Areas of Expertise

  • Innate Immunity - neutrophils and complement system
  • Bioenergetics

Publications

  1. & Bioenergetic analysis of human peripheral blood mononuclear cells. Clinical & Experimental Immunology 182(1), 69-80.
  2. & A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome. Blood 119(2), 591-601.
  3. & Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813(10), 1822-1826.
  4. & Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proceedings of the National Academy of Sciences 108(21), 8761-8766.
  5. & Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid. Rheumatology 48(1), 39-44.

Teaching

  • PM-127 Energy and Metabolism: The Reactions of Life

    This module begins with an introduction to enzymology, enzyme kinetics and enzyme regulation. Next there is an introduction to bioenergetics and a discussion of the central metabolic pathways by which energy from food is used to fuel the synthesis of the energy currency molecule ATP (with particular attention to glycolysis, the citric acid cycle, ß oxidation of fatty acids, and oxidative phosphorylation). The concept of tissue and organ specificity is introduced, and finally the role of the hormones insulin, glucagon, epinephrine, growth hormone, thyroid hormone and leptin in controlling these pathways and producing effects on the body is considered.

  • PM-130 Biochemistry Skills Development

    This module is designed to develop the skills required for students of biochemistry and medical biochemistry. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint session cover generic skills such as internet searching for scientific sources, referencing and plagiarism

  • PM-131 Chemistry of Life

    The module provides a broad study of the interactions between chemical processes and biological systems. It addresses the chemical processes used by organisms to utilize chemicals for energy production, structural functions and as building blocks of macromolecules.

  • PM-132 Eukaryotic Cell Biology

    This module will provide a broad introduction to fundamental concepts in Eukaryotic cell biology investigating the origins of the cell, cell structure and specialised cells and cells in disease. There will be a general focus on human cells throughout with reference to other organisms when needed. Students will gain practical experience in identification, differentiation of cells from different human and animal species.

  • PM-132C Bioleg Celloedd Ewcaryotig

    Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

  • PM-133 Evolutionary and Molecular Genetics

    The module starts with a consideration of aspects of genetics and related topics, eg. mitosis and meiosis, mutation, genomes, recombination, transcription, translation, protein structure and protein properties. The second part of the module deals with evolutionary biology, natural selection and variation, molecular evolution, species and their creation, classification and phylogeny.

  • PM-243 Clinical Biochemistry & Physiology

    The module begins with a discussion of selected metabolic disorders of carbohydrate metabolism and their pathological consequences with particular emphasis on diabetes mellitus. The molecular mechanisms underlying polycystic ovarian syndrome are then considered. This is followed by a consideration of the biochemical basis of haemostasis and blood clot lysis. Next there is a discussion of inborn errors of metabolism, and the biochemical pathways affected. Finally the module reviews mechanisms of protein transport and their relevance to storage diseases.

  • PM-246 Biochemistry Skills Development II

    This module is designed to develop the skills required for students of biochemistry. Students meet with tutors and will be given a series of assignments designed to develop skills in key areas including essay writing, presentation and analysis of research papers.

  • PM-246C Datblygu Sgiliau Biocemeg II

    Nod y modiwl hwn yw datblygu'r sgiliau mae eu hangen ar fyfyrwyr biocemeg. Bydd myfyrwyr yn cwrdd â thiwtoriaid ac yn derbyn cyfres o aseiniadau at ddiben datblygu eu sgiliau mewn meysydd allweddol, gan gynnwys ysgrifennu traethodau, cyflwyno a dadansoddi papurau ymchwil.

  • PM-249 Human Immunology

    The course is designed as an introduction to immunology and the human immune system. The course covers the fundamentals of immunology including functional perturbations associated with disease and experimental approaches to the study of immunology.

  • PM-253 Techniques in Molecular Biology

    The module will provide a sound theoretical and practical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.

  • PM-253C Technegau Bioleg Foleciwlaidd

    Bydd y modiwl yn darparu sylfaen ddamcaniaethol ac ymarferol gref ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoir pwyslais penodol ar dechnoleg ailgyfuno DNA, dilyniannu cenhedlaeth nesaf, transgriptomeg, proteomeg a sbectrometreg màs.

  • PM-304 Biomolecular Research Project

    *

  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

Supervision

  • 'The Development and Optimisation of Analytical Techniques to Analyse Ceramide in an Attempt to Determine its Potential Physiological Role in Apoptotic Processes.' (current)

    Student name:
    MSc
    Other supervisor: Dr Ed Dudley