I studied both my BSc and MSc in Biomedical Science in University of Wales Institute, Cardiff, specialising in Forensic Toxicology and Medical Microbiology. Following this I was fortunate enough to be awarded a NISCHR Welsh Office of Research and Development PhD (2009), investigating the role of exercise in preventing the progression of Type 2 diabetes and associated cardiovascular effects e.g. atherosclerosis and cell polarisation effects. This allowed me the opportunity to carry out in vivo projects and develop a keen interest in the effects of inflammation on cell signalling pathways and their role in disease progression.

My time as a post-Doctoral researcher was spent in the Haemostasis Biomedical Research Unit, investigating the role of inflammation in haemostasis and how this varies in hypo- and hyper-coagulable states. Based in an Emergency Department in Morriston Hospital, I developed a keen interest in Emergency Medicine Research and was involved in a number of studies investigating the role of haemostasis in stroke, cardiac, sepsis and burns patients. I successfully led and completed a project investigating the changes in haemostasis in patients with lung cancer, quantifying changes to clot structure using a cutting edge haemorheological technique, developed here in Swansea University between Medical School and the College of Engineering.

My current role as a lecturer allows me to combine my research experience and knowledge with teaching. I am module co-ordinator on the Applied Medical Sciences Degree and am developing a Foundation in Applied Medical Sciences, to commence in September 2017, to widen access to Higher Education in Medical Sciences.

Publications

  1. Fractal dimension (df) as a new structural biomarker of clot microstructure in different stages of lung cancer. Thrombosis and Haemostasis 114(6), 1251-1259.
  2. Exercise-induced immunosuppression: roles of reactive oxygen species and 5'-AMP-activated protein kinase dephosphorylation within immune cells. Journal of Applied Physiology 108(5), 1284-1292.
  3. Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thrombosis Research 135(6), 1075-1080.
  4. The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells. Free Radical Research 49(1), 45-56.
  5. Exercise-associated generation of PPAR  ligands activates PPAR  signaling events and upregulates genes related to lipid metabolism. Journal of Applied Physiology 112(5), 806-815.

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Teaching

  • PM-138 Skills for Medical Sciences

    The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.

  • PM-138C Sgiliau ar gyfer Gwyddorau Meddygol

    Nod y modiwl hwn yw darparu¿r sgiliau sylfaenol sydd eu hangen ar fyfyrwyr ar gyfer ymchwil labordy ym maes y gwyddorau meddygol cymhwysol. Bydd y modiwl yn cynnwys gwaith damcaniaethol a chymhwysol: caiff y myfyriwr ei hyfforddi mewn dulliau sy¿n hanfodol ar gyfer caffael data a¿i ddadansoddi, ond bydd hefyd yn cymryd rhan weithredol yn y labordy, gan ddefnyddio¿n fras y technegau arbrofol perthnasol. Byddant hefyd yn datblygu sgiliau nad ydynt yn dechnegau arbrofol yn eu hunain, ond sydd er hynny, yn sylfaenol i¿r broses wyddonol, megis, mathemateg y labordy¿, cyrchu gwybodaeth, cyfeirnodi, moeseg ac iechyd a diogelwch.

  • PM-139 Human Physiology I

    This module aims to provide an understanding of the structure and function of key physiological systems of the human body. Human physiology is the study of how our body works in an integrated way. A central principle of human physiology is homeostasis, the maintenance of a relatively stable internal environment. Failure to maintain homeostasis disrupts normal function that may lead to disease (or pathophysiology). Students will be taught the key concepts of homeostasis in the physiological systems of the body, enabling the student to understand the consequences of pathophysiology to human health. Students will gain practical experience in assessing respiration and cardiac function during two separate laboratory based exercises

  • PM-140 Anatomy and Embryology

    This module will provide knowledge of the structure of the human body, and how this adult anatomy develops during embryonic and foetal development. It will study human anatomy in a systems approach, focusing on the cardiovascular, gastrointestinal, musculoskeletal, urogenital, and nervous systems. Anatomy is a fundamental science and supports many areas of biology. As such the topics chosen for this module are those most useful to other areas of biological science, and are often clinically significant. This module will use practical classes to study human tissue and will develop the skills needed to dissect and study cadavers. Support materials and laboratory space for self directed learning will be available, including plastic anatomical models, bones and skeletons, and computer based anatomical models.

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.