About Me

Head of Systems Process Engineering Centre (SPEC)
Director, Centre for Nanohealth (Engineering)

Research interests include:
Graphene Biosensors
Sensors & Biosensors
Microfluidics
Microneedles & MEMS
Semiconductors
Silicon Nanowires
Silicon Carbide
Device Processing
Nanomedicine
Tissue Scaffolds
Photovoltaics

Prof. Owen J Guy (OJG), is Professor in nanotechnology at the College of Engineering in Swansea University, working in nanotechnology and advanced materials for healthcare applications. OJG is Director of the Centre for Nanohealth in the College of Engineering at Swansea University; a unique facility applying device fabrication & clean room semiconductor processing to healthcare problems in collaboration with industry. OJG is also head of the Systems Process & Engineering Centre (SPEC) one of 3 research centres within Swansea’s College of Engineering. OJG has PI grant income of more than £4 million. OJG has published over 50 journal papers, holds 2 granted patents (WO2011004136 and P100072GB), and was one of six candidates shortlisted for the Royal Academy of Engineering 2009 young entrepreneur award. OJG has founded 3 spin-out companies.

Areas of Expertise

  • Graphene
  • Biosensors
  • Silicon Nanowire Devices
  • MEMS
  • Microfluidics & Microneedles
  • Photovoltaics

Publications

  1. & Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker. 2D Materials 1(2), 025004
  2. & Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker. Biosensors and Bioelectronics 52, 216-224.
  3. & Epitaxial graphene immunosensor for human chorionic gonadotropin. Sensors and Actuators B: Chemical 190, 723-729.
  4. & Chitosan/AuNPs Modified Graphene Electrochemical Sensor for Label-Free Human Chorionic Gonadotropin Detection. Electroanalysis 26(12), 2591-2598.
  5. & Novel single-wall carbon nanotube screen-printed electrode as an immunosensor for human chorionic gonadotropin. Electrochimica Acta 136, 323-329.

See more...

Teaching

  • EGDM01 Colloid and Interface Science

    Students will gain an in-depth understanding of the properties of colloids and their importance in industry.

  • EGLM01 Wide Band-gap Electronics

    State-of-the-art materials and technology will be considered with emphasis on diamond silicon carbide & gallium nitride. The course will cover everything from materials growth through device processing technology, to devices and applications. Current commercial devices and anticipated devices will be highlighted and discussed.

  • EGNM02 Soft Nanotechnology

    This module introduces fundamental concepts in soft condensed matter physics/chemistry, and looks at the use of this knowledge in a wide range of 'soft matter'-based applications, including organic electronics, micro/nano-fluidics and molecular motors. A strong emphasis of the course is the fundamental physical processes that control the structure/behaviour of macromolecules.

  • EGNM07 Principles of Nanomedicine

    This module will cover the broad range of subjects which encompass the discipline nanomedicine. Building on the foundation of a knowledge of nanotechnology this module will focus on medical applications including biological markers, diagnostics, therapeutics and drug delivery vehicles.

  • PM-230 Selected Medical Diagnostic Techniques

    This module looks at the design and operation of a wide range of instrumentation used to make measurements for diagnostic and monitoring purposes. The emphasis is on the underlying electrical, mechanical, chemical, optical and other engineering principles.

  • PMND00 Nanomedicine Research Dissertation

    This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study within nanomedicine.

  • PMNM02 Diagnostics and Imaging

    Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

  • PMZM13 Diagnostics and Imaging

    Nanotechnology may lead to more rapid diagnostic tests, implantable devices, point of care instruments and improved medical imaging. This module will explore the application of nanotechnology to various medical techniques, focussing on novel research devices, pre-clinical tools and emerging technology within hospitals.

