Professor Owen Guy

Professor Owen Guy

Owen Guy

 

Professor, College of Engineering

Overview

Specialist Subjects: Graphene, Biosensors, silicon nanowires, microneedles and microfluidics, MEMS & BioMEMS, Wide Band-Gap Semiconductors (Silicon Carbide), Device Processing

Working in the field of advanced materials for microelectronics and nanotechnology at College of Engineering, Swansea University

Multidisciplinary background: OJG specialises in the fabrication Graphene and silicon nanowire biosensors using semiconductor processing techniques and the integration of sensors with icrofluidics and device packaging technology. Other research areas include semiconductor materials – particularly silicon carbide and diamond and silicon photovoltaics.

Find out more

Research

Research interests include:

  • Graphene
  • Biosensors
  • Silicon Nanowires
  • Microfluidics, Microneedles & MEMS
  • Semiconductors & Device Processing, Nanoimprint Lithography
  • Photovoltaics (silicon based PV)
  • Tissue Scaffolds

Dr. Owen J Guy (OJG) is Associate Professor in nanotechnology at the College of Engineering in Swansea University, working in nanotechnology and advanced materials for healthcare applications.

Dr. Owen Guy’s group is developing POC sensor technology based on graphene and silicon nanowire biosensors - for application in ultra-sensitive, non-invasive and early stage diagnostics. Such sensitivity enables biomarker detection in real clinical applications much more quickly and for a greater variety of diagnostic applications than is currently possible using conventional ELISA or lateral flow tests.

Micro-system technologies: Our technology development programme seeks to utilise semiconductor processing technology and nano-fabrication techniques to manufacture miniaturised point of care (POC) sensor and microfluidic devices. This has included epitaxial graphene sensors for detection of a cancer risk marker, through a EPSRC project (EP/I00193X/1); development of microneedle technology through EPSRC (EP/G061882/1 & EP/L020734/1), KTP (KTP007901), & TSB (101498) projects.

We are also pioneering the integration of active biosensor chips with microfluidics and device packaging technology.

Other multi-disciplinary research includes nanotechnology, nano and microfabrication, electronic materials, devices & processing technology, surface science, photovoltaics and sensors, funded by EPSRC, TSB, (Technology Strategy Board), EU and the Welsh Government.

The group is based at Swansea’s new £21m Centre for Nanohealth (CNH); a new nano-device fabrication facility dedicated to providing nanotechnology solutions for healthcare.

Recent projects:

  • EPSRC EP/M006301/1 “Novel Point-of-Care Diagnostic Techniques for Dementia” - £1.2M (2014).
  • EPSRC (EP/L020734/1) “Manufacture of silicon microneedles for drug & vaccine delivery” - £800k (2014).
  • EPSRC (EP/L024799/1) “Healthcare Impact Partnership for new blood clotting diagnostics and management” - £1.2M (2014). (PI Prof. P.R. Williams).
  • TSB “Microneedles for delivery applications” - £0.5M (2014)
  • EPSRC (EP/G061882/1) “Grand Challenge in Nanomedicine” (2009-2012) - £1.8M. (2014). (PI Prof. P.R. Williams). 
  • Welsh Government: “Swansea Nano ACCESS Knowledge Transfer Centre” - £850,000. (2013-2014).
  • EPSRC EP/I00193X/1, “ULTRA-SENSITIVE GRAPHENE NANO-BIOSENSORS” -£126,000. (2010-2012). 
  • KTP “Development of nano structure growth processes utilising STS’ Liquid Delivery system (LDS)” - £182,000. (2010-2013)
  • NIHR “Development of Nitric Oxide Sensor” £345,000: (2011 – 2014) (PI Prof. G Williams)
  • “Grid Parity Photovoltaics” - £164,000. (2011-2014)
  • KESS “Conductive microneedles” -  £26,000. (2011)
  • Welsh Government: “Semiconductor & Photonics Technology: Knowledge Transfer Centre” - £444,000. (2010-2013)
  • Welsh Government: Non invasive ambulatory and continuous monitoring of chronic diseases - £265,000. (2010-2014). (PI Dr. K.S. Teng)

