Dr Jezabel Garcia Parra
Research Officer
Swansea University Medical School
Telephone: (01792) 513400

Jezabel’s research focuses on the study of novel cancer biomarkers and the development of advanced therapeutics in precision medicine. Her clinical interests are mainly gynaecological (ovarian, endometrial and cervical cancer) and breast cancers. Her scientific career has been always connected to translational medicine and her aim is to contribute improving cancer treatments through preclinical research.

Areas of Expertise

  • Cancer
  • Molecular biology
  • Drug development
  • Biomarker research
  • Reproductive biology

Publications

  1. & Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment. Interface Focus 6(6), 20160054
  2. & Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer. European Journal of Cancer 50(15), 2725-2734.
  3. & Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. Annals of Oncology 23(5), 1156-1164.

Teaching

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Research Groups

Career History

Start Date End Date Position Held Location
2014 Present Researcher Reproductive Biology and Gynecological Oncoloy Research Group, Swansea University Medical School
2006 2012 Research Assistant and PhD Student Barcelona Biomedical Research Park

Key Grants and Projects

  • SMARTExpertise 2018 - 2020

    RISE: ReNeuron, IgInnovations and Swansea University development of Exosomes towards clinical utility

  • Life Science Bridging Fund, AgorIP 2014

    SNIPER ADC development for gynaecological cancers

  • Life Science Research Network Wales 2017 - 2018

    ADC targets from in-silico high-throughput screening identification into target validation