Lecturer in Applied Medical Sciences and Medical Pharmacology
Swansea University Medical School
Telephone: (01792) 295056

Kate is a postdoctoral researcher in the In Vitro Toxicology and Cancer Group, based in the Institute of Life Science 1. Prior to completing her PhD in Genetic Toxicology at Swansea University (2010-2014), Kate read for a BSc in Biochemistry at the University of Bath (2007-2010). Kate has won several national and international awards during her research career to date, including the EEMS Young Scientist Travel Award, Welsh Livery Guild Travel Scholarship and Best New Investigator Platform Presentation at the USA EEMGS Meeting 2014.

Kate’s current research interests include in vitro carcinogenicity testing and novel genotypic and phenotypic markers in oesophageal cancer. Kate has also developed a keen interest in the reduction and replacement of laboratory animal use in genetic toxicology, exploring 3D tissue culture models, chronic exposures to chemicals and multiple-endpoint testing as robust alternatives. Kate lectures on several undergraduate and postgraduate degree courses.


  1. & A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 825, 51-58.
  2. & Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 819, 38-46.
  3. & A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology, 1-7.
  4. & Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology 13(1)
  5. & Acute Dosing and p53-Deficiency Promote Cellular Sensitivity to DNA Methylating Agents. Toxicological Sciences 144(2), 357-365.

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  • PM-138 Skills for Medical Sciences

    The aim of this module is to provide the student with basic skills required for laboratory research in the field of applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly applicable experimental techniques. They will also develop skills that are not experimental techniques themselves, but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing, ethics and health and safety.

  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

  • PM-336 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PM-342 Pharmacology

    Pharmacology is the science of how drugs act on the body and how the body acts on drugs. Pharmacology investigates the chemical and physical properties of drugs, how those properties confer actions on living tissues and how those actions affect health and disease. The beneficial, therapeutic effects of drugs will be discussed, but also some negative consequences of drug administration, such as toxicity, addiction and microbial drug-resistance.

  • PM-M28 Nano(geno)toxicology

    PM-M28 is a Taught Masters level module that focusses upon the field of Nanoparticle (geno)toxicology. The module is worth 20 credits. It occurs in the second semester, and is administered through both lecture-based and practical components. Students are taught by a variety of lecturers from academia, industry and clinical medicine. Students are assessed via both coursework (two (2) pieces) and examination. Briefly, Nano(geno)toxicology is a new, multi-interdisciplinary discipline that has evolved concomitantly with the development of the nanotechnology industry. The syllabus of this taught module encompasses general toxicology associated with nanomaterials (hazard and exposure assessments), their genetic toxicology implications, their physical and material properties as well as their applied formulations and scenarios. The module further provides insight into all these areas from the view of not only academia, but also industry and clinical medicine.

  • PMGM14 Molecular Pathology of Cancer and Application in Cancer Diagnosis, Screening, and Treatment

    This module covers the molecular mechanisms that underlie cancer development, growth and metastasis, and the differences between different cancers. It will explore the different molecular and cellular actions of anti-cancer treatments, the genomic factors affecting response and resistance to treatment, and the research approaches to anti-cancer drug design and development. Broad situations which confer a high cancer risk to a person and/or to other members of the same family will be discussed in the context of how genomic information may be integrated into cancer screening programmes. This module will prepare the students to interrogate the cancer data sets from the 100,000 Genomes Project

  • PMNM10 Practical Approaches in Nanomedicine

    This module will be delivered over 1 academic week, with each day focussing on a different practical technique: Day 1: NP characterisation Day 2: (Advanced) Cell culture and NP exposure methods Day 3: NP-cell interaction (Mass spectrometry) Day 4: Biochemical techniques Day 5: Microscopy techniques Each day will begin with a 1hr-2hrs lecture on the practical, what they will do over the course of the day and theory behind the technique that they will be conducting. On each day students will gather data via the specified practical technique. At the end of the practical week, students will have produced sufficient data to allow them to produce an oral presentation and a critical evaluation of the findings.