Supervision

  • Development of POC diagnostic sensors and integrated microfluidics (current)

    Student name:
    MPhil
    Other supervisor: Prof Huw Summers
  • Ethics, Governance and Emerging Nanotechnology (Provisional) (current)

    Student name:
    PhD
    Other supervisor: Prof Michael Mcnamee
  • Automated Bioreactors and Microcarriers for Therapeutical Cell Manufacturing (current)

    Student name:
    MSc
    Other supervisor: Dr Zhidao Xia
  • 'Lab on chip technology for biosensor diagnostics ' (current)

    Student name:
    MSc
    Other supervisor: Dr Marco Ellero
  • 'Development of PEO/CS nanofibers via needleless electrospinning for tissue engineering applications' (current)

    Student name:
    MSc
    Other supervisor: Dr Christopher Wright
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Rob Daniels
  • Membrane separation processes as a means of treating fracking wastewaters. (current)

    Student name:
    PhD
    Other supervisor: Dr Darren Oatley-Radcliffe
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Untitled (current)

    Student name:
    PhD
    Other supervisor: Prof Rhodri Williams
  • Graphene functionalisation and biosensor devices (current)

    Student name:
    PhD
    Other supervisor: Dr Rob Daniels
  • Development of innovative technologies in women health for the clinical diagnosis of female infertility and gynaecological cancer (current)

    Student name:
    PhD
    Other supervisor: Dr Deyarina Gonzalez
  • Lab on chip system for blood clotting analyses (current)

    Student name:
    PhD
    Other supervisor: Prof Huw Summers
  • Multiphysical modelling of micro and nanodevices (current)

    Student name:
    PhD
    Other supervisor: Dr Lijie Li
  • 'Application of self-assembling nano-peptide hydrogels for sustained delivery to enhance osteogenesis' (awarded 2016)

    Student name:
    MSc
    Other supervisor: Dr Zhidao Xia
  • 'Development of a silicon nanowire biosensor for detection of hormones related to stress' (awarded 2015)

    Student name:
    MSc
    Other supervisor: Prof Huw Summers
  • 'Characterisation of the surface reactions and gas sensing properties of zinc oxide nanosheets' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Mr Thierry Maffeis
  • 'Growth and functionalisation of Zinc Oxide Nanowires for Biosensing Applications' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Prof Steve Wilks
  • 'The optimisation of tissue regeneration for bone grafts' (awarded 2015)

    Student name:
    PhD
    Other supervisor: Dr Christopher Wright
  • 'Drug-loaded microspheres in conjunction with hydrogel patches for treatment of Psoriasis' (awarded 2015)

    Student name:
    MSc
    Other supervisor: Dr Zhidao Xia
  • 'Integrated biosensor and microfluidics point of care system' (awarded 2014)

    Student name:
    MSc
    Other supervisor: Dr Davide Deganello
  • 'Development of a Cortisol Biosensor' (awarded 2014)

    Student name:
    MSc
    Other supervisor: Dr Deyarina Gonzalez
  • 'Thin wafer based silicon solar cells' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Paul Rees
  • 'Epitaxial graphene growth and biosensor fabrication' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
  • 'Graphene and carbon nanotube biosensors for detection of human chorionic gondatropin' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Prof Steve Conlan
  • 'Integrated silicon nanowire biosensor and MEMS based delivery systems' (awarded 2014)

    Student name:
    PhD
    Other supervisor: Dr Rob Daniels
    Other supervisor: Dr Paolo Bertoncello
  • 'Functionalisation of semiconductor surface for biosensor application' (awarded 2012)

    Student name:
    PhD
    Other supervisor: Prof Shareen Doak
  • An investigation of epitaxial graphene growth and devices for biosensor applications (awarded 2012)

    Student name:
    PhD
    Other supervisor: Mr Thierry Maffeis
  • Development of microneedles for health applications (awarded 2012)

    Student name:
    MRes
    Other supervisor: Prof Huw Summers
  • Fabrication and Characterisation of Silicon Nanowire Devices and Sensors (awarded 2010)

    Student name:
    MRes
    Other supervisor: Prof Paul Rees
  • Silicon carbide power MOSFET technology (awarded 2010)

    Student name:
    PhD
    Other supervisor: Dr Petar Igic
  • Functionalisation of Semiconductor Surface (awarded 2008)

    Student name:
    MRes
    Other supervisor: Mr Thierry Maffeis

Key Grants and Projects

  • EPSRC EP/M006301/1 “Novel Point-of-Care Diagnostic Techniques for Dementia” 2014 - 2014

    , £1.2M

  • EPSRC (EP/L020734/1) “Manufacture of silicon microneedles for drug & vaccine delivery” 2014 - 2014

