Publications

  1. & Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes. mSphere 2(5), e00379-17
  2. & Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.00651-17
  3. & The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy 61(7), e00333-17
  4. et. al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy 61(5), e02280-16
  5. & Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3: Genes|Genomes|Genetics
  6. & The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy 60(8), 4530-4538.
  7. & Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports 6, 27690
  8. & Multidrug transporters and alterations in sterol biosynthesis contribute to azole antifungal resistance inCandida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.01358-15
  9. & Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology
  10. & Azole antifungal agents to treat the human pathogensAcanthamoeba castellanii and Acanthamoeba polyphagathrough inhibition of sterol 14α-demethylase (CYP51). Antimicrobial Agents and Chemotherapy, AAC.00476-15
  11. & Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science 71(8), 1054-1058.
  12. In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 59(12), 7771-7778.
  13. & Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.
  14. et. al. Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology 80(19), 6154-6166.
  15. & Resistance to antifungals that target CYP51. Journal of Chemical Biology 7(4), 143-161.
  16. et. al. The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.
  17. & Azole Affinity of Sterol 14 -Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy 57(3)-1360.
  18. & Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14- -Demethylase. Applied and Environmental Microbiology 79(5)-1645.
  19. & Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist-n/a.
  20. & Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy 57(7)-3193.
  21. & Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE 8(6)
  22. & Azole resistance by loss of function of the sterol  5,6-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence. Antimicrobial Agents and Chemotherapy
  23. & S279 Point Mutations in Candida albicans Sterol 14-  Demethylase (CYP51) Reduces in vitro Inhibition by Fluconazole.. Antimicrobial Agents and Chemotherapy
  24. & Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy 56(8)-4232.
  25. & Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2. Antimicrobial Agents and Chemotherapy 56(12)-6421.
  26. & Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola. PLoS ONE 6(6), e20973
  27. & Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology 77(11), 3830-3837.
  28. & Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology 102(2), 1503-1508.
  29. & Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals. Applied and Environmental Microbiology 77(4), 1460-1465.
  30. & Azole Binding Properties of Candida albicans Sterol 14-  Demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy 54(10), 4235-4245.

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Teaching

  • PM-120 Genetic Analysis I

    This module will give assignments designed to develop skills in essay writing and oral presentations. It will also look at the principles and practice of internet searching for scientific sources.

  • PM-200 Genetic Analysis II

    This module will give assignments designed to build on essay writing and oral presentation skills introduced in level 1. It will also develop critical evaluation, analysis skills for the understanding of peer-reviewed research papers.

  • PM-250 Infectious Disease and Parasitology

    The course will build on the fundamentals of microbiology and introduce new topics in bacteriology, mycology and parasitology. Level 5 Immunology (PM-249) is a pre-requisite. The course covers the fundamentals of infectious diseases, including clinical aspects, treatment / prevention, and experimental approaches to the study of infectious and parasitic organisms. The course will also cover topics including disease outbreaks, beneficial parasites, tropical disease and behaviour-modifying parasites.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

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  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.