Publications

Journal Articles

  1. & Co‑production of 11α‑hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases. Biotechnology for Biofuels 10
  2. & The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy 61(7), e00333-17
  3. et. al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy 61(5), e02280-16
  4. & Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes. mSphere 2(5), e00379-17
  5. & Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, AAC.00651-17
  6. & The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy 60(8), 4530-4538.
  7. & Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3 Genes|Genomes|Genetics 6(11)
  8. & Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports 6, 27690
  9. & CYP51-mediated Azole Resistance inAspergillus fumigatus: an in vitro Biochemical Study. Antimicrobial Agents and Chemotherapy, AAC.01806-15
  10. & Multidrug transporters and alterations in sterol biosynthesis contribute to azole antifungal resistance in Candida parapsilosis.. Antimicrob.Ag.Chemother. 59
  11. & Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology
  12. & Azole antifungal agents to treat the human pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through inhibition of sterol 14α-demethylase (CYP51).. Antimicrob.Ag.Chemother.
  13. & Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens.. Pest.Manag.Sci
  14. & Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.
  15. & Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology 80(19), 6154-6166.
  16. & Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept. AMB Express 4(1), 64-72.
  17. & Paralog re-emergence: a novel, historically contingent mechanism in the evolution of antimicrobial resistance. Mol Biol Evol. 31(7), 1792-1802.
  18. & Use of 70% alcohol for the routine removal of microbial hard surface bioburden in life science cleanrooms. Future Microbiology 9(10), 1123-1130.
  19. & Resistance to antifungals that target CYP51. Journal of Chemical Biology 7(4), 143-161.
  20. & Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock. Biotechnology for Biofuels 7(1), 133
  21. & The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.
  22. & Alterations in the predicted regulatory and coding regions of the sterol 14α-demethylase gene (CYP51) confer decreased azole sensitivity in the oilseed rape pathogen Pyrenopeziza brassicae.. Mol Plant Pathol. 15(5), 513-522.
  23. Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans.. J Antimicrob Chemother. 2013 Jan 7. [Epub ahead of print]
  24. & Functional and structural characterisation of a viral cytochrome b5. FEBS Letters 587(22), 3633-3639.
  25. & The cytochrome P450 complement (CYPome) of Mycosphaerella graminicola. Biochemistry and Applied Biotechnology 60(1)-64.
  26. & Azole Affinity of Sterol 14-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy 57(3), 1352-1360.
  27. & An algorithm for rapid computational construction of metabolic networks: A cholesterol biosynthesis example. Computers in Biology and Medicine 43(5), 471-480.
  28. & Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-demethylase. Applied and Environmental Microbiology 79(5), 1639-1645.
  29. & Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist 198(3)-835.
  30. & Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE 8(6)
  31. & Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy 57(7), 3182-3193.
  32. & Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?. Philosophical Transactions of the Royal Society B: Biological Sciences 368(1612), 20120476-20120476.
  33. & Two clinical isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2.. Antimicrob Agents Chemother. 2012 Oct 1. [Epub ahead of print]
  34. & Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.. Antimicrob Agents Chemother. 2012 Aug;56(8):4223-32. May 21. [Epub ahead of print] 56, 4223-4232.
  35. & S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole.. Antimicrob.Agents.Chemother. 56(4), 2099-2107.
  36. & Azole Resistance by Loss of Function of the Sterol {Delta}5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence.. Antimicrob.Agents.Chemother. 56(4), 1960-1968.
  37. & Triclosan anatagonizes fluconazole activity against candida albicans. Journal of Dental Research 91(1), 65-70.
  38. & An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae. Antimicrobial Agents and Chemotherapy 56(1), 391-402.
  39. & Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.. FEBS J. 279(9), 1640-1649.
  40. & Structural Analysis of Cytochrome P450 105N1 Involved in the Biosynthesis of the Zincophore, Coelibactin.. Int J Mol Sci. 2012;13(7):8500-13. 13, 8500-8513.
  41. & Impact of Recently Emerged Sterol 14 -Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology 77(11), 3830-3837.
  42. & Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.. Appl Environ Microbiol 77(4), 1460-5.
  43. Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology 102(2), 1503-1508.
  44. & Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola.. PLoS One 6(6), e20973
  45. & Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol.. Bioresour Technol 102(2), 1503-8.
  46. & Cyclization of a Cellular Dipentaenone byStreptomyces coelicolorCytochrome P450 154A1 without Oxidation/Reduction. Journal of the American Chemical Society 132(43), 15173-15175.
  47. & Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14¦Á-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.. Antimicrob Agents Chemother. 54(11), 4920-3.
  48. & Expression, purification and use of the soluble domain of Lactobacillus paracasei beta-fructosidase to optimise production of bioethanol from grass fructans.. Bioresour Technol. 101(12), 4395-402.
  49. & Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. Appl Environ Microbiol. 76(6), 1975-80.
  50. & Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.. Antimicrobial Agents and Chemotherapy 54(11), 4920-3.
  51. & Identification and characterisation of four azole-resistant erg3 mutants of Candida albicans. Antimicrobial Agents and Chemotherotherapy 54(11), 4527-33.
  52. & Expression, purification and characterisation of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrobial Agents and Chemotherapy. 54(10), 4225-34.
  53. & Azole Binding Properties of Candida albicans Sterol 14-alpha Demethylase (CaCYP51). Antimicobial Agents and Chemotherapy 54(10), 4235-45.
  54. & A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14 alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.. Antimicrobial Agents and Chemotherapy. 54(9), 3578-83.
  55. & Heterologous expression of mutated eburicol 14 alpha-demethylase (CYP51) proteins of Mycosphaerella gramminicola to assess effects on azole fungicide sensitivity and intrinsic protein function.. Applied and Environmental Microbiology. 76(9), 2866-2872.
  56. & The first virally encoded cytochrome P450. J Virol 83(16), 8266-9.
  57. & Identification, characterisation, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobaterium leprae.. Antimicrob agents Chemother. 53(3), 1157-64.
  58. & Crystal structure of albaflavenone monoxygenase containing a moonlighting terpene synthase active site.. J Biol Chem 284(52), 36711-9.
  59. & Molecular characterisation of a subgroup IE intron with wide distribution in the large subunit rRNA genes of dermatophyte fungi. Med Mycol. 47(6), 609-17.
  60. & Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. Antimicrob Agents Chemother. 52(10), 3597-603.
  61. & CYP56(Dit2p) in Candida albicans: characterisation and investigation of its role in growth and antifungal drug susceptibility. Antimicrob Agents Chemother. 52(10), 3718-24.
  62. & 1-[(3-Aryloxy-3-aryl)propyl]-1 H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatohytes. Synthesis, structure-activity relationship, and molecular modelling studies.. J Med Chem 51(13), 3841-55.
  63. & Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J Biol Chem. 203(12), 8183-9.
  64. & Expression of human cytochrome p450 3A4 gene in Schizosaccharomyces pombe. Biologia 63(1), 450-454.