Selected publications

  • Z Tehrani, G Burwell, M A Mohd Azmi, A Castaing, R Rickman, J Almarashi, P Dunstan, A Miran Beigi, S H Doak, O J Guy, Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker, 2D Materials, 2014, 1, 2, [DOI: 10.1088/2053-1583/1/2/025004]
  • Matthew J. Webb, Craig Polley, Kai Dirscherl, Gregory Burwell, Palmgren, Yuran Niu, Anna Lundstedt, Alexei A. Zakharov, Owen J. Guy, Thiagarajan Balasubramanian, Rositsa Yakimova, Helena Grennberg, Effects of a modular two-step ozone-water and annealing process on silicon carbide graphene, Applied Physics Letters, 2014, 105, 8, [ISSN:0003-6951], [DOI: 10.1063/1.4893781]
  • Sofia Teixeira, Robert S. Conlan, O. J. Guy, M. Goreti F. Sales, Label-free human chorionic gonadotropin detection at picogram levels using oriented antibodies bound to graphene screen-printed electrodes, Journal of Materials Chemistry B, 2014, 2, 13, [ISSN:2050-750X], [DOI: 10.1039/C3TB21235A]
  • Sofia Teixeira, G. Burwell, A. Castaing, D. Gonzalez, R.S. Conlan, O.J. Guy, Epitaxial graphene immunosensor for human chorionic gonadotropin, Sensors and Actuators B: Chemical, 2014, 190, [ISSN:09254005], [DOI: 10.1016/j.snb.2013.09.019]
  • Sofia Teixeira, Robert Steven Conlan, O.J. Guy, M. Goreti F. Sales, Novel single-wall carbon nanotube screen-printed electrode as an immunosensor for human chorionic gonadotropin, Electrochimica Acta, 2014, 136, [ISSN:00134686], [DOI: 10.1016/j.electacta.2014.05.105]
  • M.A. Mohd Azmi, Z. Tehrani, R.P. Lewis, K.-A.D. Walker, D.R. Jones, D.R. Daniels, S.H. Doak, O.J. Guy, Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker, Biosensors and Bioelectronics, 2014, 52, [ISSN:09565663], [DOI: 10.1016/j.bios.2013.08.030]
  • Sofia Teixeira, Nadia S. Ferreira, Robert Steven Conlan, O. J. Guy, M. Goreti F. Sales, Chitosan/AuNPs Modified Graphene Electrochemical Sensor for Label-Free Human Chorionic Gonadotropin Detection, Electroanalysis, 2014, 26, 12, [ISSN:10400397], [DOI: 10.1002/elan.201400311]
  • Yufei Liu, Owen James Guy, Jash Patel, Huma Ashraf, Nick Knight, Refractive index graded anti-reflection coating for solar cells based on low cost reclaimed silicon, Microelectronic Engineering, 2013, 110, [ISSN:01679317], [DOI: 10.1016/j.mee.2013.03.003]
  • Yufei Liu, Huma Ashraf, Kerry Roberts, Nick Knight, Pay F. Eng, Owen J. Guy, Advanced deep reactive-ion etching technology for hollow microneedles for transdermal blood sampling and drug delivery, IET Nanobiotechnology, 2013, 7, 2, [ISSN:1751-8741], [DOI: 10.1049/iet-nbt.2012.0018]
