Dr Lewis Francis
Senior Lecturer
Swansea University Medical School
Telephone: (01792) 602716
Room: Office CNH - 016
Ground Floor
Institute of Life Science 2
Singleton Campus

Publications

  1. & Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology, Biology and Medicine
  2. & Characterization of pulp derived nanocellulose hydrogels using AVAP® technology. Carbohydrate Polymers 198, 270-280.
  3. & Ultrasensitive environmental assessment of xeno-estrogens in water samples using label-free graphene immunosensors. Analytical Biochemistry 548, 102-108.
  4. & Specific and highly efficient condensation of GC and IC DNA by polyaza pyridinophane derivatives. International Journal of Biological Macromolecules
  5. & Organic matter identifies the nano-mechanical properties of native soil aggregates. Nanoscale 10(2), 520-525.

See more...

Teaching

  • PM-120 Genetic Analysis I

    This module is designed to develop the skills required for students of genetics and medical genetics. Students will meet with tutors and be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy. Joint sessions will cover generic skills such as internet searching for scientific sources, referencing and plagiarism.

  • PM-240 Carbohydrate Metabolism and Glycobiology

    Saccharides are the major source of energy and carbon that is used by the cell for growth and maintenance. The central roles of glycolysis in providing cellular energy and components from saccharides substrates, and the regulation of these processes are explained. The relationship between glycolysis and glycogen metabolism in mammals is explored as one of the ways in which substrate supply to the pathway is regulated. The complexity of the mechanisms, including hormonal, for controlling glycolysis and gluconeogenesis in mammalian to maintain blood concentrations is compared to glycogen and glucose metabolism in muscle tissue. The role or glycosyltransferases in the synthesis of oligo- and polysaccharides, including glycoprotein assembly, is also explained.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

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  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-357 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PMND00 Nanomedicine Research Dissertation

    This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study within nanomedicine.

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

  • PMZM15 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Supervision

  • Develop/utilise Nano-encapsulation technology for transdermal drug delivery (current)

    Student name:
    PhD
    Other supervisor: Dr Zhidao Xia
  • Utilising Marine Collagen as a Niche Structure for Enhanced Osteoarthritic Repair (current)

    Student name:
    PhD
    Other supervisor: Dr Ilyas Khan
  • Characterisation of tracheal-derived chondroprogenitor cells. (current)

    Student name:
    PhD
    Other supervisor: Dr Ilyas Khan
  • The development and application of a MeDIP (methylated DNA immunoprecipitation) assay for epigenetic profiling of a 3D model of ovarian cancer cell lines and primary ascites-derived cells to determine a link between metabolism and drug-resistance in ovarian cancer (current)

    Student name:
    PhD
    Other supervisor: Dr James Cronin
  • Chondroprogenitor cells as source for cartilage repair using a biomimetic 3D repair model in vitro.«br /»«br /»«br /» (current)

    Student name:
    PhD
    Other supervisor: Dr Ilyas Khan
  • Geochemistry of cancer: Effect of Selenium as a treatment and characterization of a copper biomarker of ovarian cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • 3D-patient derived tumour model for epigenetic drug testing«br /»«br /» initiate experiments using ovarian cancer cells isolated from ascitic fluid «br /»«br /» continue the assessment of collagen scaffolds (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • '''Atomic force microscopy study of the interactions between colloids and surfaces- membranes and cells''' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Dr Yon Ju-Nam
    Other supervisor: Dr Christopher Wright
  • 'Aberrant Epigenetics and the Differentiation of Gynaecological Cancers' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • 'The impact of HBO1 in Ovarian Cancer' (awarded 2018)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan

Research Groups