine Thornton
    Other supervisor: Professor Martin Sheldon
  • 'The Role of Innate Immunity in the Host Response to Pathogens and Damage in the Endometrium' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Professor Martin Sheldon
    Other supervisor: Professor Catherine Thornton
  • '''''Immunomodulatory effects of probiotics''''' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Professor Gareth Morgan
    Other supervisor: Professor Martin Sheldon
  • 'Mechanisms underlying the effect of infection and inflammation on ovarian health' (awarded 2013)

    Student name:
    PhD
    Other supervisor: Professor Martin Sheldon
    Other supervisor: Professor Venkat Kanamarlapudi
  • 'The effect of bacterial pathogen-associated molecular patterns and metabolism on innate immunity in the bovine endometrium' (awarded 2013)

    Student name:
    PhD
    Other supervisor: Professor Martin Sheldon
    Other supervisor: Professor Steve Conlan