Publications

Journal Articles

  1. & The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy 61(7), e00333-17
  2. & Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.00651-17
  3. et. al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy 61(5), e02280-16
  4. & Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3: Genes|Genomes|Genetics
  5. & The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy 60(8), 4530-4538.
  6. & Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports 6, 27690
  7. & Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science 71(8), 1054-1058.
  8. In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 59(12), 7771-7778.
  9. & Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.
  10. & Multidrug transporters and alterations in sterol biosynthesis contribute to azole antifungal resistance inCandida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.01358-15
  11. & Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology
  12. & Azole antifungal agents to treat the human pathogensAcanthamoeba castellanii and Acanthamoeba polyphagathrough inhibition of sterol 14α-demethylase (CYP51). Antimicrobial Agents and Chemotherapy, AAC.00476-15
  13. et. al. Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology 80(19), 6154-6166.
  14. & Resistance to antifungals that target CYP51. Journal of Chemical Biology 7(4), 143-161.
  15. et. al. The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.
  16. & Azole Affinity of Sterol 14 -Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy 57(3)-1360.
  17. & Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14- -Demethylase. Applied and Environmental Microbiology 79(5)-1645.
  18. & Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist-n/a.
  19. & Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy 57(7)-3193.
  20. & Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE 8(6)
  21. & Azole resistance by loss of function of the sterol  5,6-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence. Antimicrobial Agents and Chemotherapy
  22. & S279 Point Mutations in Candida albicans Sterol 14-  Demethylase (CYP51) Reduces in vitro Inhibition by Fluconazole.. Antimicrobial Agents and Chemotherapy
  23. & Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy 56(8)-4232.
  24. & Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2. Antimicrobial Agents and Chemotherapy 56(12)-6421.
  25. & Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola. PLoS ONE 6(6), e20973
  26. & Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology 77(11), 3830-3837.
  27. & Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology 102(2), 1503-1508.
  28. & Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals. Applied and Environmental Microbiology 77(4), 1460-1465.
  29. & Azole Binding Properties of Candida albicans Sterol 14-  Demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy 54(10), 4235-4245.
  30. & A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14 -Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy 54(9), 3578-3583.
  31. & Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14 alpha-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B. Antimicrobial Agents and Chemotherapy 54(11), 4920-4923.
  32. & Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-  Demethylase (CYP51) Isoenzymes A and B. Antimicrobial Agents and Chemotherapy 54(10), 4225-4234.
  33. & Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans. Antimicrobial Agents and Chemotherapy 54(11), 4527-4533.
  34. & Heterologous Expression of Mutated Eburicol 14α -Demethylase (CYP51) Proteins of Mycosphaerella graminicola To Assess Effects on Azole Fungicide Sensitivity and Intrinsic Protein Function. Applied and Environmental Microbiology 76(9), 2866-2872.
  35. & Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresource Technology 101(12), 4395-4402.
  36. & Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae. Antimicrobial Agents and Chemotherapy 53(3), 1157-1164.
  37. & Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14 alpha-Demethylase at the Homologous Locus. Antimicrobial Agents and Chemotherapy 52(10), 3597-3603.
  38. & Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis. Biochemical and Biophysical Research Communications 301(2), 558