Areas of Expertise

  • sterol metabolism
  • Microbial cytochromes P450 (CYP's)
  • Microbial Resistance

Publications

  1. & In VitroBiochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 59(12), 7771-7778.
  2. & Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology 81(10), 3379-3386.
  3. & Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science 71(8), 1054-1058.
  4. & Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrobial Agents and Chemotherapy 59(8), 4707-4713.
  5. & The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy 58(12), 7121-7127.

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Supervision

  • 'The Role of Cytochrome P450 and ABC Transporters in M. graminicola Antifungal Resistance' (awarded 2013)

    Student name:
    PhD
    Other supervisor: Prof Steven Kelly
    Other supervisor: Prof Diane Kelly
  • 'A study of fungal genes related to dityrosine biosynthesis: using a bioinformatic and molecular biological approach.' (awarded 2013)

    Student name:
    MPhil
    Other supervisor: Prof Diane Kelly
    Other supervisor: Dr Jonathan Mullins
  • Candida CYP52: ALkane and Fatty Acid Metabolism (awarded 2012)

    Student name:
    PhD
    Other supervisor: Prof Steven Kelly
    Other supervisor: Prof Diane Kelly
  • Fungal azole resistance and the role of cytochrome P450 (awarded 2007)

    Student name:
    PhD
    Other supervisor: Prof Steven Kelly
    Other supervisor: Prof Diane Kelly