I gained my PhD in 2006 specialising in mitochondrial genetics of cancer, however since then has worked in the field of diabetes research. I joined the Diabetes Research Group in 2007, where my research has focused on investigating the links between Type 2 diabetes and obesity, and their associated comorbidities. The Diabetes Group now has its own unit based in the Grove Building and our research sits with the College “Biomarkers and Genes” Theme. I focus on Type 2 diabetes associated-obesity and the identification of molecular biomarkers for the association with specific cardiovascular comorbidities as well as having interests in bariatric surgery and weight loss. Aside from Type 2 diabetes research, I also collaborate in the field of retinopathy and the mechanisms behind its progression. I am a Senior Lecturer in Diabetes and teach on the Genetics and Medical Genetics BSc degree schemes in the Medical School, as well as contributing to Sports Science BSc degree (College of Engineering) and several modules on the Graduate Entry Medical Degree scheme. 

Areas of Expertise

  • Diabetes
  • Oxidative stress
  • Obesity
  • biomarker
  • Gene variant

Publications

  1. & Temporal Effect of Bariatric Surgery on Predicted 10-Year and Lifetime Cardiovascular Risk at 1 Month, 6 Months, and 5 Years Following Surgery: A Pilot Study. Metabolic Syndrome and Related Disorders 15(3), 130-136.
  2. & Bariatric Surgery Is Accompanied by Changes in Extracellular Vesicle-Associated and Plasma Fatty Acid Binding Protein 4. Obesity Surgery
  3. & Gene-Environment Interaction and Oxidative Stress in Cardiovascular Disease. In Philip Peplow, James Adams, Tim Young (Ed.), Cardiovascular and Metabolic Disease - Scientific Discoveries and New Therapies. (pp. 160-185). Cambridge: Royal Society of Chemistry.
  4. & Temporal changes in plasma markers of oxidative stress following laparoscopic sleeve gastrectomy in subjects with impaired glucose regulation. Surgery for Obesity and Related Diseases
  5. & The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina. Journal of Diabetes & Metabolism 7(7)

See more...

Teaching

  • PM-133 Evolutionary and Molecular Genetics

    The module starts with a consideration of aspects of genetics and related topics, eg. mitosis and meiosis, mutation, genomes, recombination, transcription, translation, protein structure and protein properties. The second part of the module deals with evolutionary biology, natural selection and variation, molecular evolution, species and their creation, classification and phylogeny.

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

    *

  • PM-315 Genetic Analysis III

    The module aims to develop the student¿s ability to critically analyse and synthesise advanced research topics in genetics and molecular biology, and their oral and written scientific presentation skills.

Supervision

  • The anti-inflammatory effects of dairy colostrum Neovite as a dietary supplement for humans (current)

    Student name:
    MSc
    Other supervisor: Dr Richard Bracken
  • Ghrelin mediated lipid retention and insulin resistance in human visceral adipose tissue (current)

    Student name:
    PhD
    Other supervisor: Dr Jeffrey Davies
    Other supervisor: Prof Jeffrey Stephens