Professor Venkat Kanamarlapudi

Professor Venkat Kanamarlapudi
Professor of Molecular Cell Biology
Medicine
Telephone: (01792) 295012
Room: Academic Office - 204
Second Floor
Institute of Life Science 1
Singleton Campus

Areas of Expertise

  • Cell Biology
  • Cell Signalling
  • Molecular Mechanisms of disease
  • Biochemistry
  • Molecular Biology
  • Diabetes
  • Cancer
  • Host pathogen interactions
  • Phagocytosis
  • Membrane trafficking
  • Drug discovery
  • Endocytosis
  • Glucagon like peptide-1 (GLP-1)
  • Arf6
  • G protein coupled receptor (GPCR)
  • Neuroscience

Publications

  1. & Exclusion of Integrins from CNS Axons Is Regulated by Arf6 Activation and the AIS. Journal of Neuroscience 35(21), 8359-8375.
  2. & EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment. Journal of Cell Science 130(21), 3663-3675.
  3. Exchange factor EFA6R requires C-terminal targeting to the plasma membrane to promote cytoskeletal rearrangement through the activation of ARF6. Journal of Biological Chemistry 289(48), 33378-33390.
  4. & The regions within the N-terminus critical for human glucagon like peptide-1 receptor (hGLP-1R) cell Surface expression. Scientific Reports 4, 7410
  5. & Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gαq pathway. Biochemical Pharmacology 93(1), 72-84.

See more...

Teaching

  • PM-304 Biomolecular Research Project

    *

  • PM-331 Membrane Trafficking

    The module provides an understanding of the subcellular organelles, the regulation of their biosynthesis and how impairment of this process leads to disease.

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PMLM05 LC/MS Applications IV: Medical and life sciences

    Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.

Supervision

  • Analysis of the effect of mechanical heart pumps on the blood components (current)

    Student name:
    PhD
    Other supervisor: Dr Karl Hawkins
    Other supervisor: Prof Venkat Kanamarlapudi
  • Functional characterisation of EFA6R, a possible biomarker for ovarian cancer. (current)

    Student name:
    PhD
    Other supervisor: Dr William Walker
    Other supervisor: Prof Venkat Kanamarlapudi
  • Investigating a sterol oxdiase CYP in Mycobacterium abscessus (current)

    Student name:
    MSc
    Other supervisor: Prof Venkat Kanamarlapudi
    Other supervisor: Prof Diane Kelly
  • Studying the underlying mechanisms of the GLP-1 receptor agonists treatment for diabesity«br /» (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Bain
    Other supervisor: Prof Venkat Kanamarlapudi
  • Targeting the interleukin-13 receptor (IL-13R)alpha2 expressing pancreatic cancer by a novel hybrid lytic peptide drug (current)

    Student name:
    PhD
    Other supervisor: Dr William Walker
    Other supervisor: Prof Venkat Kanamarlapudi
  • Molecular mechanism of Arf6 small GTPase inhibition in treating multidrug resistant bacterial infections (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
    Other supervisor: Prof Venkat Kanamarlapudi
  • Modelling Dynamic Cooperativity, Oligomerisation And Allosterism For G-Protein Coupled Receptors (current)

    Student name:
    PhD
    Other supervisor: Prof Venkat Kanamarlapudi
    Other supervisor: Dr Gibin Powathil
  • Analysis of Mechanisms Involved in Ventricular Assist Device (VAD) Induced Extracellular Vesicles Generation and their Cellular Effects«br /» (current)

    Student name:
    PhD
    Other supervisor: Dr Ankush Aggarwal
    Other supervisor: Prof Venkat Kanamarlapudi