Areas of Expertise

  • nanoparticles
  • Streptomyces
  • molecular biology
  • insect symbionts
  • genomics

Publications

  1. A tale of tails: deciphering the contribution of terminal tails to the biochemical properties of two Dps proteins from Streptomyces coelicolor.. Cell Mol Life Sci
  2. Draft genomes, phylogenetic reconstruction and comparative genomics of two novel cohabiting bacterial symbionts isolated from Frankliniella occidentalis.. Genome Biology and Evolution
  3. Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of Med3 co-activator.. PNAS 111
  4. & Symbiont-mediated RNA interference in insects. Proceedings of the Royal Society B: Biological Sciences 283(1825), 20160042
  5. & Targeting the Osmotic Stress Response for Strain Improvement of an Industrial Producer of Secondary Metabolites. Journal of Microbiology and Biotechnology 25(11), 1787-1795.

See more...

Teaching

  • PM-120 Genetic Analysis I

    This module will give assignments designed to develop skills in essay writing and oral presentations. It will also look at the principles and practice of internet searching for scientific sources.

  • PM-200 Genetic Analysis II

    This module will give assignments designed to build on essay writing and oral presentation skills introduced in level 1. It will also develop critical evaluation, analysis skills for the understanding of peer-reviewed research papers.

  • PM-251 Microbial Molecular Genetics

    The control systems governing gene expression in prokaryotic cells are explored and the molecular basis for gene regulation introduced. Practical skills in obtaining and analysing data on a bacterial system are developed. The module then assesses the structure of the bacterial genome and how genetic analysis can be used to investigate structure and function of individual components of that genome. Specific examples explored in depth are the genetics of recombination and DNA repair. The technologies used for functional genomic analysis of fully sequenced bacteria are described with reference to analysis of human pathogens. Finally, the module includes examples of synthetic biology applied to bacteria.

  • PM-253 Techniques in Molecular Biology

    The module will provide a sound theoretical and practical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.

  • PM-253C Technegau Bioleg Foleciwlaidd

    Bydd y modiwl yn darparu sylfaen ddamcaniaethol ac ymarferol gref ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoir pwyslais penodol ar dechnoleg ailgyfuno DNA, dilyniannu cenhedlaeth nesaf, transgriptomeg, proteomeg a sbectrometreg màs.

  • PM-304 Biomolecular Research Project

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  • PM-315 Genetic Analysis III

    The module aims to develop the student¿s ability to critically analyse and synthesise advanced research topics in genetics and molecular biology, and their oral and written scientific presentation skills.

  • PM-336 Biomedical Laboratory Techniques

    The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.

  • PM-344 Capstone Project

    The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. Depending on the student's employability strand within the programme, the project may be laboratory, data, or education-based, but it will always involve a research question that is drawn from the literature, focused on a topic relevant to medical science. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.

  • PM-345 Bioinformatics: From sequence to Function

    The ever increasing availability of genome sequences and protein structure data demands that molecular biologists are proficient at performing extensive data analyses to guide and support traditional laboratory-based research. This Module will provide the theoretical basis and practical training on computational tools currently used to assemble and interrogate genome sequences, infer gene and protein functions, and to examine protein structure data.

Supervision

  • Population genomics of bacterial pathogens (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
  • Exploring the role of insect symbionts in host speciation: Lessons learned from the molecular characterisation of the microbiome in Psylloides and Ceutorhyncus species (current)

    Student name:
    MSc
    Other supervisor: Prof Paul Dyson
  • Population genomics approaches to understanding the evolution and ecology of bacterial pathogens (current)

    Student name:
    PhD
    Other supervisor: Dr Thomas Wilkinson
  • Study of the correlation between heavy metal content in polluted soils and antibiotic and heavy metal resistance and siderophore/antibiotics biosynthesis. (current)

    Student name:
    PhD
    Other supervisor: Dr Geertje Van Keulen
  • Molecular characterization of Frankliniella occidentails gut symbionts: Implications to the design of novel bio-pesticides (current)

    Student name:
    PhD
    Other supervisor: Prof Paul Dyson
  • Companion diagnostic development guides Antibody-Drug Conjugate formulation: Implications for patient stratification and precision medicine (current)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan