Dr Colin Restall
Associate Professor
Swansea University Medical School
Telephone: (01792) 295571

Dr Colin Restall is an Associate Professor on our Biochemistry Degrees

Areas of Expertise

  • Biochemistry and Biophysics of Biological Membranes
  • Optical Spectroscopy

Publications

  1. & Negatively-Marked MCQ Assessments That Reward Partial Knowledge Do Not Introduce Gender Bias Yet Increase Student Performance and Satisfaction and Reduce Anxiety.. PLoS ONE 8(2)
  2. & Steroid hormone-induced effects on membrane fluidity and their potential roles in non-genomic mechanisms.. Life Sciences 67, 743-757.
  3. & Developmental and neurochemical effects of early postnatal exposure to flumazenil in female and male mice.. Psicothema 12, 648-653.
  4. & Changes in the neural membranes of mice related to steroid hormone influences.. Pharmacology, Biochemistry and Behaviour. 59, 829-833.
  5. & Characterisation of the binding of leukotriene B-4 to macrophages of the rainbow trout Oncorhynchus mykiss.. J. Exp. Biol. 200, 155-160.

See more...

Teaching

  • PM-120 Genetic Analysis I

    This module will give assignments designed to develop skills in essay writing and oral presentations. It will also look at the principles and practice of internet searching for scientific sources.

  • PM-127 Energy and Metabolism: The Reactions of Life

    This module begins with an introduction to enzymology, enzyme kinetics and enzyme regulation. Next there is an introduction to bioenergetics and a discussion of the central metabolic pathways by which energy from food is used to fuel the synthesis of the energy currency molecule ATP (with particular attention to glycolysis, the citric acid cycle, ß oxidation of fatty acids, and oxidative phosphorylation). The concept of tissue and organ specificity is introduced, and finally the role of the hormones insulin, glucagon, epinephrine, growth hormone, thyroid hormone and leptin in controlling these pathways and producing effects on the body is considered.

  • PM-130 Biochemistry Skills Development

    This module is designed to develop the skills required for students of biochemistry and medical biochemistry. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint session cover generic skills such as internet searching for scientific sources, referencing and plagiarism

  • PM-131 Chemistry of Life

    The module provides a broad study of the interactions between chemical processes and biological systems. It addresses the chemical processes used by organisms to utilize chemicals for energy production, structural functions and as building blocks of macromolecules.

  • PM-243 Clinical Biochemistry & Physiology

    The module begins with a discussion of selected metabolic disorders of carbohydrate metabolism and their pathological consequences with particular emphasis on diabetes mellitus. The molecular mechanisms underlying polycystic ovarian syndrome are then considered. This is followed by a consideration of the biochemical basis of haemostasis and blood clot lysis. Next there is a discussion of inborn errors of metabolism, and the biochemical pathways affected. Finally the module reviews mechanisms of protein transport and their relevance to storage diseases.

  • PM-245 Metabolic Regulation: Enzymes & Signal Transduction

    This module reviews the basic elements of enzyme kinetics, including their mechanism and inhibition. The control of enzyme function by allosteric mechanisms is considered together with an appreciation of the significance of sigmoid kinetics. An overview of coenzymes and (metal) co-factors in enzyme function is given together with a description of the role played by vitamins in co-enzyme production. The module concludes with an overview of enzymes from extremophiles and their applications.

  • PM-248 Amino acids, lipids and steroids

    The module reviews the pathways of fatty acid degradation (beta-oxidation) before describing the biochemistry of the multi-functional proteins that catalyse the formation of fatty acids. The mechanisms of fatty acid elongation and desaturation are covered along with the synthesis of triacylglycerols and glycerophospholipids with consideration being being given to the control of these pathways. The synthesis of cholesterol via the mevalonate pathway is described along with the various metabolic control points and an understanding of dietary lipid transport. The further metabolism of cholesterol to bile salts, steroid hormones and vitamin D is outlined with consideration given to the stereochemistry of these compounds. The module provides a sound basis for understanding the metabolism of amino acids, lipids and steroids. The pathways of amino acid synthesis and degradation in humans are described along with an introduction to the urea cycle.

  • PM-253 Techniques in Molecular Biology

    The module will provide a sound theoretical and practical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.

  • PM-253C Technegau Bioleg Foleciwlaidd

    Bydd y modiwl yn darparu sylfaen ddamcaniaethol ac ymarferol gref ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoir pwyslais penodol ar dechnoleg ailgyfuno DNA, dilyniannu cenhedlaeth nesaf, transgriptomeg, proteomeg a sbectrometreg màs.

  • PM-257 Neuroscience

    In order to help students understand the biological basis for behavioural neuroscience and neurological disorders, this module seeks to integrate the multidisciplinary sciences ¿ for example, anatomy, physiology and biochemistry - that have combined to build the emerging field of neuroscience. The aim is to gain a mechanistic and holistic knowledge of the nervous system that builds from the molecular, cellular and developmental, to the systems level. In addition to exploring normal function, this module will introduce common disorders of the central and peripheral nervous systems in an integrated way. Students will be guided in exploring the scientific evidence around what is known and unknown and will be introduced to current research findings in the scientific literature.

  • PM-319 Membranes and Energy Transduction

    The module provides an understanding of the dynamic structure and properties of biological membranes and the nature of lipid-lipid and lipid-protein interactions. An appreciation of the molecular architecture of energy-conserving membranes is also provided together with an understanding of the molecular mechanisms involved in energy transduction.

  • PM-333 Aspects of Human Sensory and Metabolic Biochemistry

    This module introduces students to the physiology and biochemistry of the Central Nervous System (CNS). Special aspects of central nervous system biochemistry such as the provision of energy for the brain, the metabolism of neurotransmitters and the role of neurotransmitters in controlling behaviour is also considered. Consideration is given to defects in the CNS and the implications for pathological states such as epilepsy, Parkinson's Disease and Multiple sclerosis. The module concludes with a description of the biochemistry and physiology of visual transduction, olfaction and sensory biochemistry.

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

Administrative Responsibilities

  • Associate Dean of Undergraduate Studies - Medicine

    2011 - Present