Dr Deyarina Gonzalez
Associate Professor
Swansea University Medical School
Telephone: (01792) 295384

Deya’s research focuses on gene expression and function in the uterus and its relationship to fertility and cancer. Her clinical interests are Polycystic Ovary Syndrome (PCOS), endometriosis, unexplained infertility and gynaecological cancers (endometrial, ovarian and cervical cancer). She has strategic collaborations with clinicians at Abertawe Bro Morgannwg University NHS health board, developing cellular and molecular approaches to determine mechanisms underlying gynaecological pathologies, to identify biomarkers. Her projects on endometrial implantation and differentiation, relate to L-selectin ligands (MUC1), hormone nuclear receptors and WT1 pathway. Her research in gynaecological cancer includes the regulation of tamoxifen target genes in endometrium and new methods to identify biomarkers for pre-disposition of infertile women to develop gynaecological cancers. She leads an international research network (Prof. Rojas, Catholic University of Maule and Dr. Gracia, Director of Maule Clinic, Chile), studying protein glycation in relation to altered endometrial function.
Her aim is to translate basic research into clinically relevant observations for patient benefit. Her projects involve collaboration with the private sector to expedite validation of clinical diagnostic biomarkers and the development of new drug leads for targeted cancer therapy. She also has multidisciplinary collaborations in the area of nanosensors and improved performance medications in the field of human reproductive biology and hormone therapy. She has received research grant valuing over £1m in the recent years.
Deya has published more than 20 articles during her career on human, animal, plant and yeast research. She is a member of the Endocrine Society and acts as an expert reviewer for Journal of Clinical Endocrinology and Metabolism, Human Reproduction and others. She teaches within the Genetics & Biochemistry (College of Medicine) and Biomedical Engineering (College of Engineering) undergraduate programmes.

Publications

  1. & Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences 111(7), 2500-2505.
  2. & Epitaxial graphene immunosensor for human chorionic gonadotropin. Sensors and Actuators B: Chemical 190, 723-729.
  3. & iNOS Activation Regulates β-catenin Association with Its Partners in Endothelial Cells. PLoS ONE 7(12), e52964
  4. et. al. MAGE-11 profiling in fertile, infertile PCOS and endometriosis human endometrium. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 120, 205-205.
  5. & The effect of the Wilms tumour suppressor protein (WT1) on regulating cellular morphology and gene expression in endometrial stromal cells. EUROPEAN JOURNAL OF CANCER 49, S135-S136.

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Teaching

  • PM-120 Genetic Analysis I

    This module will give assignments designed to develop skills in essay writing and oral presentations. It will also look at the principles and practice of internet searching for scientific sources.

  • PM-132 Eukaryotic Cell Biology

    This module will provide a broad introduction to fundamental concepts in Eukaryotic cell biology investigating the origins of the cell, cell structure and specialised cells and cells in disease. There will be a general focus on human cells throughout with reference to other organisms when needed. Students will gain practical experience in identification, differentiation of cells from different human and animal species.

  • PM-132C Bioleg Celloedd Ewcaryotig

    Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

  • PM-200 Genetic Analysis II

    This module will give assignments designed to build on essay writing and oral presentation skills introduced in level 1. It will also develop critical evaluation, analysis skills for the understanding of peer-reviewed research papers.

  • PM-243 Clinical Biochemistry & Physiology

    The module begins with a discussion of selected metabolic disorders of carbohydrate metabolism and their pathological consequences with particular emphasis on diabetes mellitus. The molecular mechanisms underlying polycystic ovarian syndrome are then considered. This is followed by a consideration of the biochemical basis of haemostasis and blood clot lysis. Next there is a discussion of inborn errors of metabolism, and the biochemical pathways affected. Finally the module reviews mechanisms of protein transport and their relevance to storage diseases.

  • PM-304 Biomolecular Research Project

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  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PMNM02 Diagnostics and Imaging

    Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

  • PMNM07 Diagnostics and Imaging

    Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

  • PMZM13 Diagnostics and Imaging

    Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

Supervision

  • Development of innovative technologies in women health for the clinical diagnosis of female infertility and gynaecological cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • Development of novel Antibody Drug Conjugates for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • Antibody-drug conjugates for gynaecological cancers. (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • Identification of biomarkers associated with the development of ovarian cancer in at risk patients diagnosed with ovarian endometriosis (current)

    Student name:
    MSc
    Other supervisor: Prof Steve Conlan
  • Silicon nanowire biosensors for multiplexed hormone and Lithium detection (current)

    Student name:
    PhD
    Other supervisor: Prof Owen Guy
  • Integrating image-based machine learning and in-line biochemical analysis for enhancing successful IVF/ICSI Outcome (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • Targeted therapies for oncology applications (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • Role of mitochondrial pyruvate carrier in ovarian cancer progression (current)

    Student name:
    PhD
    Other supervisor: Dr James Cronin
    Other supervisor: Prof Martin Sheldon
  • 'Role of chronic urinary infection in the pathophysiology of overactive bladder syndrome' (current)

    Student name:
    MD
    Other supervisor: Prof Steve Conlan