Senior Lecturer
Swansea University Medical School
Telephone: (01792) 602742
Room: Academic Office - 427
Fourth Floor
Institute of Life Science 1
Singleton Campus

Martin gained his PhD at Edinburgh Napier University in 2009, in Nanoparticle In Vitro Toxicology, and spent the next 7.5 years in Switzerland conducting his post-doctoral research career before joining Swansea University Medical School in Dec 2015. 

Martin is motivated and enthusiastic, with core competence in particle and fibre toxicology. Martin’s research is focused on the nanoparticle-(mammalian)cell interaction, with a view to determining the mechanistic toxicological, immunological and genotoxic effects that nanoparticles, with varying physico-chemcial characteristics, may cause at the cellular level by using advanced, next-level in vitro systems combined with state-of-the-art microscopy and bioanalytical approaches. Special interests include the ability for nanoparticle geometry and surface properties to interfere with the human immune system and bloodstream. Another clear ambition of Martin's research is to create, study and promote alternative in vitro models that mimic in vivo environments to gain a mechanistic understanding of how nano-sized materials may, potentially, be adverse to human health. Special focus is also given to creating disease-based in vitro models and the role nanoparticles play in disease progression/exacerbation. 

In addition to his research interests, Martin is the Co-Director of Post-Graduate Research and Co-Chair of the SUMS Research Sub-Committee. Martin further supervises a number of PGR students at both the MSc and PhD level. Martin also actively contributes to teaching, on both the MSc Nanomedicine Taught Master's Programme as well the Genetics and Biochemistry Degree programmes.

Martin is Associate Edditor for the Journal of Nanobiotechnology, and an Editorial board member for Particle and Fibre Toxicology, Food and Chemical Toxicology, as well as Mutagenesis. Martin is the Deputy Chair and Secretary of the UK In Vitro Toxicology Society and is a panel member of the British Toxicology Society Sub-Committee. He is a Fellow of the European Respiratory Society (ERS Fellow), a Member of the Royal Society of Biology (MRSB), a Member of the UK Environmental Mutagenesis Society (UKEMS) and a panel member of the NC3Rs working group on Nanotoxicology. Martin has also been regularly contributing towards both National and International Conference organisation within the field of particle and fibre toxicology and in vitro systems.  

Areas of Expertise

  • Nanotoxicology
  • In Vitro Toxicology
  • Multi-cellular In Vitro Systems
  • Immunology
  • Nanoparticle-Cell Interactions
  • Microscopy
  • Air Pollution
  • Human Health Hazard Assessment
  • Lung
  • Air-Liquid Exposure Systems
  • Nanoscience
  • (Nano)Fibres

Publications

  1. & Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation. Archives of Toxicology
  2. et. al. Current characterization methods for cellulose nanomaterials. Chemical Society Reviews 47(8), 2609-2679.
  3. & (Pro-)fibrotic activity of multi-walled carbon nanotubes upon prolonged exposures in different human lung cell types. Applied In Vitro Toxicology
  4. & Respiratory hazard assessment of combined exposure to complete gasoline exhaust and respirable volcanic ash in a multicellular human lung model at the air-liquid interface. Environmental Pollution 238, 977-987.
  5. & Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?. Regulatory Toxicology and Pharmacology 91, 257-266.

See more...

Teaching

  • PM-120 Genetic Analysis I

    This module will give assignments designed to develop skills in essay writing and oral presentations. It will also look at the principles and practice of internet searching for scientific sources.

  • PM-304 Biomolecular Research Project

    *

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-351 Nanotoxicology

    Nanomaterials are comprised of particles that give many of the products we use increased strength, chemical reactivity or conductivity. They can also be the by-product of industrial processes or they can occur naturally, as with soot from forest fires or volcanic ash. The particles range in size from approximately 1 to 100 nanometres; that is 1 / 1,000,000,000th of a metre! Because they are so small, they are readily taken into our bodies through inhalation, ingestion or absorption through the skin. These particles have unique properties compared to their larger counterparts and we are only beginning to understand what their health effects may be.

  • PM-M28 Nano(geno)toxicology

    PM-M28 is a Taught Masters level module that focusses upon the field of Nanoparticle (geno)toxicology. The module is worth 20 credits. It occurs in the second semester, and is administered through both lecture-based and practical components. Students are taught by a variety of lecturers from academia, industry and clinical medicine. Students are assessed via both coursework (two (2) pieces) and examination. Briefly, Nano(geno)toxicology is a new, multi-interdisciplinary discipline that has evolved concomitantly with the development of the nanotechnology industry. The syllabus of this taught module encompasses general toxicology associated with nanomaterials (hazard and exposure assessments), their genetic toxicology implications, their physical and material properties as well as their applied formulations and scenarios. The module further provides insight into all these areas from the view of not only academia, but also industry and clinical medicine.