    , £800k

  • EPSRC (EP/L024799/1) “Healthcare Impact Partnership for new blood clotting diagnostics and management” 2014 - 2014

    , with PI Prof. P.R. Williams, £1.2M

  • TSB “Microneedles for delivery applications” 2014 - 2014

    , £0.5M

  • EPSRC (EP/G061882/1) “Grand Challenge in Nanomedicine” 2014 - 2014

    , with PI Prof. P.R. Williams, £1.8M

  • Welsh Government: “Swansea Nano ACCESS Knowledge Transfer Centre” 2013 - 2014

    , £850,000

  • EPSRC EP/I00193X/1, “ULTRA-SENSITIVE GRAPHENE NANO-BIOSENSORS” 2010 - 2012

    , £126,000

  • KTP “Development of nano structure growth processes utilising STS’ Liquid Delivery system (LDS)” 2010 - 2013

    , £182,000

  • NIHR “Development of Nitric Oxide Sensor” 2011 - 2014

    , with PI Prof. G Williams, £345,000

  • “Grid Parity Photovoltaics 2011 - 2014

    , £164,000

  • KESS “Conductive microneedles 2011 - 2011

    , £26,000

  • Welsh Government: “Semiconductor & Photonics Technology: Knowledge Transfer Centre” 2010 - 2013

    , £444,000

  • Welsh Government: Non invasive ambulatory and continuous monitoring of chronic diseases 2010 - 2014

    , with PI Dr. K.S. Teng, £265,000

  • H2020 Marie-Sklodowska-Curie Innovative Training Network: “Blood Biomarker-Based Diagnostic Tools for Early Stage Alzheimer's Disease (BBDiag)” 2016

    (in collaboration with Plymouth University)

  • Innovate UK – in collaboration with NPL, ProGnomics & U. Cambridge (Innovate UK) 2015

  • KTP (in collaboration with Perpetuus Ltd) 2015

  • NRN – “Graphene sensors for stroke marker detection” 2014

    (in collaboration with Cardiff University)

  • NRN - (in collaboration with Bangor) 2014

  • EPSRC – Platform Grant “Engineering Blood Diagnostics: Integrated Platforms for Advanced Detection and Analysis” 2014 - 2017

    , with Co-I, PI Prof Huw Summers

  • KTP (PI) (Innoture) – Drug delivery using polymer microneedles 2015

  • Technology Strategy Board - “Manufacturing Electronic Systems of the Future”. CRD “Integration of silicon and printed electronics for sensor applications”. 0

  • TSB grant TS/L001640/1 - “Precise therapy using minimally-invasive microneedle devices”. 10 - 2013

  • TSB: Interactive Research in Silicon Carbide – INTRINSiC 2005 - 2008

Research

Biosensors:
Prof. Guy’s group is developing Point of Care (POC) sensor technology based on graphene and silicon nanowire biosensors - for application in ultra-sensitive, non-invasive and early stage diagnostics. Such sensitivity enables biomarker detection in real clinical applications much more rapidly and for a greater variety of diagnostic applications than is currently possible using immunoassay or lateral flow tests.

OJG’s group has 14 years’ experience in clean room device fabrication (silicon, graphene & MEMS technology). OJG developed the world’s first epitaxial graphene biosensors in 2010 for detection of a cancer risk marker, through successful EPSRC project (EP/I00193X/1)[O. Guy et al., 2D Materials 1 (2014) 025004; Sensors and Actuators B: Chemical, 2014. 190(0): p. 723-729; J. Mater. Chem. B, 2014, doi: 10.1039/C3TB21235A, Patents (WO2011004136 A1) and (P100072GB)].

Microfluidics Technology:
OJG’s group is also pioneering integration of biosensor chips, based on active nanostructure transducers, with microfluidics EP/M006301/1. OJG has also developed silicon microneedle (MN) and microfluidics technology through EPSRC (EP/G061882/1, EP/L020734/1 & EP/I00193X/1, EP/N013506/1), KTP (KTP007901), & TSB / Innovate UK projects (101498). OJG has successfully supervised several PhD and MSc projects and has worked closely with a wide range of industry partners.