I am a research officer in the research team of Dr Spyridon Theofilopoulos.

I hold a BSc in Genetics and a Health and Care Research Wales funded PhD in Medical and Health Care Studies both from Swansea University. My PhD focused on the function of innate immune receptors in gestation associated tissues. This has led to a long-standing interest on the role innate immunity in health and disease, particularly relating to the inflammasome and IL-1 family cytokines.

My current research involves identifying the function and mechanism of action of cholesterol metabolites, up- or down-regulated in Parkinson’s disease (PD) patients. Any newly identified neuroprotective agents will be examined to determine if they can prevent or rescue phenotypic features of PD in models of PD.

Further to my research role, I also contribute to teaching at different levels across the medical school.

Areas of Expertise

  • Innate Immunity
  • Inflammation
  • Placental Inflammation & Immunology

Publications

  1. & Expression and function of NOD-like receptors by human term gestation-associated tissues. Placenta 58, 25-32.
  2. & Production and regulation of interleukin-1 family cytokines at the materno-fetal interface. Cytokine 99, 194-202.
  3. & Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors. Clinical & Experimental Immunology
  4. & Interleukin 4 and interleukin 13 downregulate the lipopolysaccharide-mediated inflammatory response by human gestation-associated tissues†. Biology of Reproduction 96(3), 576-586.
  5. & Functional activity but not gene expression of toll-like receptors is decreased in the preterm versus term human placenta. Placenta

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Teaching

  • PM-132 Eukaryotic Cell Biology

    This module will provide a broad introduction to fundamental concepts in Eukaryotic cell biology investigating the origins of the cell, cell structure and specialised cells and cells in disease. There will be a general focus on human cells throughout with reference to other organisms when needed. Students will gain practical experience in identification, differentiation of cells from different human and animal species.

  • PM-132C Bioleg Celloedd Ewcaryotig

    Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.