Publications

Journal Articles

  1. et. al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy 61(5), e02280-16
  2. & The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy, AAC.00333-17
  3. & The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy 60(8), 4530-4538.
  4. & Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports 6(1)
  5. & Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrobial Agents and Chemotherapy 59(8), 4707-4713.
  6. & Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.
  7. & Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science 71(8), 1054-1058.
  8. & In VitroBiochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 59(12), 7771-7778.
  9. & Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock. Biotechnology for Biofuels 7(1), 133
  10. & Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept. AMB Express 4(1), 64
  11. & Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology 80(19), 6154-6166.
  12. & Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance. Molecular Biology and Evolution 31(7), 1793-1802.
  13. & The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.
  14. & Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14- -Demethylase. Applied and Environmental Microbiology 79(5)-1645.
  15. & Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?. Philosophical Transactions of the Royal Society B: Biological Sciences 368(1612)-20120476.
  16. & The cytochrome P450 complement (CYPome) ofMycosphaerella graminicola. Biotechnology and Applied Biochemistry 60(1), 52-64.
  17. & Azole Affinity of Sterol 14 -Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy 57(3), 1352-1360.
  18. & An algorithm for rapid computational construction of metabolic networks: A cholesterol biosynthesis example. Computers in Biology and Medicine 43(5)-480.
  19. & Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE 8(6)
  20. & Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2. Antimicrobial Agents and Chemotherapy 56(12)-6421.
  21. & Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy 56(8)-4232.
  22. & S279 Point Mutations in Candida albicans Sterol 14-  Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole. Antimicrobial Agents and Chemotherapy 56(4), 2099-2107.
  23. & Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology 102(2)-1508.
  24. & Impact of Recently Emerged Sterol 14 -Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology 77(11), 3830-3837.
  25. & Moleuclar modelling of the emergence of azole resistance in Mycosphaerella garminicola.. PLoS One, e20973
  26. & Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresource Technology 101(12)-4402.
  27. & Complementation of Saccharomyces cerevisiae ERG11/CYP51 regulated mutant and screening the azole sensitivity of Aspergillus fumigatus CYP51A and B.. Antimicrob Agents Chemother., 4920-4923.
  28. & Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-  Demethylase (CYP51) Isoenzymes A and B. Antimicrobial Agents and Chemotherapy 54(10), 4225-4234.
  29. & A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14 -Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy 54(9), 3578-3583.
  30. & Azole Binding Properties of Candida albicans Sterol 14-  Demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy 54(10), 4235-4245.
  31. & Cyclization of a Cellular Dipentaenone byStreptomyces coelicolorCytochrome P450 154A1 without Oxidation/Reduction. Journal of the American Chemical Society 132(43), 15173-15175.
  32. & The CYPome (Cytochrome P450 complement) of Aspergillus nidulans. Fungal Genetics and Biology 46(1), S53-S61.
  33. & Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1157-1164.
  34. & Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14 -Demethylase at the Homologous Locus. Antimicrobial Agents and Chemotherapy 52(10), 3597-3603.
  35. & CYP56 (Dit2p) in Candida albicans: Characterization and investigation of its role in growth and antifungal drug susceptibility. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 3718-3724?.
  36. & Lanosterol Biosynthesis in the Prokaryote Methylococcus Capsulatus: Insight into the Evolution of Sterol Biosynthesis. Molecular Biology and Evolution 24(8), 1714-1721.
  37. et. al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896), 387-391.
  38. A Novel Sterol 14alpha -Demethylase/Ferredoxin Fusion Protein (MCCYP51FX) from Methylococcus capsulatus Represents a New Class of the Cytochrome P450 Superfamily. Journal of Biological Chemistry 277(49), 46959-46965.
  39. The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2). Journal of Biological Chemistry 277(27), 24000-24005.