  • Y Liu, A Servant, O.J Guy, Khuloud T Al-Jamal, P.R Williams, K.M Hawkins, K Kostarelos, An electric-field responsive microsystem for controllable miniaturised drug delivery applications, Sensors and Actuators B: Chemical, 2012, 175, [ISSN:09254005], [DOI: 10.1016/j.snb.2011.12.069]
  • Y. Liu, A. Servant, O.J. Guy, Khuloud T. Al-Jamal, P.R. Williams, K.M. Hawkins, K. Kostarelos, An electric-field responsive microsystem for controllable miniaturised drug delivery applications, Sensors and Actuators B: Chemical, 2012, 175, [ISSN:09254005], [DOI: 10.1016/j.snb.2011.12.069]
  • Owen J. Guy, Gregory Burwell, Zari Tehrani, Ambroise Castaing, Kelly Ann Walker, S.H. Doak, Graphene Nano-Biosensors for Detection of Cancer Risk, Materials Science Forum, 2012, 711, [DOI: 10.4028/www.scientific.net/MSF.711.246]
  • T.G.G. Maffeis, M.W. Penny, A. Castaing, O.J. Guy, S.P. Wilks, XPS investigation of vacuum annealed vertically aligned ultralong ZnO nanowires, Surface Science, 2012, 606, 1-2, [ISSN:00396028], [DOI: 10.1016/j.susc.2011.09.007]
  • P. M Gammon, A , M. R Jennings, O. J Guy, N Rimmer, J Llobet, N Mestres, P Godignon, M Placidi, M Zabala, J. A Covington, P. A Mawby, Integration of HfO[sub 2] on Si/SiC heterojunctions for the gate architecture of SiC power devices, Applied Physics Letters, 2010, 97, 1, [ISSN:00036951], [DOI: 10.1063/1.3462932]
  • P. F Eng, P Nithiarasu, O. J Guy, An experimental study on an electro-osmotic flow-based silicon heat spreader, Microfluidics and Nanofluidics, 2010, 9, 4-5, [ISSN:1613-4990], [DOI: 10.1007/s10404-010-0594-3]
  • Owen J Guy, Ambroise Castaing, Zari Tehrani, S H Doak, Fabrication of ultrasensitive graphene nanobiosensors, 2010, [DOI: 10.1109/ICSENS.2010.5690883]
  • P. M. Gammon, A. , M. R. Jennings, O. J. Guy, N. Rimmer, J. Llobet, N. Mestres, P. Godignon, M. Placidi, M. Zabala, J. A. Covington, P. A. Mawby, Integration of HfO[sub 2] on Si/SiC heterojunctions for the gate architecture of SiC power devices, Applied Physics Letters, 2010, 97, 1, [ISSN:00036951], [DOI: 10.1063/1.3462932]
  • Michael R. Jennings, Amador , Owen J. Guy, Michal Lodzinski, Peter M. Gammon, Susan Burrows, James A. Covington, Philip A. Mawby, Silicon-on-SiC, a Novel Semiconductor Structure for Power Devices, Materials Science Forum, 2010, 645-648, [DOI: 10.4028/www.scientific.net/MSF.645-648.1243]
  • A , M Lodzinski, O. J Guy, M. R Jennings, M Placidi, J Llobet, P. M Gammon, M. C Davis, J. A Covington, S. E Burrows, P. A Mawby, Si/SiC bonded wafer: A route to carbon free SiO[sub 2] on SiC, Applied Physics Letters, 2009, 94, 10, [ISSN:00036951], [DOI: 10.1063/1.3099018]
