Dr Lewis Francis
Senior Lecturer
Swansea University Medical School
Telephone: (01792) 602716

Publications

  1. & Progesterone induces nano-scale molecular modifications on endometrial epithelial cell surfaces. Biology of the Cell 101(8), 481-493.
  2. & Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner. Psychoneuroendocrinology 63, 198-207.
  3. & Chondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving Chondrogenesis. Stem Cells Translational Medicine 5(5), 670-682.
  4. Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget
  5. & Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proceedings of the National Academy of Sciences 111(7), 2500-2505.

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Teaching

  • PM-120 Genetic Analysis I

    This module will give assignments designed to develop skills in essay writing and oral presentations. It will also look at the principles and practice of internet searching for scientific sources.

  • PM-240 Carbohydrate Metabolism and Glycobiology

    Saccharides are the major source of energy and carbon that is used by the cell for growth and maintenance. The central roles of glycolysis in providing cellular energy and components from saccharides substrates, and the regulation of these processes are explained. The relationship between glycolysis and glycogen metabolism in mammals is explored as one of the ways in which substrate supply to the pathway is regulated. The complexity of the mechanisms, including hormonal, for controlling glycolysis and gluconeogenesis in mammalian to maintain blood concentrations is compared to glycogen and glucose metabolism in muscle tissue. The role or glycosyltransferases in the synthesis of oligo- and polysaccharides, including glycoprotein assembly, is also explained.

  • PM-300 Medical Genetics

    The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.

  • PM-304 Biomolecular Research Project

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  • PM-334 Biochemistry Literature Review and Communication

    Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.

  • PM-336 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PMND00 Nanomedicine Research Dissertation

    This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study within nanomedicine.

  • PMNM04 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

  • PMZM15 Nanomedicines and Therapeutics

    The module will explore the history and development of molecular medicines. Using landmark technology and chemical development phases, the traditional small chemical entities using in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. The common target oncology and non oncology disorders will outlined and their respective targets for such medicines detailed alongside drug modes of action and delivery (IV and oral). Further exploration of targeted nanoparticle delivery, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems, will expand the knowledge to future molecular medicines such as antibody drug conjugates and kinase inhibitors. Excitingly the module will include guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Supervision

  • Cell surface characterisation of articular cartilage-derived chondroprogenitors using flow cytometry (current)

    Student name:
    PhD
    Other supervisor: Dr Ilyas Khan
  • 'Aberrant Epigenetics and the Differentiation of Gynaecological Cancers' (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • '''Atomic force microscopy study of the interactions between colloids and surfaces- membranes and cells''' (current)

    Student name:
    PhD
    Other supervisor: Dr Christopher Wright
    Other supervisor: Dr Yon Ju-Nam
  • Utilising Marine Collagen as a Niche Structure for Enhanced Osteoarthritic Repair (current)

    Student name:
    PhD
    Other supervisor: Dr Ilyas Khan
  • Develop/utilise Nano-encapsulation technology for transdermal drug delivery (current)

    Student name:
    PhD
    Other supervisor: Dr Zhidao Xia
  • The impact of HBO1 in Ovarian Cancer (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • Characterization and application of articular chondroprogenitor cells (current)

    Student name:
    PhD
    Other supervisor: Dr Ilyas Khan
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan