Areas of Expertise

  • Plastic Reconstructive and Burn Surgery
  • Nanomedicine (polymer therapeutics)
  • Drug Discovery
  • Translational research

Publications

  1. Polyaniline-graphene based α-amylase biosensor with a linear dynamic range in excess of 6 orders of magnitude. Biosensors and Bioelectronics 85, 395-402.
  2. & Chromophores in operative surgery: Current practice and rationalized development. Journal of Controlled Release 249, 123-130.
  3. & Clinical applications of amylase: Novel perspectives. Surgery
  4. & Development and Validation of an In Vitro Pharmacokinetic/Pharmacodynamic Model to Test the Antibacterial Efficacy of Antibiotic Polymer Conjugates. Antimicrobial Agents and Chemotherapy 59(4), 1837-1843.
  5. (in press). Royal College of Surgeons in England 2015 Hunterian Professor.

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Teaching

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Supervision

  • Graphene-based amylase biosensor for infection diagnosis (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • A novel biomarker for infection (awarded 2016)

    Student name:
    MSc
    Other supervisor: Prof Steve Conlan
    Other supervisor: Prof Iain Whitaker