  • A. , M. Lodzinski, O. J. Guy, M. R. Jennings, M. Placidi, J. Llobet, P. M. Gammon, M. C. Davis, J. A. Covington, S. E. Burrows, P. A. Mawby, Si/SiC bonded wafer: A route to carbon free SiO[sub 2] on SiC, Applied Physics Letters, 2009, 94, 10, [ISSN:00036951], [DOI: 10.1063/1.3099018]
  • A. , M. Lodzinski, O. J. Guy, M. R. Jennings, M. Placidi, J. Llobet, P. M. Gammon, M. C. Davis, J. A. Covington, S. E. Burrows, P. A. Mawby, Si/SiC bonded wafer: A route to carbon free SiO[sub 2] on SiC, Applied Physics Letters, 2009, 94, 10, [ISSN:00036951], [DOI: 10.1063/1.3099018]
  • A. Castaing, O.J. Guy, M. Lodzinski, S.P. Wilks, Investigation of Graphene Growth on 4H-SiC, Materials Science Forum, 2009, 615-617, [DOI: 10.4028/www.scientific.net/MSF.615-617.223]
  • M. Lodzinski, O.J. Guy, A. Castaing, S. Batcup, S.P. Wilks, P. Igic, R.S. Balmer, C.J.H. Wort, R. Lang, Metal Contacts to Boron-Doped Diamond, Materials Science Forum, 2009, 615-617, [DOI: 10.4028/www.scientific.net/MSF.615-617.995]
  • O.J. Guy, Amador , M.R. Jennings, M. Lodzinski, A. Castaing, P.A. Mawby, J.A. Covington, S.P. Wilks, R. Hammond, D. Connolly, S. Jones, J. Hopkins, T. Wilby, N. Rimmer, K. Baker, S. Conway, S. Evans, Investigation of Si/4H-SiC Hetero-Junction Growth and Electrical Properties, Materials Science Forum, 2009, 615-617, [DOI: 10.4028/www.scientific.net/MSF.615-617.443]
  • D. Doneddu, O.J. Guy, P.R. Dunstan, T.G.G. Maffeis, K.S. Teng, S.P. Wilks, P. Igic, D. Twitchen, R.M. Clement, X-ray photoelectron spectroscopy studies on the formation of chromium contacts to single-crystal CVD diamond, Surface Science, 2008, 602, 6, [ISSN:00396028], [DOI: 10.1016/j.susc.2007.12.021]
  • O.J Guy, D Doneddu, L Chen, M.R Jennings, M.P Ackland, R Baylis, M.D Holton, P Dunstan, S.P Wilks, P.A Mawby, Improved Schottky contacts to annealed 4H-SiC using a protective carbon cap: Investigated using current voltage measurements and atomic force microscopy, 2006, pp.1472-1477, [ISBN:0925-9635], [DOI: 10.1016/j.diamond.2005.11.010]
  • John O Morley, Owen J Guy, Michael H Charlton, Mechanistic studies on the photodegradation of azoarenes, 2005, pp.174-184, [ISBN:1010-6030], [DOI: 10.1016/j.jphotochem.2005.02.001]
  • John O Morley, Owen J Guy, Michael H Charlton, Molecular Modeling Studies on the Photochemical Stability of Azo Dyes, 2004, pp.10542-10550, [ISBN:1089-5639], [DOI: 10.1021/jp047001o]
  • O.J Guy, G Pope, I Blackwood, K.S Teng, L Chen, W.Y Lee, S.P Wilks, P.A Mawby, Creating room temperature Ohmic contacts to 4H-SiC: studied by specific contact resistance measurements and X-ray photoelectron spectroscopy, 2004, pp.253-263, [ISBN:0039-6028], [DOI: 10.1016/j.susc.2004.09.035]
  • Owen Guy, Handbook of Light Emitting and Schottky Diode Research, 0

