I am interested in the role cell signalling molecules, and their receptors, play in disease. In particular, I focus on the aberrant cell signalling pathways that lead to chronic inflammatory diseases and resistance to chemotherapy in cancer. I obtained my BSc in Medical Microbiology from King’s College London and was awarded a PhD in chronic inflammation and cancer from Swansea University Medical School. I teach Human Immunology, Medical Genetics, and Cancer Immunotherapy to BSc and Master’s students.

Areas of Expertise

  • Immunology
  • Microbiology
  • Cell signalling
  • Reproduction
  • Cancer
  • Oncology
  • Inflammation
  • Endocrinology

Publications

  1. & Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunology 9(5), 1125-1136.
  2. & Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility. Reproductive Biology 16(1), 1-7.
  3. & Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium. PLOS ONE 11(3), e0151416
  4. Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility. Reproductive Biology
  5. & Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. The FASEB Journal 29(4), 1516-1528.

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Teaching

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-336 Research Skills

    This module is designed as a series of workshops for students to understand a range of molecular techniques, used by both Biochemists and Geneticists, that they are likely to encounter during their final year research project. Each workshop will cover the underlining theory relevant to a specific technique, practical hands-on experience of the technique in the lab, and a data analysis session. One workshop will run each week for 8 weeks. Students will be assessed by an in-class MCQ for some workshops or be required to prepare a 2,000-word report for a workshop that will be assessed and feedback provided.

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

  • PMZM15 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Supervision

  • Analysis of the In Vitro Micronucleus Data with Carcinogenicity Data using BMD-covariate analysis to develop robust risk analysis for a class of compounds (current)

    Student name:
    MSc
    Other supervisor: Dr George Johnson
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Martin Sheldon
    Other supervisor: Dr Deyarina Gonzalez
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Venkat Kanamarlapudi