Senior Lecturer
Swansea University Medical School
Telephone: (01792) 606409
Room: Academic Office - 427
Fourth Floor
Institute of Life Science 1
Singleton Campus

I am interested in the roles metabolism and the immune system play in disease progression. In particular, I focus on the aberrant cell signalling pathways that lead to chronic inflammatory diseases and resistance to chemotherapy in cancer. I obtained my BSc in Medical Microbiology from King’s College London and was awarded a PhD from Swansea University Medical School for investigating the role inflammation plays in throat cancer progression. I am a Senior Lecturer for our Genetics and Biochemistry Degree programmes and a Fellow of The Higher Education Academy. I teach Human Immunology, Medical Genetics (Module coordinator), Biomedical techniques (Module coordinator) and Cancer Immunotherapy to BSc and Masters students.

Areas of Expertise

  • Cancer
  • Immunology
  • Cell signalling
  • Metabolism

Publications

  1. & Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation. Frontiers in Immunology 8
  2. & Coordinated Role of Toll-Like Receptor-3 and Retinoic Acid-Inducible Gene-I in the Innate Response of Bovine Endometrial Cells to Virus. Frontiers in Immunology 8
  3. & Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology 9(5), 1125-1136.
  4. & Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. The FASEB Journal 29(4), 1516-1528.
  5. & Epithelial and Stromal Cells of Bovine Endometrium Have Roles in Innate Immunity and Initiate Inflammatory Responses to Bacterial Lipopeptides In Vitro via Toll-Like Receptors TLR2, TLR1, and TLR6. Endocrinology 155

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Teaching

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

    *

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-336 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

  • PMRM09 Dissertation (Research)

    This module builds on the knowledge and skills developed in teaching components in part one of their relevent programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.

  • PMZM15 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Supervision

  • Assessing the impact of micronuclei and the modes of action underlying these chromosomal aberrations (current)

    Student name:
    MSc
    Other supervisor: Dr George Johnson
  • Maternal Immunological Adaptation to Pregnancy (current)

    Student name:
    MSc
    Other supervisor: Prof Catherine Thornton
  • Steroid regulation of cellular resilience to cholesterol-dependent cytolysins (current)

    Student name:
    MSc
    Other supervisor: Prof Martin Sheldon
  • Induction of ferroptosis in chemotherapy-resistant ovarian cancer cells (current)

    Student name:
    MSc
    Other supervisor: Prof Martin Sheldon
  • Candidate gene vs genome-wide association study approaches in ASD: A systematic review to determine any overlapping genes (current)

    Student name:
    MRes
    Other supervisor: Dr Owen Bodger
  • The thesis was of a very high standard for this first year viva. (current)

    Student name:
    MPhil
    Other supervisor: Dr George Johnson
  • Role of Mitochondrial pyruvate carrier in ovarian cancer progression (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
    Other supervisor: Dr Deyarina Gonzalez
  • Multiplexed in vitro assay for genetic toxicology screening (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Rees
    Other supervisor: Dr George Johnson
  • N/a (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
  • The development and application of a MeDIP (methylated DNA immunoprecipitation) assay for epigenetic profiling of a 3D model of ovarian cancer cell lines and primary ascites-derived cells to determine a link between metabolism and drug-resistance in ovarian cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Lewis Francis

Administrative Responsibilities

  • Co-Director - Swansea University Medical School Postgraduate Research

    2017 - Present

  • Co-Chair - Swansea University Medical School Postgraduate Research Committee

    2017 - Present

  • Co-Director - Swansea University Medical School Postgraduate Admissions

    2017 - Present

  • Member - Athena SWAN Communications and Culture Working Group

    2017 - Present

Career History

Start Date End Date Position Held Location
2017 Present Senior Lecturer Swansea University Medical School
2014 2017 Lecturer Swansea University Medical School

Key Grants and Projects

  • Countering the unrestrained inflammation of sepsis by targeting the JAK-STAT pathway in human macrophages 2016 - 2017

    Research Project reference: NRNRGMar010 , with Professor Martin Sheldon (Swansea University), Dr Jenna Bowen (Cardiff University)

Research Groups

  • Sheldon/Cronin Research Group

    Sheldon/Cronin Research Group