I am an academic gastroenterologist and translational cancer researcher with a focus on prevention. My research background is in genetic toxicology, having worked in the area of DNA damage and mechanisms of carcinogenesis. My current focus is on the preclinical and early clinical development of therapies to prevent cancer and the discovery, development and validation of accompanying molecular biomarkers for monitoring the efficacy of interventions and individualising therapy.

Areas of Expertise

  • Gastroenterology
  • Digestive Oncology
  • Gastro-Oesophageal Reflux Disease
  • Barrett's Oesophagus
  • Oesophageal Adenocarcinoma
  • Biomarkers

Publications

  1. & The jury is still out on the safety of silver nanoparticles. BMJ 346(jan15 4), f227-f227.
  2. & Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells.. Carcinogenesis 33(11), 2035-2043.
  3. & The management of diabetes in terminal illness related to cancer. QJM 105(1), 3-9.
  4. & Peritoneal mesothelioma. British Journal of Hospital Medicine 71(5), 290-291.
  5. & Apoplexy in a corticotrophin-secreting pituitary macroadenoma: a case report and review of the literature. QJM 103(8), 607-609.

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Teaching

  • PM-139 Human Physiology I

    This module aims to provide an understanding of the structure and function of key physiological systems of the human body. Human physiology is the study of how our body works in an integrated way. A central principle of human physiology is homeostasis, the maintenance of a relatively stable internal environment. Failure to maintain homeostasis disrupts normal function that may lead to disease (or pathophysiology). Students will be taught the key concepts of homeostasis in the physiological systems of the body, enabling the student to understand the consequences of pathophysiology to human health. Students will gain practical experience in assessing respiration and cardiac function during two separate laboratory based exercises

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.

  • PM-317 Genetics of Cancer

    This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.