  • PMND00 Nanomedicine Research Dissertation

    This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study within nanomedicine.

  • PMNM10 Practical Approaches in Nanomedicine

    This module will be delivered over 1 academic week, with each day focussing on a different practical technique: Day 1: NP characterisation Day 2: (Advanced) Cell culture and NP exposure methods Day 3: NP-cell interaction (Mass spectrometry) Day 4: Biochemical techniques Day 5: Microscopy techniques Each day will begin with a 1hr-2hrs lecture on the practical, what they will do over the course of the day and theory behind the technique that they will be conducting. On each day students will gather data via the specified practical technique. At the end of the practical week, students will have produced sufficient data to allow them to produce an oral presentation and a critical evaluation of the findings.

  • PMRM09 Dissertation (Research)

    This module builds on the knowledge and skills developed in teaching components in part one of their relevent programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.

Supervision

  • Evaluating the long term effects of BOBATH for the management of children with cerebral palsy. (current)

    Student name:
    PhD
    Other supervisor: Dr Paul Rees
    Other supervisor: Dr Martin Clift
    Other supervisor: Dr Martin Clift
    Other supervisor: Dr Alice Hoon
  • Co-exposure of infectious bacteria with carbon-based nanoparticles in relevant, advanced in vitro systems. (current)

    Student name:
    MSc
    Other supervisor: Dr Martin Clift
    Other supervisor: Dr Thomas Wilkinson
  • Studying the mechanistic process associated with nanoparticle genotoxicity; focusing on NP impact on telomere length (current)

    Student name:
    MSc
    Other supervisor: Prof Shareen Doak
    Other supervisor: Dr Martin Clift
  • Deducing the mechanisms associated with the impact of Au and Ag ENPs upon telomere status in lung epithelial cells in vitro (current)

    Student name:
    MSc
    Other supervisor: Prof Shareen Doak
    Other supervisor: Dr Martin Clift
  • Mechanistic evaluation of the impact of superparamagnetic iron oxide nanoparticles conjugated with drugs (SPIONd) on intracellular signalling/homeostatic mechanisms (current)

    Student name:
    PhD
    Other supervisor: Dr Martin Clift
    Other supervisor: Prof Shareen Doak
  • In Vitro Lung Deposition-Models to Assess the Mechanistic Genotoxicity of Characterised Few-Layer Graphene (current)

    Student name:
    PhD
    Other supervisor: Dr Martin Clift
    Other supervisor: Prof Shareen Doak
  • Investigating the human health implications of e-cigarettes: An in vitro mechanistic toxicology approach. (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Dr Martin Clift
  • An advanced multi-cellular and dynamic flow model of the human alveolar airway to study the impact of inhaled particulate (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Dr Martin Clift
  • Understanding the human health impacts of graphene-based nanomaterials under occupational exposure scenarios (current)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
    Other supervisor: Dr Martin Clift
  • Correlating the Toxicity of Zinc Oxide Nanowires with Life Cycle Changes in Physical and Chemical Properties (current)

    Student name:
    PhD
    Other supervisor: Dr Martin Clift
    Other supervisor: Dr Thierry Maffeis
  • Mechanisms of Mammalian Egg Resilience, from the Macro to the Nano scale (current)

    Student name:
    PhD
    Other supervisor: Dr Martin Clift
    Other supervisor: Prof Martin Sheldon

Administrative Responsibilities

  • Co-Director Post-Graduate Research and Co-Chair SUMS Research Su

    2017 - Present

Career History

Start Date End Date Position Held Location
September 2008 September 2010 Post-Doctoral Researcher Institute of Anatomy, University of Bern, Bern, Switzerland
October 2010 October 2011 European Respiratory Society Long-Term Research Fellow Department of Clinical Research, University Hospital Bern, University of Bern, Bern, Switzerland
November 2011 November 2012 Senior Research Associate BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
November 2012 November 2015 Scientific Group Leader BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
December 2015 February 2017 Lecturer Swansea University Medical School, Swansea, Wales, UK
March 2017 Present Senior Lecturer Swansea University Medical School, Swansea, Wales, UK

Collaborative Partners

Partner Name Description
Unilever SEAC Collaboration via funded PhD studentship on advanced in vitro models

Academic History

Date Qualification Location
July 2004 BSc (Hons) Sport and Exercise Science Napier University, Edinburgh, Scotland, UK
July 2009 Doctor of Philosophy Edinburgh Napier University, Scotland, UK

External Responsibilities