Professor David Lamb
Professor
Medicine
Telephone: (01792) 602178
Room: Academic Office - 505
Fifth Floor
Institute of Life Science 1
Singleton Campus

Publications

  1. & Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  2. & Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and Applied Pharmacology 296, 73-84.
  3. & Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. Molecular Phylogenetics and Evolution 94, 676-687.
  4. & Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) fromAspergillus fumigatusand Molecular Basis for the Development of Antifungal Drugs. Journal of Biological Chemistry 290(39), 23916-23934.
  5. & Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrobial Agents and Chemotherapy 59(8), 4707-4713.

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Teaching

  • PMGM12 Omics Techniques and their Application to Genomic Medicine

    This module explores the state of the art genomics techniques used for DNA sequencing (e.g. targeted approaches, whole exome and whole genome sequencing) and RNA sequencing. This module will include introductory bioinformatics approaches required for the analysis of genomic data, which will provide a solid foundation for the Bioinformatics module. The module will also cover the use of array based methodologies and RNA sequencing in estimating levels of protein expression, micro RNAs and gene manipulation technologies. A comprehensive introduction to metabolomics and proteomics, which are important for the functional interpretation of genomic data and discovery of disease biomarkers will also be included.