Baby Riley is world-first for Swansea doctor
First newborn in the world to receive xenon gas in a bid to prevent brain injury
St Michael’s Hospital, part of University Hospitals Bristol NHS Foundation Trust, has become the first hospital in the world to successfully deliver xenon gas to a newborn baby in a bid to prevent brain injury following a lack of oxygen at birth.
This pioneering technique has been developed by Marianne Thoresen, Professor of Neonatal Neuroscience at the University of Bristol and Dr John Dingley, consultant anaesthetist and Reader in Anaesthetics at Swansea University’s School of Medicine. This study is being funded by Sparks, the children’s medical research charity.
In the UK, every year, more than 1,000 otherwise healthy babies born at full term die or suffer brain injury caused by a lack of oxygen and/or blood supply at birth. This can lead to lifelong problems such as cerebral palsy.
St Michael’s Hospital and the University of Bristol has pioneered new treatments for brain injury in babies since Marianne Thoresen first started cooling babies in 1998, showing that cooling babies after a lack of oxygen could reduce damage in the newborn brain. After her original laboratory work from 1995 showing that cooling after lack of oxygen reduced brain injury in animal models, clinical trials of cooling have now proven that mild cooling by only a few degrees for 72 hours is a safe and beneficial treatment. However, cooling only partially reduces disability and does not prevent it in all babies. The search has been to find a second treatment that could be added to cooling to further reduce disability.
Professor Marianne Thoresen, says: “Xenon is a very rare and chemically inert anaesthetic gas found in tiny quantities in the air that we breathe. In 2002 John Dingley and I realised the potential xenon and cooling might have in combination to further reduce disability. Over the past eight years, we have shown in the laboratory that xenon doubles the protective effect of cooling on the brain; however we faced the challenge of how to safely and effectively deliver this rare and extremely expensive gas to newborn babies.”
Dr Dingley has been developing equipment in Swansea for xenon anaesthesia in adults for over 10 years and has invented a machine to successfully deliver the gas to babies. His machine takes the exhaled gas, removes any waste products from it and re-circulates it to be breathed again without any loss at all to the outside air. Some types of specialist military diving equipment work in this way but it is very unusual to build a system small enough to work reliably in newborn babies.
Dr Dingley, says: “A key design feature of this machine is that it is very efficient, using less than 200ml of xenon per hour – less than the volume of a soft drinks can. Xenon is a precious and finite resource and difficult to extract so it can cost up to £30 per litre. As ventilated newborns breathe many litres of air per minute, any xenon based treatment would be impossibly expensive without an economical delivery method.”
He continued: “Despite these challenges, the lack of side-effects and brain protecting properties of xenon make it uniquely attractive as a potential treatment to apply alongside cooling in these babies. We are very grateful to Sparks, the children’s medical research charity, for supporting us in making this happen.”
Following rigorous Medicines and Healthcare Regulatory Authority approvals and other regulatory challenges, the device is now authorised for clinical trials and will be used on a minimum of 12 babies over the coming months. Successful completion of this feasibility trial is the first required step before larger trials on the effectiveness of the treatment can be done in baby units on a larger scale.Many of the parts for Dr Dingley’s machine are specially built for the purpose by companies within Wales while other items are sourced from as far away as St. Petersburg in Russia.
‘The engineering heritage within South Wales has meant that I have been spoiled for choice whenever I have needed anything unusual constructed,’ Dr Dingley said,
‘Many local companies and individuals have helped me over the years, particularly PDR in Cardiff and I&G Engineering near Swansea. I designed equipment suitable for adults several years ago, however the challenges of developing a new design that works reliably and safely in babies is much greater. I have had to apply all the experience I have gained since 2000 to achieve this.
Professor Thoresen and Dr Dingley’s previously successful research work into cooling and the increased survival chances offered by xenon have been funded through the children’s medical research charity Sparks, which has committed almost £800,000 to the team’s pioneering work. The charity has, over recent years, committed almost £1.5m to cooling research, including the ‘CoolCap’ now being widely used in the NHS. Professor Thoresen was also heavily involved in the pioneering ‘CoolCap’ work.
