Dr Matthew Hitchings
Research Officer
Swansea University Medical School
Telephone: (01792) 295028
Email: JavaScript is required to view this email address.

Publications

  1. et. al. Recombination-Mediated Host Adaptation by Avian Staphylococcus aureus. Genome Biology and Evolution 9(4), 830-842.
  2. & Local genes for local bacteria: evidence of allopatry in the genomes of transatlantic Campylobacter populations. Molecular Ecology
  3. & Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports 7, 42471
  4. & Large sequence diversity within biosynthesis locus and common biochemical features ofCampylobacter colilipooligosaccharides. Journal of Bacteriology, JB.00347-16
  5. & From Escherich to the Escherichia coli genome. The Lancet Infectious Diseases 16(6), 634-636.

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Teaching

  • PM-248 Amino acids, lipids and steroids

    The module reviews the pathways of fatty acid degradation (beta-oxidation) before describing the biochemistry of the multi-functional proteins that catalyse the formation of fatty acids. The mechanisms of fatty acid elongation and desaturation are covered along with the synthesis of triacylglycerols and glycerophospholipids with consideration being being given to the control of these pathways. The synthesis of cholesterol via the mevalonate pathway is described along with the various metabolic control points and an understanding of dietary lipid transport. The further metabolism of cholesterol to bile salts, steroid hormones and vitamin D is outlined with consideration given to the stereochemistry of these compounds. The module provides a sound basis for understanding the metabolism of amino acids, lipids and steroids. The pathways of amino acid synthesis and degradation in humans are described along with an introduction to the urea cycle.

  • PM-304 Biomolecular Research Project

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  • PM-345 Bioinformatics: From sequence to Function

    The ever increasing availability of genome sequences and protein structure data demands that molecular biologists are proficient at performing extensive data analyses to guide and support traditional laboratory-based research. This Module will provide the theoretical basis and practical training on computational tools currently used to assemble and interrogate genome sequences, infer gene and protein functions, and to examine protein structure data.

  • PMNM06 Bioinformatics

    This module will provide a general introduction to the mainstream techniques and applications of bioinformatics. The student will be introduced to the concepts of acquiring and analysing biomolecular data using public resources and tools with a focus on nanomedicine.The student will also be taught basic programming skills which are fundamental to bioinformatics