Teaching

  • EGNM02 - Soft Nanotechnology (15/16)
  • PM-230 - Selected Medical Diagnostic Techniques (15/16)
  • EGLM01 - Wide Band-gap Electronics (15/16)
  • EGDM01 - Colloid and Interface Science (15/16)
  • PMNM02 - Diagnostics and Imaging (15/16)
  • PMND00 - Nanomedicine Research Dissertation (15/16)
  • PMZM13 - Diagnostics and Imaging (15/16)

Research theses supervised

PhD

  • 2015 - To be defined (2nd Supervisor: Dr Deyarina Gonzalez)
  • 2015 - Lab on chip system for blood clotting analyses (2nd Supervisor: Professor Huw Summers)
  • 2015 - Development of innovative technologies in women health for the clinical diagnosis of female infertility and gynaecological cancer (1st Supervisor: Dr Deyarina Gonzalez)
  • 2015 - Multiphysical modelling of micro and nanodevices (1st Supervisor: Dr Lijie Li)
  • 2014 - Graphene functionalisation and biosensor devices (2nd Supervisor: Dr David Daniels)
  • 2014 - Membrane separation processes as a means of treating fracking wastewaters. (2nd Supervisor: Dr Darren Oatley-Radcliffe)
  • 2014 - Ethics, Governance and Emerging Nanotechnology (Provisional) (1st Supervisor: Professor Michael Mcnamee)
  • 2011 - 'Characterisation of the surface reactions and gas sensing properties of zinc oxide nanosheets' (1st Supervisor: Mr Thierry Maffeis)
  • 2011 - 'Integrated silicon nanowire biosensor and MEMS based delivery systems' (2nd Supervisor: Dr David Daniels)
  • 2011 - 'Graphene and carbon nanotube biosensors for detection of human chorionic gondatropin' (2nd Supervisor: Professor Robert Conlan)
  • 2010 - 'The optimisation of tissue regeneration for bone grafts' (2nd Supervisor: Dr Christopher Wright)
  • 2010 - 'Growth and functionalisation of Zinc Oxide Nanowires for Biosensing Applications' (1st Supervisor: Professor Stephen Wilks)
  • 2010 - 'Epitaxial graphene growth and biosensor fabrication' (2nd Supervisor: Professor Shareen Doak)
  • 2010 - 'Thin wafer based silicon solar cells' (2nd Supervisor: Professor Paul Rees)
  • 2008 - 'Functionalisation of semiconductor surface for biosensor application' (2nd Supervisor: Professor Shareen Doak)
  • 2007 - An investigation of epitaxial graphene growth and devices for biosensor applications (2nd Supervisor: Mr Thierry Maffeis)
  • 2006 - Silicon carbide power MOSFET technology (1st Supervisor: Dr Petar Igic)

MPhil

  • 2015 - Development of POC diagnostic sensors and integrated microfluidics (2nd Supervisor: Professor Huw Summers)

MRes

  • 2010 - Development of microneedles for health applications (2nd Supervisor: Professor Huw Summers)
  • 2009 - Fabrication and Characterisation of Silicon Nanowire Devices and Sensors (2nd Supervisor: Professor Paul Rees)
  • 2007 - Functionalisation of Semiconductor Surface (2nd Supervisor: Mr Thierry Maffeis)

MSc

  • 2015 - To be defined (2nd Supervisor: Dr Deyarina Gonzalez)
  • 2015 - Lab on chip technology for biosensor diagnostics (2nd Supervisor: Dr Marco Ellero)
  • 2015 - Development of innovative technologies in women health for the clinical diagnosis of female infertility and gynaecological cancer (1st Supervisor: Dr Deyarina Gonzalez)
  • 2015 - Automated Bioreactors and Microcarriers for Therapeutical Cell Manufacturing (1st Supervisor: Dr Zhidao Xia)
  • 2015 - Development of POC diagnostic sensors and integrated microfluidics (2nd Supervisor: Professor Huw Summers)
  • 2014 - 'Process optimisation for metal contacts to a silicon nanowire biosensor device'
  • 2014 - Preparation of thin film silver nanoparticles for nanocatalysis
  • 2013 - 'Development of a silicon nanowire biosensor for detection of hormones related to stress' (2nd Supervisor: Professor Huw Summers)
  • 2013 - 'Application of self-assembling nano-peptide hydrogels for sustained delivery to enhance osteogenesis' (1st Supervisor: Dr Zhidao Xia)
  • 2013 - 'Development of PEO/CS nanofibers via needleless electrospinning for tissue engineering applications' (1st Supervisor: Dr Christopher Wright)
  • 2013 - 'Graphene''''s Potential as a base for biosensor applications'
  • 2013 - 'Development of electronic reader technology for PoC health diagnostic devices'
  • 2013 - 'Development of sensor and flow cell technology for biosensing applications'
  • 2013 - 'Drug-loaded microspheres in conjunction with hydrogel patches for treatment of Psoriasis' (1st Supervisor: Dr Zhidao Xia)
  • 2012 - 'Development of a Cortisol Biosensor' (2nd Supervisor: Dr Deyarina Gonzalez)
  • 2012 - 'Development of Si NW biosensors for hormone detection'
  • 2012 - 'Integrated biosensor and microfluidics point of care system' (2nd Supervisor: Dr Davide Deganello)
  • 2009 - To be defined