The charity’s president, England World Cup winning hero, Sir Geoff Hurst, MBE, recently visited the Bristol project and yesterday commented:
‘Congratulations to Professor Thoresen, Dr Dingley and the rest of their dedicated team on this fantastic success. Breakthroughs such as this world-first graphically underscore the important role a charity like Sparks plays in funding pioneering research that really does make a difference. To me, a result like this is even more important than scoring the winning goal in a world cup final. I’m delighted that baby Riley hasn’t just survived a life or death situation, but can now look forward to a healthy future. That makes every penny Sparks has committed to this research work so worthwhile.’
For more information please contact:
Swansea University
Sian Newman – ILS Communications Manager on 01792 602362 or at s.y.newman@swansea.ac.uk. Alternatively, contact Bethan Evans, Swansea University Press Office on +44 (0)1792 295050 or at b.w.evans@swansea.ac.uk.
Monday 29th March 2010
Partners 4 Life Science Brokerage Event, 12th May 2010 at the ILS
The ILS in conjunction with MediWales are hosting a structured networking event to bring together industry, academics and the NHS to encourage greater collaboration. To book your place, register on the dedicated website: www.partners4lifescience.co.uk. For more information, contact Sian Newman
Confederation for British Industry (CBI) film features the ILS
The UK's CBI is producing a film on British innovation success stories, entitled 'A Quest for Success'. It will be distributed to over 30,000 CBI members during May 2010. The ILS, together with the Prince of Wales Innovation Scholarships, features in an eight minute section. To get a sneak preview, click here. You'll need to 'open' or 'save' the link in order to view.
Equipment arrives at the ILS as part of the Centre for NanoHealth project
As part of the Centre for NanoHealth project, the School of Medicine has recently been one of the first in the UK to have an IN Cell Analyzer 2000 from GE Healthcare installed. The IN Cell Analyzer 2000 is an automated, high-throughput cellular and molecular imaging system for high speed, multi-wavelength analysis of both live and fixed cells. It is amenable to a range of high-resolution fluorescence and bright-field test systems, capable of supporting multi-disciplinary applications from fixed end-point assays to extended live-cell studies where individual cells can be tracked. Its impressive capacity for image capture and analysis is therefore a very exciting prospect. For further information contact Dr Shareen Doak.
Also as part of the Centre for NanoHealth project an Amnis ImageStream imaging flow cytometer has been installed in the flow cytometry facility on the 2nd floor of the ILS building. The ImageStream imaging flow cytometer combines the visual power of microscopy with the speed and sensitivity of flow cytometry by digitally imaging cells directly in flow. Many biological phenomena can be studied using the brightness and location of fluorescence on, in, and between cells - even within rare sub-populations. Examples of applications include nuclear translocation, phagocytosis, shape change, spot counting, cell cycle and mitosis, and DNA damage and repair. For further information contact Dr Cathy Thornton.
Wales E-Health Industries Networking Event in High Demand
The one-day roundtable E-Health Wales Business-to-Business (B2B) Networking Event held last Tuesday 23 March at the Health Informatics Research Laboratories in Swansea University has received excellent feedback from delegates. Over twenty Welsh E-Health Small to Medium Enterprises (SMEs) attended the event following the success of E-Health Wales Industries Workshop in autumn 2009, commenting that the B2B networking event was very beneficial to their companies. All of the Welsh SMEs attended the networking event have made new useful business contacts and generated potential business/research collaborations with the E-Health Industries Innovation (EHi2) Centre led by David Ford. Once again, the organising team thank all EHi2’s Welsh SME Network members who have made this event a continued success and for their positive feedbacks:
“Surprisingly useful in generating synergy/alliance ideas.” - Hytec Limited, OLM Group
“The event had very good attendees with lots of interest - looking forward to liaison with some of these companies.” - CAL2CAL Europe
“I didn’t expect to make so many useful contacts in this networking event - 6 companies out of 11 companies presented - I consider it a very good ratio! I will continue to explore business opportunities with these companies after this event.” - Ocuco Limited
“Thought the spirit within the meeting was just what was needed - Many Congratulations - the facilitation was spot on. The meeting was very good and it was clear that most of those that attended felt they got a lot out of it. I thoroughly enjoyed it.” - Peak Performance
For more information, visit the event website or contact Stephanie Lee.