Professor Christopher George

Chris was born and brought up in the Cynon Valley and studied Biochemistry at Cardiff University. After a PhD investigating the role of calcium signals in regulating cell-to-cell communication, Chris moved into heart research at Cardiff University’s Medical School. Keen to take responsibility for his own mistakes, Chris got a British Heart Foundation Intermediate Fellowship in 2000. Successive BHF Lectureship and Senior Basic Science Research Fellowship awards between 2004 and 2015 funded him to combine new molecular and cellular imaging tools with network theory to explore the links between calcium signaling, cellular behavior and the early events leading to the destruction of normal heart rhythm. As a member of the Molecular Cardiology group, Chris became a Professor at Swansea University’s Medical School in 2017. His research is now focused on investigating the mechanisms that underpin the variability and predictability of response of populations of stem-cell derived heart cells to genetic mutations and drugs. The work will improve therapeutic approaches for tackling genetic and acquired heart disease and is also being incorporated into new frameworks for early drug screening and drug development. He is a Senior Editor of the British Journal of Pharmacology and is a member of the editorial board of Frontiers in Physiology and Artery Research. Chris currently serves on the grants assessment panel for the National Centre for Replacement, Refinement and Reduction of Animals in Research (NC3R). 

Areas of Expertise

  • Calcium signalling
  • Genetic and acquired arrhythmias
  • Cardiac stem cells
  • Cardiovascular biology
  • Cellular and molecular biology
  • Systems biology
  • Cell imaging

Publications

  1. & The ryanodine receptor: advances in structure and organization. Current Opinion in Physiology 1C, 1-6.
  2. & Decoding Ca2+ signals as a non-electrophysiological method for assessing drug toxicity in stem cell-derived cardiomyocytes. In Stem Cell-derived models in toxicology. (pp. 173-190).
  3. & Ryanodine receptors are part of the myospryn complex in cardiac muscle. Scientific Reports 7(1)
  4. & Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. British Journal of Pharmacology 174(17), 2801-2804.
  5. & Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart. JACC: Clinical Electrophysiology 3(7), 703-714.

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Teaching

  • PM-257 Neuroscience

    In order to help students understand the biological basis for behavioural neuroscience and neurological disorders, this module seeks to integrate the multidisciplinary sciences ¿ for example, anatomy, physiology and biochemistry - that have combined to build the emerging field of neuroscience. The aim is to gain a mechanistic and holistic knowledge of the nervous system that builds from the molecular, cellular and developmental, to the systems level. In addition to exploring normal function, this module will introduce common disorders of the central and peripheral nervous systems in an integrated way. Students will be guided in exploring the scientific evidence around what is known and unknown and will be introduced to current research findings in the scientific literature.