Publications

Journal Articles

  1. & Dose–response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay. Archives of Toxicology
  2. & Development of an in vitro PIG-A gene mutation assay in human cells. Mutagenesis 32(2), 283-297.
  3. & Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay. Environmental and Molecular Mutagenesis
  4. & Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations. Environmental and Molecular Mutagenesis
  5. & Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells. Archives of Toxicology
  6. & Genotoxicity of flubendazole and its metabolitesin vitroand the impact of a new formulation onin vivoaneugenicity. Mutagenesis 31(3), 309-321.
  7. & Estimating the carcinogenic potency of chemicals from thein vivomicronucleus test. Mutagenesis 31(3), 347-358.
  8. & Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations. Mutagenesis 31(3), 255-263.
  9. & Empirical analysis of BMD metrics in genetic toxicology part II:in vivopotency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment. Mutagenesis 31(3), 265-275.
  10. & Genetic Toxicology at the Crossroads – From Qualitative Hazard Evaluation to Quantitative Risk Assessment. Mutagenesis 31
  11. & A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 808, 8-19.
  12. & Genetic toxicology at the crossroads—from qualitative hazard evaluation to quantitative risk assessment. Mutagenesis 31(3), 233-237.
  13. & Measuring Reproducibility of Dose Response Data for the Pig-a Assay using Covariate Benchmark Dose Analysis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  14. & Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research/Reviews in Mutation Research
  15. & A Review: The Current In Vivo Models for the Discovery and Utility of New Anti-leishmanial Drugs Targeting Cutaneous Leishmaniasis. PLOS Neglected Tropical Diseases 9(9), e0003889
  16. & The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency. Mutagenesis, gev069
  17. & Correlation of in vivo versus in vitro benchmark doses (BMDs) derived from micronucleus test data: A proof of concept study. Toxicological Sciences 148(2), 355-367.
  18. & MutAIT: an online genetic toxicology data portal and analysis tools. Mutagenesis, gev050
  19. & Theoretical considerations for thresholds in chemical carcinogenesis. Mutation Research/Reviews in Mutation Research 765, 56-67.
  20. & IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs). Mutation Research/Genetic Toxicology and Environmental Mutagenesis 783, 55-65.
  21. & IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 783, 66-78.
  22. & New Approaches to Advance the use of Genetic Toxicology Analyses for Human Health Risk Assessment and Regulatory Decision-Making. Toxicol. Res.
  23. & Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environmental and Molecular Mutagenesis 55(8), 609-623.
  24. & Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice. Environmental and Molecular Mutagenesis, n/a-n/a.
  25. & Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis 29(3), 155-164.
  26. & Influence of DNA Repair on Nonlinear Dose-Responses for Mutation. Toxicological Sciences 132(1), 87-95.
  27. & Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environmental and Molecular Mutagenesis 54(1), n/a-18.
  28. & A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens. PLoS ONE 8(5), e64532
  29. & Diagnostic correlation between the expression of the DNA repair enzymeN-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study. Diseases of the Esophagus 26(6), 644-650.
  30. & Investigating Mechanisms for Non-linear Genotoxic Responses, and Analysing Their Effects in Binary Combination. Genes and Environment 34(4), 179-185.
  31. & Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance. Toxicological Sciences 128(2), 387-397.
  32. & N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate-Induced Chromosome Damage. Toxicological Sciences 119(2), 346-358.
  33. & Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 702(2), 189-192.
  34. & Genotoxic thresholds, DNA repair, and susceptibility in human populations. Toxicology 278(3), 305-310.
  35. & Dose-Response Relationships for N7-(2-Hydroxyethyl)Guanine Induced by Low-Dose [14C]Ethylene Oxide: Evidence for a Novel Mechanism of Endogenous Adduct Formation. Cancer Research 69(7), 3052-3059.
  36. et. al. Non-linear dose–response of DNA-reactive genotoxins: Recommendations for data analysis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 678(2), 95-100.
  37. & Mechanistic investigations of low dose exposures to the genotoxic compounds bisphenol-A and rotenone. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 651(1-2), 56-63.
  38. & No-observed effect levels are associated with up-regulation of MGMT following MMS exposure. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 648(1-2), 9-14.
  39. & Mechanistic Influences for Mutation Induction Curves after Exposure to DNA-Reactive Carcinogens. Cancer Research 67(8), 3904-3911.
  40. & Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene 25(56), 7336-7342.
  41. Do dose response thresholds exist for genotoxic alkylating agents?. Mutagenesis 20(6), 389-398.
  42. & The detection of genotoxic activity and the quantitative and qualitative assessment of the consequences of exposures. Experimental and Toxicologic Pathology 57, 205-212.
  43. Detection and characterization of mechanisms of action of aneugenic chemicals. Mutagenesis 17(6), 509-521.

Book Chapters

  1. & The Applicable Use of the HPRT Gene Mutation Assay as a Practical Tool in Mutagenesis and DNA Repair Studies. In Sierra, L. María, Gaivão, Isabel (Ed.), Genotoxicity and DNA Repair. -197). Springer.
  2. Genotoxic Thresholds. In Andrew Teasdale (Ed.), Genotoxic Impurities Strategies for Identification and Control. (pp. 444