Dr Seo-Kyung Chung
Senior Lecturer
Swansea University Medical School
Telephone: (01792) 602421
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Dr Seo-Kyung Chung is a Senior Lecturer in the Swansea University Medical School (SUMS) where she has established a Molecular Neuroscience Research Team since 2005. She has extensive research experience in investigating cardiac and neurological disorders and worked in various institutions including UCL (UK), the Queensland Brain Institute (Australia) and the University of Auckland Centre for Brain Research (New Zealand).  She has gained her BSc (Hons) in Biomedical Science and DipSci (specialised in Bioinformatics) at the University of Auckland. Dr Chung was awarded a PhD in Neuroscience & Genetics in 2010 and recently a Postgraduate Certificate in Teaching in Higher Education (PGCHE) from Swansea University. She was a recipient of a prestigious Epilepsy Research UK Fellowship in 2011 and a winner of The Age UK Award for Outstanding Impact in Health and Wellbeing in 2015.

Dr Chung is the Swansea representative of the British Neuroscience Association (BNA) and a collaborator in the HCRW BRAIN Unit, Wales Gene Park and Welcome Trust Synaptopathy Programme at UCL. She is a Fellow of Higher Education Academic (FHEA) and a Member of the American Society of Human Genetics (ASHG) and the Society for Neuroscience (SFN).  She is interested in creating high-quality neuroscience & genetics programmes integrating current research into teaching.  Her research team offers well-established research / work experience programmes to undergraduate and postgraduate students. 

Please contact Dr Chung (s.chung@swansea.ac.uk) for further information about research projects available in her group.

Areas of Expertise

  • Neuroscience
  • Genetics
  • Bioinformatics
  • Molecular and cellular assays
  • Mutation analysis of neurological disorders
  • Next generation sequencing
  • Biobanking
  • Epilepsy
  • Hyperekplexia
  • Functional characterisation of mutations
  • Neurodevelomental disorders

Publications

  1. & Expanding the phenotype of TRAK1 mutations: hyperekplexia and refractory status epilepticus. Brain
  2. & Reply: ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation. Brain
  3. & A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy. Brain
  4. et. al. De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain
  5. Ultra-rare genetic variation in common epilepsies: a case-control sequencing study. The Lancet Neurology 16(2), 135-143.

See more...

Teaching

  • PM-226 Human and Medical Genetics

    The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.

  • PM-257 Neuroscience

    In order to help students understand the biological basis for behavioural neuroscience and neurological disorders, this module seeks to integrate the multidisciplinary sciences - for example, anatomy, physiology and biochemistry - that have combined to build the emerging field of neuroscience. The aim is to gain a mechanistic and holistic knowledge of the nervous system that builds from the molecular, cellular and developmental, to the systems level. In addition to exploring normal function, this module will introduce common disorders of the central and peripheral nervous systems in an integrated way. Students will be guided in exploring the scientific evidence around what is known and unknown and will be introduced to current research findings in the scientific literature.

  • PM-304 Biomolecular Research Project

    *

  • PMGM00 Bioinformatics for Genome Analysis

    The module will cover the fundamental principles of informatics and bioinformatics applied to clinical genomics, find and use major genomic and genetic data resources; use software packages, in silico tools, databases and literature searches to align sequence data to the reference genome, critically assess, annotate and interpret findings from genetic and genomic analyses. Theoretical sessions will be coupled with practical assignments of analysing and annotating predefined data sets.

  • PMGM16 Genomics of Common and Rare Inherited Disease

    This module will provide an introduction to the clinical presentation and manifestations of rare inherited and common diseases, and considers the patient and family perspective with respect to the role and impact of genomics. It reviews traditional and current strategies and techniques used to identify genes responsible for both common multifactorial and rare inherited diseases.

Supervision

  • Using Novel Data Types for Big Data Research in Epilepsy: Patient Records, Clinic Letters and Genetic Mutation (current)

    Student name:
    PhD
    Other supervisor: Dr Xianghua Xie
    Other supervisor: Prof Mark Rees
  • Analysis of potential mRNA splice-affecting gene-variants identified in epilepsy families and cases (current)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Mark Rees
  • Biobanking neurological conditions in Wales for Genetic Research (current)

    Student name:
    PhD
    Other supervisor: Dr Jonathan Mullins
    Other supervisor: Prof Mark Rees